Transitional cell carcinoma classification

Transitional cell carcinoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

In the United States, bladder cancers usually start from the cells lining the bladder (called transitional cells).

These tumors are classified based on the way they grow:

• Papillary tumors have a wart-like appearance and are attached to a stalk.
• Nonpapillary (sessile) tumors are much less common. However, they are more invasive and have a worse outcome.

• Infiltrating urothelial carcinoma

• with squamous differentiation
• with glandular differentiation
• with trophoblastic differentiation
• Nested
• Microcystic
• Micropapillary
• Lymphoepithelioma-like
• Lymphoma-like
• Plasmacytoid
• Sarcomatoid
• Giant cell
• Undifferentiated

• Non-invasive urothelial neoplasias

• Urothelial carcinoma in situ
• Non-invasive papillary urothelial carcinoma, high grade
• Non-invasive papillary urothelial carcinoma, low grade
• Non-invasive papillary urothelial neoplasm of low
• Malignant potential
• Urothelial papilloma
• Inverted urothelial papilloma