Diphyllobothriasis medical therapy: Difference between revisions
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===Mechanism of action=== | ===Mechanism of action=== | ||
#Praziquantel | #[[Praziquantel]] | ||
#*Oral [[praziquantel]] is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state. | #*Oral [[praziquantel]] is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state. | ||
#Niclosamide | #[[Niclosamide]] | ||
#*[[Niclosamide]] inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites. | #*[[Niclosamide]] inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites. | ||
Revision as of 16:33, 14 July 2017
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Diphyllobothriasis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Diphyllobothriasis medical therapy On the Web |
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American Roentgen Ray Society Images of Diphyllobothriasis medical therapy |
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Risk calculators and risk factors for Diphyllobothriasis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Furqan M M. M.B.B.S[3]
Overview
Drugs used for diphyllobothriasis include either praziquantel or niclosamide.
Medical Therapy
The medications used in the treatment of diphyllobothriasis are:
Antimicrobial Regimen
Shown below is a table summarizing the preferred and alternative empiric treatment for Diphyllobothriasis[1]
| Pathogens | Preferred Treatment | Duration of Treatment | Alternative Treatment |
| Diphyllobothrium latum | Praziquantel*
Adults, 5-10 mg/kg orally in a single-dose therapy; the dosage for children is the same. |
Single dose | Niclosamide
Adult 2 gm orally once; children, 50 mg/kg (max 2 gm) orally once. |
Mechanism of action
- Praziquantel
- Oral praziquantel is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
- Niclosamide
- Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.