Diphyllobothriasis medical therapy: Difference between revisions
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The preferred and alternative empiric treatment for [[diphyllobothriasis]] is as follows: | The preferred and alternative empiric treatment for [[diphyllobothriasis]] is as follows: | ||
Preferred Regimen:[[Praziquantel]] 5-10 mg/kg orally in a single-dose therapy; for adults and children. | Preferred Regimen: [[Praziquantel]] 5-10 mg/kg orally in a single-dose therapy; for adults and children. | ||
Alternative Regimen:[[Niclosamide]] 2 gm single dose orally for adults; children, 50 mg/kg (max 2 gm) orally once. | Alternative Regimen: [[Niclosamide]] 2 gm single dose orally for adults; children, 50 mg/kg (max 2 gm) orally once. | ||
===Mechanism of action=== | ===Mechanism of action=== | ||
Revision as of 14:41, 25 July 2017
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Diphyllobothriasis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Diphyllobothriasis medical therapy On the Web |
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American Roentgen Ray Society Images of Diphyllobothriasis medical therapy |
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Risk calculators and risk factors for Diphyllobothriasis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2], Furqan M M. M.B.B.S[3]
Overview
Drugs used for diphyllobothriasis include either praziquantel or niclosamide.
Medical Therapy
The medications used in the treatment of diphyllobothriasis are:
Antimicrobial Regimen
The preferred and alternative empiric treatment for diphyllobothriasis is as follows:
Preferred Regimen: Praziquantel 5-10 mg/kg orally in a single-dose therapy; for adults and children.
Alternative Regimen: Niclosamide 2 gm single dose orally for adults; children, 50 mg/kg (max 2 gm) orally once.
Mechanism of action
- Praziquantel
- Oral praziquantel is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
- Niclosamide
- Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.