Syndrome of inappropriate antidiuretic hormone causes: Difference between revisions
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==Overview== | ==Overview== | ||
SIADH is caused by excess of [[renal]] water reabsorption through inappropriate [[antidiuretic hormone]] secretion | [[SIADH|Syndrome of inappropriate antidiuretic hormone]] is caused by excess of [[renal]] water reabsorption through inappropriate [[antidiuretic hormone]] secretion. There are various causes attributed to [[SIADH]] ranging from [[malignancies]], [[medications]], [[central nervous system]] causes, and [[infectious]]. Some of the most common causes of [[SIADH]] include malignancies, like [[small cell lung cancer]] and [[medications]], such as [[Selective serotonin reuptake inhibitor|selective serotonin reuptake inhibitors]] and [[Carbamazepine|carbamazepine]]. | ||
== | ==Causes== | ||
===Common causes=== | ===Common causes=== | ||
Head injury | * [[Head injury]] | ||
* [[Subarachnoid hemorrhage]] | * [[Subarachnoid hemorrhage]] | ||
* [[ | * [[Cancers]] | ||
** [[Lung cancer]] (especially [[Small cell lung cancer|small cell lung cance]] | ** [[Lung cancer]] (especially [[Small cell lung cancer|small cell lung cance]], as well as other small-cell malignancies of other organs) | ||
* [[ | * [[Infections]] | ||
** [[Brain | ** [[Brain abscess]] | ||
** [[Pneumonia]] | ** [[Pneumonia]] | ||
** [[Lung abscess]] | ** [[Lung abscess]] | ||
* [[ | * [[Medications]] | ||
** [[Chlorpropamide]] | ** [[Chlorpropamide]] | ||
** [[Cyclophosphamide]] | ** [[Cyclophosphamide]] | ||
** [[Carbamazepine]] | ** [[Carbamazepine]] | ||
** [[Selective serotonin reuptake | ** [[Selective serotonin reuptake inhibitors]] | ||
** [[Methylenedioxymethamphetamine]] (MDMA, commonly called Ecstasy) <ref name="pmid22029026">{{cite journal |vauthors=Pillai BP, Unnikrishnan AG, Pavithran PV |title=Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder |journal=Indian J Endocrinol Metab |volume=15 Suppl 3 |issue= |pages=S208–15 |year=2011 |pmid=22029026 |pmc=3183532 |doi=10.4103/2230-8210.84870 |url=}}</ref><ref name="pmid16738014">{{cite journal |vauthors=Schrier RW |title=Body water homeostasis: clinical disorders of urinary dilution and concentration |journal=J. Am. Soc. Nephrol. |volume=17 |issue=7 |pages=1820–32 |year=2006 |pmid=16738014 |doi=10.1681/ASN.2006030240 |url=}}</ref><ref name="pmid5570319">{{cite journal |vauthors=Derubertis FR, Michelis MF, Bloom ME, Mintz DH, Field JB, Davis BB |title=Impaired water excretion in myxedema |journal=Am. J. Med. |volume=51 |issue=1 |pages=41–53 |year=1971 |pmid=5570319 |doi= |url=}}</ref> | ** [[Methylenedioxymethamphetamine]] (MDMA, commonly called [[Ecstasy]])<ref name="pmid22029026">{{cite journal |vauthors=Pillai BP, Unnikrishnan AG, Pavithran PV |title=Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder |journal=Indian J Endocrinol Metab |volume=15 Suppl 3 |issue= |pages=S208–15 |year=2011 |pmid=22029026 |pmc=3183532 |doi=10.4103/2230-8210.84870 |url=}}</ref><ref name="pmid16738014">{{cite journal |vauthors=Schrier RW |title=Body water homeostasis: clinical disorders of urinary dilution and concentration |journal=J. Am. Soc. Nephrol. |volume=17 |issue=7 |pages=1820–32 |year=2006 |pmid=16738014 |doi=10.1681/ASN.2006030240 |url=}}</ref><ref name="pmid5570319">{{cite journal |vauthors=Derubertis FR, Michelis MF, Bloom ME, Mintz DH, Field JB, Davis BB |title=Impaired water excretion in myxedema |journal=Am. J. Med. |volume=51 |issue=1 |pages=41–53 |year=1971 |pmid=5570319 |doi= |url=}}</ref> | ||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
|'''Drugs''' | |'''Drugs''' | ||
|bgcolor="Beige"|[[Cyclophosphamide]], [[Desmopressin]], [[Mono amine oxidase inhibitors]], [[Nicotine]], [[Oxytocin]], [[Pergolide]], [[Phenothiazines]], [[SSRI]]s, [[Tricyclic antidepressant|Tricyclic antidepressants]],[[Monoamine oxidase inhibitors]], [[Vasopressin]], [[Vinblastine]], [[Vincristine]], [[Bromocriptine]], [[Clofibrate]], [[Prostaglandins]], [[Melphalan]], [[Interferon-alpha]], [[Tacrolimus]], [[Diclofenac]], [[Ibuprofen]], [[Fentanyl]], [[Amiodarone]], [[Hydrochlorothiazide|Hydrochlorthiazide]], [[Clonidine]], [[Levodopa]], [[Rituximab]], [[Methylenedioxymethamphetamine]], Leveteiracetam, Quinolones | |bgcolor="Beige"|[[Cyclophosphamide]], [[Desmopressin]], [[Mono amine oxidase inhibitors]], [[Nicotine]], [[Oxytocin]], [[Pergolide]], [[Phenothiazines]], [[SSRI]]s, [[Tricyclic antidepressant|Tricyclic antidepressants]],[[Monoamine oxidase inhibitors]], [[Vasopressin]], [[Vinblastine]], [[Vincristine]], [[Bromocriptine]], [[Clofibrate]], [[Prostaglandins]], [[Melphalan]], [[Interferon-alpha]], [[Tacrolimus]], [[Diclofenac]], [[Ibuprofen]], [[Fentanyl]], [[Amiodarone]], [[Hydrochlorothiazide|Hydrochlorthiazide]], [[Clonidine]], [[Levodopa]], [[Rituximab]], [[Methylenedioxymethamphetamine]], Leveteiracetam, [[Quinolones]] | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
| bgcolor="Beige" | [[Carcinoid]], [[Duodenal | | bgcolor="Beige" | [[Carcinoid]], [[Duodenal]] [[carcinoma]], [[Pancreatic cancer]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Infectious Disease''' | | '''Infectious Disease''' | ||
| bgcolor="Beige" | [[AIDS]], | | bgcolor="Beige" | [[AIDS]], [[Bacterial pneumonia]], [[Brain abscess]], [[Encephalitis]], [[Lung abscess]], [[Lung cavitation]], [[Meningitis]], [[Tuberculosis]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Neurologic''' | | '''Neurologic''' | ||
| bgcolor="Beige" | [[Agenesis corpus collosum]], [[Amyotropic lateral sclerosis]], [[Brain abscess]], [[Carcinoid]], [[Cavernous sinus thrombosis]], [[Delirium tremens]], [[Encephalitis]], [[Hydrocephalus]], [[Meningitis]], [[Multiple sclerosis]], [[Peripheral neuropathy]], [[Polyradiculitis]], [[Stroke]], [[Subarachnoid hemorrhage]], [[ Subdural hemorrhage]], [[Guillain-Barre Syndrome | | bgcolor="Beige" | [[Agenesis corpus collosum]], [[Amyotropic lateral sclerosis]], [[Brain abscess]], [[Carcinoid]], [[Cavernous sinus thrombosis]], [[Delirium tremens]], [[Encephalitis]], [[Hydrocephalus]], [[Meningitis]], [[Multiple sclerosis]], [[Peripheral neuropathy]], [[Polyradiculitis]], [[Stroke]], [[Subarachnoid hemorrhage]], [[Subdural hemorrhage]], [[Guillain-Barre Syndrome]], [[Traumatic brain injury]] | ||
|- | |- | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
| bgcolor="Beige" | [[Asthma]], | | bgcolor="Beige" | [[Asthma]], [[Bacterial pneumonia]], [[Bronchial adenoma]], [[Carcinoid]], [[Lung abscess]], [[Lung carcinoma]], Lung [[cavitation]], [[Mesothelioma]], [[Pneumothorax]], [[Tuberculosis]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
| bgcolor="Beige" | Positive pressure ventilation, Transsphenoidal surgery , [[Poly-arteritis nodosa]] | | bgcolor="Beige" | [[Positive pressure ventilation]], Transsphenoidal surgery , [[Poly-arteritis nodosa]] | ||
|} | |} | ||
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*[[Amyotropic lateral sclerosis]] | *[[Amyotropic lateral sclerosis]] | ||
*[[Asthma]] | *[[Asthma]] | ||
* | *[[Bacterial pneumonia]] | ||
*[[Brain abscess]] | *[[Brain abscess]] | ||
*[[Bronchial adenoma]] | *[[Bronchial adenoma]] | ||
| Line 157: | Line 157: | ||
*[[Delirium tremens]] | *[[Delirium tremens]] | ||
*[[Desmopressin]] | *[[Desmopressin]] | ||
*Duodenal [[carcinoma]] | *[[Duodenal]] [[carcinoma]] | ||
*[[Encephalitis]] | *[[Encephalitis]] | ||
*[[Ewing's sarcoma]] | *[[Ewing's sarcoma]] | ||
| Line 163: | Line 163: | ||
*[[Lung abscess]] | *[[Lung abscess]] | ||
*[[Lung carcinoma]] | *[[Lung carcinoma]] | ||
*Lung cavitation | *Lung [[cavitation]] | ||
*[[Meningitis]] | *[[Meningitis]] | ||
*[[Mesothelioma]] | *[[Mesothelioma]] | ||
| Line 178: | Line 178: | ||
*[[Pneumothorax]] | *[[Pneumothorax]] | ||
*[[Polyradiculitis]] | *[[Polyradiculitis]] | ||
*Positive pressure | *[[Positive pressure ventilation]] | ||
*[[Psychosis]] | *[[Psychosis]] | ||
*[[SSRI]] | *[[SSRI]] | ||
Revision as of 16:04, 11 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
Syndrome of inappropriate antidiuretic hormone is caused by excess of renal water reabsorption through inappropriate antidiuretic hormone secretion. There are various causes attributed to SIADH ranging from malignancies, medications, central nervous system causes, and infectious. Some of the most common causes of SIADH include malignancies, like small cell lung cancer and medications, such as selective serotonin reuptake inhibitors and carbamazepine.
Causes
Common causes
- Head injury
- Subarachnoid hemorrhage
- Cancers
- Lung cancer (especially small cell lung cance, as well as other small-cell malignancies of other organs)
- Infections
- Medications
Causes by Organ System
Causes in Alphabetical Order
- Agenesis corpus collosum
- AIDS
- Amyotropic lateral sclerosis
- Asthma
- Bacterial pneumonia
- Brain abscess
- Bronchial adenoma
- Carbamazepine
- Carcinoid
- Cavernous sinus thrombosis
- Chlorpropamide
- Cyclophosphamide
- Delirium tremens
- Desmopressin
- Duodenal carcinoma
- Encephalitis
- Ewing's sarcoma
- Hydrocephalus
- Lung abscess
- Lung carcinoma
- Lung cavitation
- Meningitis
- Mesothelioma
- Midline defects
- Mono Amine Oxidase Inhibitors
- Multiple sclerosis
- Nicotine
- Ovarian cancer
- Oxytocine
- Pancreatic cancer
- Pergolide
- Peripheral neuropathy
- Phenothiazines
- Pneumothorax
- Polyradiculitis
- Positive pressure ventilation
- Psychosis
- SSRI
- Stroke
- Thymoma
- Tricyclic antidepressants
- Tuberculosis
- Vasopressin
- Vinblastine
- Vincristine
References
- ↑ Pillai BP, Unnikrishnan AG, Pavithran PV (2011). "Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder". Indian J Endocrinol Metab. 15 Suppl 3: S208–15. doi:10.4103/2230-8210.84870. PMC 3183532. PMID 22029026.
- ↑ Schrier RW (2006). "Body water homeostasis: clinical disorders of urinary dilution and concentration". J. Am. Soc. Nephrol. 17 (7): 1820–32. doi:10.1681/ASN.2006030240. PMID 16738014.
- ↑ Derubertis FR, Michelis MF, Bloom ME, Mintz DH, Field JB, Davis BB (1971). "Impaired water excretion in myxedema". Am. J. Med. 51 (1): 41–53. PMID 5570319.