Angiopoietin receptor: Difference between revisions
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{{Infobox protein family | |||
| Symbol = TIE | |||
| Name = Angiopoietin receptor | |||
| image = | |||
| width = | |||
| caption = | |||
| Pfam= PF10430 | |||
| InterPro= IPR018941 | |||
| SMART= | |||
| Prosite = | |||
| SCOP = | |||
| TCDB = | |||
| OPM family= | |||
| OPM protein= | |||
| PDB= | |||
| Membranome family = 1214 | |||
}} | |||
{{protein | {{protein | ||
|Name=[[TIE1|tyrosine kinase with immunoglobulin-like and EGF-like domains 1]] | |Name=[[TIE1|tyrosine kinase with immunoglobulin-like and EGF-like domains 1]] | ||
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==Angiopoietins== | ==Angiopoietins== | ||
The [[angiopoietins]] are [[protein]] [[growth factors]] that | The [[angiopoietins]] are [[protein]] [[growth factors]] that regulate [[angiogenesis]], the formation of blood vessels. In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4)<ref>{{cite journal | vauthors = Jeltsch M, Leppanen VM, Saharinen P, Alitalo K | title = Receptor Tyrosine Kinase-Mediated Angiogenesis | journal = Cold Spring Harbor Perspectives in Biology | volume = 5 | issue = 9 | pages = a009183–a009183 | date = 2013 | pmid = 24003209 | pmc = 3753715 | doi = 10.1101/cshperspect.a009183 }}</ref>. Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor [[tyrosine kinases]], so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating [[cell signalling]]. | ||
Ang1, Ang2, | |||
It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.{{cn|date=February 2017}} | It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.{{cn|date=February 2017}} | ||
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==External links== | ==External links== | ||
* {{MeshName|TIE+Receptor+Tyrosine+Kinases}} | * {{MeshName|TIE+Receptor+Tyrosine+Kinases}} | ||
==References== | |||
{{reflist}} | |||
Revision as of 22:14, 13 August 2018
| Angiopoietin receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TIE | ||||||||
| Pfam | PF10430 | ||||||||
| InterPro | IPR018941 | ||||||||
| Membranome | 1214 | ||||||||
| |||||||||
| tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |
|---|---|
| Identifiers | |
| Symbol | TIE1 |
| Alt. symbols | TIE, JTK14 |
| Entrez | 7075 |
| HUGO | 11809 |
| OMIM | 600222 |
| RefSeq | NM_005424 |
| UniProt | P35590 |
| Other data | |
| EC number | 2.7.1.112 |
| Locus | Chr. 1 p34-p33 |
| TEK tyrosine kinase, endothelial | |
|---|---|
| Identifiers | |
| Symbol | TEK |
| Alt. symbols | TIE2, TIE-2, VMCM1, CD202b |
| Entrez | 7010 |
| HUGO | 11724 |
| OMIM | 600221 |
| RefSeq | NM_000459 |
| UniProt | Q02763 |
| Other data | |
| Locus | Chr. 9 p21 |
The angiopoietin receptors are receptors that bind angiopoietin.
TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).
Angiopoietins
The angiopoietins are protein growth factors that regulate angiogenesis, the formation of blood vessels. In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4)[1]. Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling.
It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation needed]
See also
External links
- TIE+Receptor+Tyrosine+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ↑ Jeltsch M, Leppanen VM, Saharinen P, Alitalo K (2013). "Receptor Tyrosine Kinase-Mediated Angiogenesis". Cold Spring Harbor Perspectives in Biology. 5 (9): a009183–a009183. doi:10.1101/cshperspect.a009183. PMC 3753715. PMID 24003209.
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