The [[adiponectin receptor]]s, [[AdipoR1]] and AdipoR2, serve as receptors for globular and full-length [[adiponectin]] and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/> Interestingly, in 2016, the University of Tokyo announced it was launching an investigation into anonymously made claims of fabricated and falsified data on the identification of AdipoR1 and AdipoR2.<ref name="Dennis">[http://www.sciencemag.org/news/2016/09/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups] ScienceInsider, Dennis Normile, Sep 20, 2016</ref>
The [[adiponectin receptor]]s, [[AdipoR1]] and AdipoR2, serve as receptors for globular and full-length [[adiponectin]] and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/> In 2016, the University of Tokyo announced it was launching an investigation into anonymously made claims of fabricated and falsified data on the identification of AdipoR1 and AdipoR2.<ref name="Dennis">[http://www.sciencemag.org/news/2016/09/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups] ScienceInsider, Dennis Normile, Sep 20, 2016</ref>
Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2gene.[1] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[2]
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1] In 2016, the University of Tokyo announced it was launching an investigation into anonymously made claims of fabricated and falsified data on the identification of AdipoR1 and AdipoR2.[3]
↑ 1.01.11.2Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. doi:10.1038/nature01705. PMID12802337.
↑Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID16044242.
↑Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. doi:10.1038/nature12656. PMID24172895.
