Peutz-Jeghers syndrome medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, [[radiotherapy]] or [[chemotherapy]] may be considered. | There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated [[cancer]], [[radiotherapy]] or [[chemotherapy]] may be considered. | ||
==Medical Therapy== | ==Medical Therapy== | ||
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*'''Intra-operative [[enteroscopy]]''' | *'''Intra-operative [[enteroscopy]]''' | ||
**[[Laparotomy]] ([[Laparoscopic surgery|laparoscopy]]) with [[endoscopy]] is done. | **[[Laparotomy]] ([[Laparoscopic surgery|laparoscopy]]) with [[endoscopy]] is done. | ||
**Best modality for diagnostic and therapeutic procedure of the small bowel. | **Best modality for diagnostic and therapeutic procedure of the small [[bowel]]. | ||
*'''Double balloon [[enteroscopy]]''' | *'''Double balloon [[enteroscopy]]''' | ||
**Allows examination and treatment of the | **Allows examination and treatment of the jejenum and ileum. | ||
* '''[[Chemoprophylaxis]]''' | * '''[[Chemoprophylaxis]]''' | ||
Latest revision as of 15:02, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, radiotherapy or chemotherapy may be considered.
Medical Therapy
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, radiotherapy or chemotherapy may be considered.
Patients with Peutz-Jeghers syndrome are treated with intra-operative enteroscopy (IOE) and double balloon enteroscopy (DBE).[1]
- Intra-operative enteroscopy
- Laparotomy (laparoscopy) with endoscopy is done.
- Best modality for diagnostic and therapeutic procedure of the small bowel.
- Double balloon enteroscopy
- Allows examination and treatment of the jejenum and ileum.
- Chemoprophylaxis
- Proven efficacy of rapamycin for Peutz-Jeghers syndrome in a mouse model.
References
- ↑ Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). "Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach". World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.