Atopic dermatitis natural history, complications and prognosis: Difference between revisions

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===Complications===
===Complications===
*Common complications of atopic dermatitis include:
*Common complications of atopic dermatitis include:
**Superinfection
**Super-infection
***Staphyloccus ''aureus''
***Staphylococcus ''aureus''<ref name="pmid21070347">{{cite journal |vauthors=Matiz C, Tom WL, Eichenfield LF, Pong A, Friedlander SF |title=Children with atopic dermatitis appear less likely to be infected with community acquired methicillin-resistant Staphylococcus aureus: the San Diego experience |journal=Pediatr Dermatol |volume=28 |issue=1 |pages=6–11 |date=2011 |pmid=21070347 |doi=10.1111/j.1525-1470.2010.01293.x |url=}}</ref>
***herpes simplex virus  
***Herpes simplex virus ( Kaposi varicelliform eruption or eczema herpeticum) - occurs in <3% of patients
***Molluscum contagiosum 
**Sleep problems due to intense pruritus
**Ocular comorbidities
***Atopic keratoconjunctivitis<ref name="pmid24342754">{{cite journal |vauthors=Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC |title=Atopic keratoconjunctivitis: A review |journal=J. Am. Acad. Dermatol. |volume=70 |issue=3 |pages=569–75 |date=March 2014 |pmid=24342754 |doi=10.1016/j.jaad.2013.10.036 |url=}}</ref>
***Vernal keratoconjunctivitis<ref name="pmid25744396">{{cite journal |vauthors=Pattnaik L, Acharya L |title=A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics |journal=Life Sci. |volume=128 |issue= |pages=47–54 |date=May 2015 |pmid=25744396 |doi=10.1016/j.lfs.2015.01.040 |url=}}</ref>
***keratoconus
***Infectious keratitis
***blepharitis
** Topical corticosteroids can leasd to striae
** Atopy march: other atopic disorders such as allergic rhinitis food allergy and asthma
***
***
**
**
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**
**
===Prognosis===
===Prognosis===
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
*Atopic dermatitis is chronic disease with varying subtypes.<ref name="pmid15131576">{{cite journal |vauthors=Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U |title=The natural course of atopic dermatitis from birth to age 7 years and the association with asthma |journal=J. Allergy Clin. Immunol. |volume=113 |issue=5 |pages=925–31 |date=May 2004 |pmid=15131576 |doi=10.1016/j.jaci.2004.01.778 |url=}}</ref>
*Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
*The presence of severe atopic dermatitis and early atopic sensitization is associated with a particularly poor prognosis.<ref name="pmid151315762">{{cite journal |vauthors=Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U |title=The natural course of atopic dermatitis from birth to age 7 years and the association with asthma |journal=J. Allergy Clin. Immunol. |volume=113 |issue=5 |pages=925–31 |date=May 2004 |pmid=15131576 |doi=10.1016/j.jaci.2004.01.778 |url=}}</ref>
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
*Mortality is unusual in atopic dermatitis.
*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
[[Category: (name of the system)]]
[[Category: (name of the system)]]
==Complications==
* Infections of the [[skin]] caused by [[bacteria]], [[fungi]], or [[virus]]es
* Permanent scars
* Side effects from long-term use of medicines to control [[eczema]]
==Prognosis==
Atopic dermatitis is a long-term condition. You can control it with treatment, by avoiding irritants, and by keeping the skin well-moisturized.
In children, the condition often starts to go away around age 5 - 6, but flare-ups will often occur. In adults, the problem is generally a long-term or returning condition.
Atopic dermatitis may be harder to control if it:
* Begins at an early age
* Involves a large amount of the body
* Occurs along with [[allergic rhinitis]] and [[asthma]]
* Occurs in someone with a family history of [[eczema]]
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 14:47, 9 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of atopic dermatitis usually starts during the first years of life, and presents with symptoms such as intense pruritus and chronic and relapsing age dependent eczematous lesions.[1]
  • Majority of the infants and children with atopic dermatitis, usually grow out of the disease during childhood.[2]
  • In severe cases, atopic dermatitis continue or relapses in adulthood.[3]
  • Natural history of atopic dermatitis can be categorized into various subtypes according to the clinical features.
    • The most common subtype was characterized by the early onset of atopic dermatitis (<2 years) and persistent until adulthood.[4]
  • In the sequence of atopy march diseases, atopic dermatits is the first to commence during infancy, followed by allergic rhinits, food allergy and asthma later in life.[5]
  • Atopic dermatitis is a life long disease with periods of waxing and waning eczematous skin lesions.[6]

Complications

  • Common complications of atopic dermatitis include:
    • Super-infection
      • Staphylococcus aureus[7]
      • Herpes simplex virus ( Kaposi varicelliform eruption or eczema herpeticum) - occurs in <3% of patients
      • Molluscum contagiosum
    • Sleep problems due to intense pruritus
    • Ocular comorbidities
      • Atopic keratoconjunctivitis[8]
      • Vernal keratoconjunctivitis[9]
      • keratoconus
      • Infectious keratitis
      • blepharitis
    • Topical corticosteroids can leasd to striae
    • Atopy march: other atopic disorders such as allergic rhinitis food allergy and asthma

Prognosis

  • Atopic dermatitis is chronic disease with varying subtypes.[10]
  • The presence of severe atopic dermatitis and early atopic sensitization is associated with a particularly poor prognosis.[11]
  • Mortality is unusual in atopic dermatitis.

References

  1. ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
  2. ↑ Burr ML, Dunstan FD, Hand S, Ingram JR, Jones KP (June 2013). "The natural history of eczema from birth to adult life: a cohort study". Br. J. Dermatol. 168 (6): 1339–42. doi:10.1111/bjd.12216. PMID 23301666.
  3. ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
  4. ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
  5. ↑ Spergel JM (August 2010). "From atopic dermatitis to asthma: the atopic march". Ann. Allergy Asthma Immunol. 105 (2): 99–106, quiz 107–9, 117. doi:10.1016/j.anai.2009.10.002. PMID 20674819.
  6. ↑ Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ (June 2014). "Persistence of mild to moderate atopic dermatitis". JAMA Dermatol. 150 (6): 593–600. doi:10.1001/jamadermatol.2013.10271. PMC 4352328. PMID 24696036.
  7. ↑ Matiz C, Tom WL, Eichenfield LF, Pong A, Friedlander SF (2011). "Children with atopic dermatitis appear less likely to be infected with community acquired methicillin-resistant Staphylococcus aureus: the San Diego experience". Pediatr Dermatol. 28 (1): 6–11. doi:10.1111/j.1525-1470.2010.01293.x. PMID 21070347.
  8. ↑ Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC (March 2014). "Atopic keratoconjunctivitis: A review". J. Am. Acad. Dermatol. 70 (3): 569–75. doi:10.1016/j.jaad.2013.10.036. PMID 24342754.
  9. ↑ Pattnaik L, Acharya L (May 2015). "A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics". Life Sci. 128: 47–54. doi:10.1016/j.lfs.2015.01.040. PMID 25744396.
  10. ↑ Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U (May 2004). "The natural course of atopic dermatitis from birth to age 7 years and the association with asthma". J. Allergy Clin. Immunol. 113 (5): 925–31. doi:10.1016/j.jaci.2004.01.778. PMID 15131576.
  11. ↑ Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U (May 2004). "The natural course of atopic dermatitis from birth to age 7 years and the association with asthma". J. Allergy Clin. Immunol. 113 (5): 925–31. doi:10.1016/j.jaci.2004.01.778. PMID 15131576.


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