Atopic dermatitis laboratory findings: Difference between revisions
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* The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum IgE level, which is not present in about 20% of affected individuals.<ref name="pmid23473856">{{cite journal |vauthors=Kabashima K |title=New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity |journal=J. Dermatol. Sci. |volume=70 |issue=1 |pages=3–11 |date=April 2013 |pmid=23473856 |doi=10.1016/j.jdermsci.2013.02.001 |url=}}</ref> | * The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum IgE level, which is not present in about 20% of affected individuals.<ref name="pmid23473856">{{cite journal |vauthors=Kabashima K |title=New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity |journal=J. Dermatol. Sci. |volume=70 |issue=1 |pages=3–11 |date=April 2013 |pmid=23473856 |doi=10.1016/j.jdermsci.2013.02.001 |url=}}</ref> | ||
* Monitoring of IgE levels is not recommended for the assessment of atopic dermatitis severity. | * Monitoring of IgE levels is not recommended for the assessment of atopic dermatitis severity. | ||
* Some of new biomarkers using the SCORing Atopic Dermatitis (SCORAD) index and other severity scales | * Some of new biomarkers using the SCORing Atopic Dermatitis (SCORAD) index and other severity scales<ref name="pmid17047294">{{cite journal |vauthors=Aral M, Arican O, Gul M, Sasmaz S, Kocturk SA, Kastal U, Ekerbicer HC |title=The relationship between serum levels of total IgE, IL-18, IL-12, IFN-gamma and disease severity in children with atopic dermatitis |journal=Mediators Inflamm. |volume=2006 |issue=4 |pages=73098 |date=2006 |pmid=17047294 |pmc=1618943 |doi=10.1155/MI/2006/73098 |url=}}</ref> | ||
** | ** Serum levels of CD30 | ||
** Macrophage-derived chemoattractant (MDC) | |||
** Interleukins (IL)-12 | |||
** Interleukins (IL)-16 | |||
** Interleukins (IL)-18 | |||
** Interleukins (IL)-31 | |||
** Thymus and activation-regulated chemokine (TARC) | |||
*** | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 16:43, 11 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There diagnosis of atopic dermatitis remains clinical as there is no reliable bio-marker that can differentiate the atopic dermatitis from other skin diseases.
Laboratory Findings
- There are no reliable diagnostic laboratory findings associated with atopic dermatitis.
- The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum IgE level, which is not present in about 20% of affected individuals.[1]
- Monitoring of IgE levels is not recommended for the assessment of atopic dermatitis severity.
- Some of new biomarkers using the SCORing Atopic Dermatitis (SCORAD) index and other severity scales[2]
- Serum levels of CD30
- Macrophage-derived chemoattractant (MDC)
- Interleukins (IL)-12
- Interleukins (IL)-16
- Interleukins (IL)-18
- Interleukins (IL)-31
- Thymus and activation-regulated chemokine (TARC)
References
- ↑ Kabashima K (April 2013). "New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity". J. Dermatol. Sci. 70 (1): 3–11. doi:10.1016/j.jdermsci.2013.02.001. PMID 23473856.
- ↑ Aral M, Arican O, Gul M, Sasmaz S, Kocturk SA, Kastal U, Ekerbicer HC (2006). "The relationship between serum levels of total IgE, IL-18, IL-12, IFN-gamma and disease severity in children with atopic dermatitis". Mediators Inflamm. 2006 (4): 73098. doi:10.1155/MI/2006/73098. PMC 1618943. PMID 17047294.