Atopic dermatitis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There is no established system for the classification of atopic dermatitis.

Atopic dermatitis may be classified according to means of allergic sensitization into:

• Intrinsic atopic dermatitis
• Extrinsic atopic dermatitis

Intrinsic AD	Extrinsic AD
Normal serum IgE levels No specific IgE sensitization against Environmental allergens Food allergens Skin prick tests No filaggrin mutation Relative lower levels of IL-4 and IL-13 Increased eosinophil counts and eosinophil cationic protein levels	Elevated total serum IgE levels IgE sensitization against Environmental allergens Food allergens Skin prick tests Filaggrin mutations may be present Increased levels of IL-4, IL-5 and IL-13 Increased eosinophil counts and eosinophil cationic protein levels

OR

[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].

OR

[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].

OR

Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.

OR

If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].

OR

The staging of [malignancy name] is based on the [staging system].

OR

There is no established system for the staging of [malignancy name].

Classification

There is no established system for the classification of atopic dermatitis.

Atopic dermatitis may be classified according to means of allergic sensitization into:

• Intrinsic atopic dermatitis
• Extrinsic atopic dermatitis

Intrinsic AD	Extrinsic AD
Normal serum IgE levels No specific IgE sensitization against Environmental allergens Food allergens Skin prick tests No filaggrin mutation Relative lower levels of IL-4 and IL-13 Increased eosinophil counts and eosinophil cationic protein levels	Elevated total serum IgE levels IgE sensitization against Environmental allergens Food allergens Skin prick tests Filaggrin mutations may be present Increased levels of IL-4, IL-5 and IL-13 Increased eosinophil counts and eosinophil cationic protein levels