Spina bifida laboratory findings: Difference between revisions
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*An elevated concentration of Maternal Serum [[Alpha-fetoprotein|Alpha-Fetoprotein]] may be predictive for contemporary detection of spina bifida.<ref name="pmid26332586">{{cite journal |vauthors=Racusin DA, Villarreal S, Antony KM, Harris RA, Mastrobattista J, Lee W, Shamshirsaz AA, Belfort M, Aagaard KM |title=Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida |journal=Am J Perinatol |volume=32 |issue=14 |pages=1287–91 |date=December 2015 |pmid=26332586 |doi=10.1055/s-0035-1562930 |url=}}</ref> | *An elevated concentration of Maternal Serum [[Alpha-fetoprotein|Alpha-Fetoprotein]] may be predictive for contemporary detection of spina bifida.<ref name="pmid26332586">{{cite journal |vauthors=Racusin DA, Villarreal S, Antony KM, Harris RA, Mastrobattista J, Lee W, Shamshirsaz AA, Belfort M, Aagaard KM |title=Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida |journal=Am J Perinatol |volume=32 |issue=14 |pages=1287–91 |date=December 2015 |pmid=26332586 |doi=10.1055/s-0035-1562930 |url=}}</ref> | ||
* Screening for spina bifida by mother's blood's [[Alpha-fetoprotein|AFP]] [alpha‐fetoprotein] is recommended for all pregnant women with Triple Test.<ref name="pmid4381295">{{cite journal |vauthors=Péron FG, McCarthy JL, Guerra F |title=Further studies on corticosteroidogenesis. IV. Inhibition of utilization of biological substrates for corticoid synthesis by high calcium concentrations. Possible role of transhydrogenase in corticosteroidogenesis |journal=Biochim. Biophys. Acta |volume=117 |issue=2 |pages=450–69 |date=April 1966 |pmid=4381295 |doi= |url=}}</ref><ref name="pmid1071059">{{cite journal |vauthors=Wyshak G, Haase JV |title=Profile of dental hygienists |journal=Dent Hyg (Chic) |volume=50 |issue=11 |pages=497–501 |date=November 1976 |pmid=1071059 |doi= |url=}}</ref> | * Screening for spina bifida by mother's blood's [[Alpha-fetoprotein|AFP]] [alpha‐fetoprotein] is recommended for all pregnant women with Triple Test.<ref name="pmid4381295">{{cite journal |vauthors=Péron FG, McCarthy JL, Guerra F |title=Further studies on corticosteroidogenesis. IV. Inhibition of utilization of biological substrates for corticoid synthesis by high calcium concentrations. Possible role of transhydrogenase in corticosteroidogenesis |journal=Biochim. Biophys. Acta |volume=117 |issue=2 |pages=450–69 |date=April 1966 |pmid=4381295 |doi= |url=}}</ref><ref name="pmid1071059">{{cite journal |vauthors=Wyshak G, Haase JV |title=Profile of dental hygienists |journal=Dent Hyg (Chic) |volume=50 |issue=11 |pages=497–501 |date=November 1976 |pmid=1071059 |doi= |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
There are no specific laboratory findings in the newborn associated with spina bifida. An elevated concentration of Maternal Serum Alpha-Fetoprotein may be predictive for contemporary detection of spina bifida. Screening for spina bifida by mother's blood's AFP [alpha‐fetoprotein] is recommended for all pregnant women with Triple Test. Triple test looks for three specific substances: AFP, hCG, and Estriol. Triple test is performed between the 15th and 20th week of pregnancy preferably in the 16th -18th week.
Laboratory Findings
- There are no specific laboratory findings associated with spina bifida.
- An elevated concentration of Maternal Serum Alpha-Fetoprotein may be predictive for contemporary detection of spina bifida.[1]
- Screening for spina bifida by mother's blood's AFP [alpha‐fetoprotein] is recommended for all pregnant women with Triple Test.[2][3]
- Triple test looks for three specific substances: AFP, hCG, and Estriol.[2][4]
- Triple test is performed between the 15th and 20th week of pregnancy preferably in the 16th -18th week.[2][4][3][5]
- All pregnant women should have triple test dureng pregnancy, but is is more important in pregnants with:[2][4]
- In patients with high level of AFP, use of ultrasound and amniocentesis may be useful to diagnose open neural tube defects including spina bifida.[4][3][5]
References
- ↑ Racusin DA, Villarreal S, Antony KM, Harris RA, Mastrobattista J, Lee W, Shamshirsaz AA, Belfort M, Aagaard KM (December 2015). "Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida". Am J Perinatol. 32 (14): 1287–91. doi:10.1055/s-0035-1562930. PMID 26332586.
- ↑ 2.0 2.1 2.2 2.3 Péron FG, McCarthy JL, Guerra F (April 1966). "Further studies on corticosteroidogenesis. IV. Inhibition of utilization of biological substrates for corticoid synthesis by high calcium concentrations. Possible role of transhydrogenase in corticosteroidogenesis". Biochim. Biophys. Acta. 117 (2): 450–69. PMID 4381295.
- ↑ 3.0 3.1 3.2 Wyshak G, Haase JV (November 1976). "Profile of dental hygienists". Dent Hyg (Chic). 50 (11): 497–501. PMID 1071059.
- ↑ 4.0 4.1 4.2 4.3 Hu Z, Liu X, Li L, Jia C, Li D, Liu R (October 2014). "[Predictive value of abnormal second-trimester maternal serum triple screening markers for adverse pregnancy outcomes]". Zhonghua Fu Chan Ke Za Zhi (in Chinese). 49 (10): 749–53. PMID 25537246.
- ↑ 5.0 5.1 Shcherbukhin VV, Khramtsov AV, Zemskov VM, Filatov AV (April 1987). "[Poisson equalization of multicomponent cytofluorograms]". Tsitologiia (in Russian). 29 (4): 497–502. PMID 3111043.