Autoimmune retinopathy causes: Difference between revisions
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==Overview== | ==Overview== | ||
As with all autoimmune diseases, autoimmune retinopathy is caused by antibodies cross reacting against the retinal, and retinal like antigens. <ref name="pmid32823399" /> | |||
Main antibodies against retinal proteins associated with AIR include, anti-recoverin, anti-alpha-enolase, anti-transducin, anti-CAII, anti-arrestin, anti-rhodopsin, anti-Muller glial cells, anti-mitofilin, anti-tintin, anti-COX. However, seronegative disease is also common. | |||
==Causes== | ==Causes== | ||
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As with all autoimmune diseases, autoimmune retinopathy is caused by antibodies cross reacting against the retinal, and retinal like antigens. <ref name="pmid32823399">{{cite journal| author=Dutta Majumder P, Marchese A, Pichi F, Garg I, Agarwal A| title=An update on autoimmune retinopathy. | journal=Indian J Ophthalmol | year= 2020 | volume= 68 | issue= 9 | pages= 1829-1837 | pmid=32823399 | doi=10.4103/ijo.IJO_786_20 | pmc=7690499 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32823399 }} </ref> | As with all autoimmune diseases, autoimmune retinopathy is caused by antibodies cross reacting against the retinal, and retinal like antigens. <ref name="pmid32823399">{{cite journal| author=Dutta Majumder P, Marchese A, Pichi F, Garg I, Agarwal A| title=An update on autoimmune retinopathy. | journal=Indian J Ophthalmol | year= 2020 | volume= 68 | issue= 9 | pages= 1829-1837 | pmid=32823399 | doi=10.4103/ijo.IJO_786_20 | pmc=7690499 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32823399 }} </ref> | ||
Main antibodies against retinal proteins associated with AIR include | Main antibodies against retinal proteins associated with AIR include, anti-recoverin, anti-alpha-enolase, anti-transducin, anti-CAII, anti-arrestin, anti-rhodopsin, anti-Muller glial cells, anti-mitofilin, anti-tintin, anti-COX. However, seronegative disease is also common. | ||
Anti-recoverin is associated with rapid onset and visual decline as compared to anti-alpha-enolase. <ref name="pmid29340169">{{cite journal| author=Canamary AM, Takahashi WY, Sallum JMF| title=Autoimmune retinopathy: A Review. | journal=Int J Retina Vitreous | year= 2018 | volume= 4 | issue= | pages= 1 | pmid=29340169 | doi=10.1186/s40942-017-0104-9 | pmc=5759752 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340169 }} </ref> | Anti-recoverin is associated with rapid onset and visual decline as compared to anti-alpha-enolase. <ref name="pmid29340169">{{cite journal| author=Canamary AM, Takahashi WY, Sallum JMF| title=Autoimmune retinopathy: A Review. | journal=Int J Retina Vitreous | year= 2018 | volume= 4 | issue= | pages= 1 | pmid=29340169 | doi=10.1186/s40942-017-0104-9 | pmc=5759752 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340169 }} </ref> | ||
Revision as of 16:23, 17 July 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
As with all autoimmune diseases, autoimmune retinopathy is caused by antibodies cross reacting against the retinal, and retinal like antigens. [1]
Main antibodies against retinal proteins associated with AIR include, anti-recoverin, anti-alpha-enolase, anti-transducin, anti-CAII, anti-arrestin, anti-rhodopsin, anti-Muller glial cells, anti-mitofilin, anti-tintin, anti-COX. However, seronegative disease is also common.
Causes
As with all autoimmune diseases, autoimmune retinopathy is caused by antibodies cross reacting against the retinal, and retinal like antigens. [1]
Main antibodies against retinal proteins associated with AIR include, anti-recoverin, anti-alpha-enolase, anti-transducin, anti-CAII, anti-arrestin, anti-rhodopsin, anti-Muller glial cells, anti-mitofilin, anti-tintin, anti-COX. However, seronegative disease is also common.
Anti-recoverin is associated with rapid onset and visual decline as compared to anti-alpha-enolase. [2]
| Type of Autoimmune retinopathy | Antibody specificity |
|---|---|
| Cancer-associated retinopathy (CAR) | Anti-recoverin, Anti-alpha-enolase, Anti-transducin, Anti-carbonic anhydrase II |
| Melanoma-associated retinopathy (MAR) | Anti-transducin, Anti-carbonic anhydrase II, Anti-arrestin, Anti-rhodopsin, Anti-Muller glial cells,
Anti-mitofilin (mitochondrial protein), Anti-tintin, Anti-COX (cytochrome c oxidase, assembly mitochondrial protein) |
| Non-paraneoplastic AIR (npAIR) | Anti-alpha-enolase, Anti-transducin, Anti-carbonic anhydrase II |
References
- ↑ 1.0 1.1 Dutta Majumder P, Marchese A, Pichi F, Garg I, Agarwal A (2020). "An update on autoimmune retinopathy". Indian J Ophthalmol. 68 (9): 1829–1837. doi:10.4103/ijo.IJO_786_20. PMC 7690499 Check
|pmc=value (help). PMID 32823399 Check|pmid=value (help). - ↑ Canamary AM, Takahashi WY, Sallum JMF (2018). "Autoimmune retinopathy: A Review". Int J Retina Vitreous. 4: 1. doi:10.1186/s40942-017-0104-9. PMC 5759752. PMID 29340169.