Leg swelling

Leg swelling

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Leg swelling may involve one both legs, and can occur with general edema

Differential Diagnosis of Causes of Leg swelling

Complete Differential Diagnosis of the Causes of Leg swelling

(By organ system)

Cardiovascular	Arteriovenous Fistula , Cardiomyopathy, Chronic Venous insufficiency , Constrictive pericarditis, Cor pulmonale, Ischemia , Kawasaki disease, Kawasaki syndrome, left ventricular failure, May-Thurner syndrome, Mitral Stenosis , Phlebitis, Phlebothrombosis , Phlegmasia cerulea dolens, Postischemic , Post-thrombotic syndrome, Systemic vasculitis , Thrombophlebitis , Thrombosis in the vena cava , Uncompensated hypertension , Varicosis , Venous insufficiency
Chemical / poisoning	No underlying causes
Dermatologic	Angioneurotic edema , erysipelas, Erythema nodosum, Erythromelalgia, hereditary lymphedema, Hypertrophic osteopathy, idiopathic edema, ishemic leg edemas, Lymphedema, Sebaceous cyst, Secondary lymphatic blockage , Thrombophlebitis, Phlebothrombosis , Varicosis , Elephantiasis due to filaria
Drug Side Effect	Abacavir, Acebutolol (patient information), Acitretin (patient information), Acyclovir (patient information), Adalimumab Injection (patient information), Adderall, Albuterol (patient information), Alfuzosin (patient information), Aliskiren, Aliskiren (patient information), Aliskiren (patient information), Alitretinoin (patient information), Amantadine (patient information), Amiodarone, Amlodipine (patient information), Amlodipine and Benazepril (patient information), Anagrelide (patient information), Anastrozole (patient information), Aripiprazole (patient information), Asparaginase (patient information), Atenolol (patient information), Atorvastatin (patient information), Azithromycin, Benazepril (patient information), Bepridil (patient information), Bicalutamide (patient information), Bisoprolol (patient information), Bortezomib (patient information), Candesartan (patient information), Capecitabine (patient information), Carboplatin (patient information), Carmustine (patient information), Carvedilol (patient information), Caspofungin, Chondroitin sulfate, Cidofovir Injection (patient information), Cilostazol (patient information), Ciprofloxacin, Clarithromycin, Clopidogrel (patient information), Cyanocobalamin Injection (patient information), Cyclosporine (patient information), Cytomegalovirus Immune Globulin Intravenous Injection (patient information), Danazol (patient information), Deferasirox (patient information), Dexamethasone Oral (patient information), Diclofenac and Misoprostol (patient information), Didanosine (patient information), Diethylpropion (patient information), Diflunisal, Digoxin Oral (patient information), Diltiazem (patient information), Diphenoxylate and Atropine (patient information), Disopyramide (patient information), Doxazosin (patient information), Enalapril (patient information), Enalapril and Felodipine (patient information), Enalapril and Hydrochlorothiazide (patient information), Eprosartan (patient information), Esomeprazole (patient information), Eszopiclone (patient information), Etanercept Injection (patient information), Etidronate (patient information), Etodolac (patient information), Exenatide Injection (patient information), Ezetimibe (patient information), Famotidine (patient information), Felodipine (patient information), Fenoprofen (patient information), Fexofenadine (patient information), Fexofenadine and Pseudoephedrine (patient information), Fluconazole (patient information), Fluorouracil (patient information), Flutamide (patient information), Fluticasone and Salmeterol Oral Inhalation (patient information), Fluticasone Oral Inhalation (patient information), Fluvastatin (patient information), Formoterol (patient information), Fosinopril (patient information), Gabapentin, Ganciclovir (patient information), Gatifloxacin (patient information), Gefitinib (patient information), Gemcitabine Hydrochloride (patient information), Glatiramer Injection (patient information), Histrelin Injection (patient information), Hydrocortisone Injection (patient information), Hydrocortisone Oral (patient information), Hydrocortisone, Neomycin, and Polymyxin (patient information), Hydroxyurea (patient information), Imatinib (patient information), Imiglucerase Injection (patient information), Indomethacin (patient information), Infliximab Injection (patient information), Insulin Glulisine (rDNA origin) Injection (patient information), Interferon Beta-1b Injection (patient information), Interferon Gamma-1b Injection (patient information), Ipratropium and Albuterol Inhalation (patient information), Ipratropium Oral Inhalation (patient information), Irbesartan (patient information), Isradipine (patient information), Labetalol Oral (patient information), Lamotrigine (patient information), Lansoprazole/clarithromycin/amoxicillin (patient information), Letrozole (patient information), Leuprolide (patient information), Levocarnitine Injection (patient information), Levodopa and Carbidopa (patient information), Levofloxacin Injection (patient information), Levofloxacin Oral (patient information), Lisinopril (patient information), Lisinopril and Hydrochlorothiazide (patient information), Lithium (patient information), Lomefloxacin (patient information), Loratadine (patient information), Losartan (patient information), Losartan and Hydrochlorothiazide (patient information), Lovastatin (patient information), Meclofenamate (patient information), Medroxyprogesterone (patient information), Mefenamic acid, Mesalamine (patient information), Metoclopramide Hydrochloride Injection (patient information), Metoprolol, Mitomycin (patient information), Modafinil (patient information), Moexipril (patient information), Mycophenolate (patient information), Nabumetone (patient information), Nadolol (patient information), Natalizumab injection (patient information), Nevirapine (patient information), Nicardipine (patient information), Nifedipine (patient information), Nisoldipine (patient information), Norethindrone (patient information), Norfloxacin (patient information), Olanzapine (patient information), Olmesartan (patient information), Omeprazole (patient information), Ondansetron (patient information), Oxandrolone, Oxaprozin, Oxcarbazepine (patient information), Oxiconazole (patient information), Oxybutynin (patient information), Oxycodone and aspirin (patient information), Palifermin (patient information), Pamidronate injection (patient information), Pancrelipase, Pegaspargase (patient information), Peginterferon alfa-2a (patient information), Peginterferon alfa-2b (patient information), Perindopril (patient information), Phenazopyridine (patient information), Phenelzine (patient information), Phentermine (patient information), Phenytoin oral (patient information), Pimecrolimus topical (patient information), Pindolol (patient information), Piroxicam (patient information), Posaconazole (patient information), Pramipexole (patient information), Pramoxine (patient information), Pravastatin (patient information), Prednisolone, Prednisone, Pregabalin (patient information), Propranolol Oral (patient information), Propylthiouracil (patient information), Quinapril (patient information), Raloxifene, Ramipril, Ribavirin (patient information), Risedronate (patient information), Ritonavir (patient information), Ropinirole (patient information), Rosuvastatin (patient information), Salsalate (patient information), Sargramostim injection (patient information), Sibutramine (patient information), Simvastatin (patient information), Sirolimus (patient information), Sodium bicarbonate (patient information), Solifenacin (patient information), Sotalol (patient information), Sulfinpyrazone (patient information), Sulindac (patient information), Sunitinib (patient information), Tacrolimus topical (patient information), Tamoxifen (patient information), Tamsulosin (patient information), Telithromycin (patient information), Telmisartan (patient information), Temozolomide (patient information), Terazosin (patient information), Testosterone Buccal (patient information), Testosterone Topical (patient information), Thioguanine (patient information), Tiludronate (patient information), Timolol Oral (patient information), Tinidazole (patient information), Tolmetin, Trandolapril (patient information), Tranylcypromine (patient information), Trazodone (patient information), Triamcinolone Oral (patient information), Triamcinolone Topical (patient information), Valganciclovir (patient information), Valsartan (patient information), Vardenafil (patient information), Verapamil, Verapamil and Trandolapril (patient information), Voriconazole (patient information), Vorinostat (patient information), Zanamivir Inhalation (patient information),Zoledronic Acid Injection (patient information)|-
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, Diabetic nephropathy, Graves' Disease, hyperaldosteronism, hyperthyroidism, hypothyroidism, Myxedema
Environmental	heat, Allergy, Bee sting
Gastroenterologic	Ascites, exudative enteropathy, Hernia, Hypoalbuminemia, Liver disease with synthesis disorder or portal vein stasis , Malabsorption , Protein-Losing Enteropathy
Genetic	Turner's Syndrome
Hematologic	Deep Vein Thrombosis, Pernicious anemia
Iatrogenic	No underlying causes
Infectious Disease	Adenitis, Bubonic plague, Cellulitis, African Trypanosomiasis, Bubo, Dracunculiasis, elephantiasis, Elephantiasis due to filaria , filariasis, Handigodu Syndrome, erysipelas
Musculoskeletal / Ortho	Baker's cyst , Bursitis, Compartment syndrome, Compartment syndrome, Ewings sarcoma, Fuchs' dystrophy, Ganglion cyst, Giant cell tumor of bone, Iliotibial band syndrome, Infantile cortical hyperostosis, Kohler disease, Meniscal cyst, Myorrhexis , Osteoblastoma, Osteochondroma, Osteochondrosis, Osteosarcoma, Palindromic rheumatism, Pigmented villonodular synovitis, Psoriatic arthritis, Sudeck's atrophy , Synovial osteochondromatosis, Synovial sarcoma, Water on knee
Neurologic	No underlying causes
Nutritional / Metabolic	Beriberi, Beriberi Heart Disease, Malnutrition , Obesity hypoventilation syndrome
Obstetric/Gynecologic	Pre-eclampsia, edema proteinuria hypertension (EPH) gestosis, Pregnancy, Premenstrual
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	Cladribine (patient information), Atenolol (patient information), Bisoprolol (patient information), Cyclosporine (patient information), Ganciclovir (patient information), Metoprolol, Nadolol (patient information), Nifedipine (patient information), Oxycodone and aspirin (patient information), Palifermin (patient information), Propylthiouracil (patient information)
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	Congenital nephrotic syndrome, glomerulonephritis, Lupus nephritis, Nephrotic Syndrome , Renal failure
Rheum / Immune / Allergy	Allergic Reaction, Allergy, Bee sting, Omenn syndrome, Reiter's Disease:Patient Information, Gout, Diabetic nephropathy, Hypoalbuminemia
Sexual	No underlying causes
Trauma	Local trauma , Posttraumatic
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	After radiation therapy , Benign tumor, cancer, Chemotherapy, hyperhydration, Insect bite and stings, Neoplastic , Orthostatic , Palmar plantar erythrodysesthesia, Postoperative , Tumor compression , Tumor in the area of the hypogastrium , Hernia, Angioneurotic edema , idiopathic edema, ishemic leg edemas, Secondary lymphatic blockage , Hypoalbuminemia

(In alphabetical order)

• Abacavir

• Acebutolol (patient information)

• Acitretin (patient information)

• Acyclovir (patient information)

• Adalimumab Injection (patient information)

• Adderall

• Adenitis

• African Trypanosomiasis

• After radiation therapy

• Albuterol (patient information)

• Alfuzosin (patient information)

• Aliskiren

• Aliskiren (patient information)

• Aliskiren (patient information)

• Alitretinoin (patient information)

• Allergic Reaction

• Allergy

• Amantadine (patient information)

• Amiodarone

• Amlodipine (patient information)

• Amlodipine and Benazepril (patient information)

• Anagrelide (patient information)

• Anastrozole (patient information)

• Angioneurotic edema

• Aripiprazole (patient information)

• Arteriovenous Fistula

• Ascites

• Asparaginase (patient information)

• Atenolol (patient information)

• Atorvastatin (patient information)

• Azithromycin

• Baker's cyst

• Bee sting

• Benazepril (patient information)

• Benign tumor

• Bepridil (patient information)

• Beriberi

• Beriberi Heart Disease

• Bicalutamide (patient information)

• Bisoprolol (patient information)

• Bortezomib (patient information)

• Bubo

• Bubonic plague

• Bursitis

• cancer

• Candesartan (patient information)

• Capecitabine (patient information)

• Carboplatin (patient information)

• Cardiomyopathy

• Carmustine (patient information)

• Carvedilol (patient information)

• Caspofungin

• Cellulitis

• Chemotherapy

• Chondroitin sulfate

• Chronic Venous insufficiency

• Cidofovir Injection (patient information)

• Cilostazol (patient information)

• Ciprofloxacin

• Cladribine (patient information)

• Clarithromycin

• Clopidogrel (patient information)

• Compartment syndrome

• Compartment syndrome

• Congenital nephrotic syndrome

• Constrictive pericarditis

• Cor pulmonale

• Cyanocobalamin Injection (patient information)

• Cyclosporine (patient information)

• Cytomegalovirus Immune Globulin Intravenous Injection (patient information)

• Danazol (patient information)

• Deep Vein Thrombosis

• Deferasirox (patient information)

• Dexamethasone Oral (patient information)

• Diabetes mellitus

• Diabetic nephropathy

• Diclofenac and Misoprostol (patient information)

• Didanosine (patient information)

• Diethylpropion (patient information)

• Diflunisal

• Digoxin Oral (patient information)

• Diltiazem (patient information)

• Diphenoxylate and Atropine (patient information)

• Disopyramide (patient information)

• Doxazosin (patient information)

• Dracunculiasis

• edema proteinuria hypertension (EPH) gestosis

• elephantiasis

• Elephantiasis due to filaria

• Enalapril (patient information)

• Enalapril and Felodipine (patient information)

• Enalapril and Hydrochlorothiazide (patient information)

• Eprosartan (patient information)

• erysipelas

• Erythema nodosum

• Erythromelalgia

• Esomeprazole (patient information)

• Eszopiclone (patient information)

• Etanercept Injection (patient information)

• Etidronate (patient information)

• Etodolac (patient information)

• Ewings sarcoma

• Exenatide Injection (patient information)

• exudative enteropathy

• Ezetimibe (patient information)

• Famotidine (patient information)

• Felodipine (patient information)

• Fenoprofen (patient information)

• Fexofenadine (patient information)

• Fexofenadine and Pseudoephedrine (patient information)

• filariasis

• Fluconazole (patient information)

• Fluorouracil (patient information)

• Flutamide (patient information)

• Fluticasone and Salmeterol Oral Inhalation (patient information)

• Fluticasone Oral Inhalation (patient information)

• Fluvastatin (patient information)

• Formoterol (patient information)

• Fosinopril (patient information)

• Fuchs' dystrophy

• Gabapentin

• Ganciclovir (patient information)

• Ganglion cyst

• Gatifloxacin (patient information)

• Gefitinib (patient information)

• Gemcitabine Hydrochloride (patient information)

• Giant cell tumor of bone

• Glatiramer Injection (patient information)

• glomerulonephritis

• Gout

• Graves' Disease

• Handigodu Syndrome

• heat

• hereditary lymphedema

• Hernia

• Histrelin Injection (patient information)

• Hydrocortisone Injection (patient information)

• Hydrocortisone Oral (patient information)

• Hydrocortisone, Neomycin, and Polymyxin (patient information)

• Hydroxyurea (patient information)

• hyperaldosteronism

• hyperhydration

• hyperthyroidism

• Hypertrophic osteopathy

• Hypoalbuminemia

• hypothyroidism

• idiopathic edema

• Iliotibial band syndrome

• Imatinib (patient information)

• Imiglucerase Injection (patient information)

• Indomethacin (patient information)

• Infantile cortical hyperostosis

• Infliximab Injection (patient information)

• Insect bite and stings

• Insulin Glulisine (rDNA origin) Injection (patient information)

• Interferon Beta-1b Injection (patient information)

• Interferon Gamma-1b Injection (patient information)

• Ipratropium and Albuterol Inhalation (patient information)

• Ipratropium Oral Inhalation (patient information)

• Irbesartan (patient information)

• Ischemia

• ishemic leg edemas

• Isradipine (patient information)

• Kohler disease

• Kawasaki disease

• Kawasaki syndrome

• Labetalol Oral (patient information)

• Lamotrigine (patient information)

• Lansoprazole/clarithromycin/amoxicillin (patient information)

• left ventricular failure

• Letrozole (patient information)

• Leuprolide (patient information)

• Levocarnitine Injection (patient information)

• Levodopa and Carbidopa (patient information)

• Levofloxacin Injection (patient information)

• Levofloxacin Oral (patient information)

• Lisinopril (patient information)

• Lisinopril and Hydrochlorothiazide (patient information)

• Lithium (patient information)

• Liver disease with synthesis disorder or portal vein stasis

• Local trauma

• Lomefloxacin (patient information)

• Loratadine (patient information)

• Losartan (patient information)

• Losartan and Hydrochlorothiazide (patient information)

• Lovastatin (patient information)

• Lupus nephritis

• Lymphedema

• Malabsorption

• Malnutrition

• May-Thurner syndrome

• Meclofenamate (patient information)

• Medroxyprogesterone (patient information)

• Mefenamic acid

• Meniscal cyst

• Mesalamine (patient information)

• Metoclopramide Hydrochloride Injection (patient information)

• Metoprolol

• Mitomycin (patient information)

• Mitral Stenosis

• Modafinil (patient information)

• Moexipril (patient information)

• Mycophenolate (patient information)

• Myorrhexis

• Myxedema

• Nabumetone (patient information)

• Nadolol (patient information)

• Natalizumab injection (patient information)

• Neoplastic

• Nephrotic Syndrome

• Nevirapine (patient information)

• Nicardipine (patient information)

• Nifedipine (patient information)

• Nisoldipine (patient information)

• Norethindrone (patient information)

• Norfloxacin (patient information)

• Obesity hypoventilation syndrome

• Olanzapine (patient information)

• Olmesartan (patient information)

• Omenn syndrome

• Omeprazole (patient information)

• Ondansetron (patient information)

• Orthostatic

• Osteoblastoma

• Osteochondroma

• Osteochondrosis

• Osteosarcoma

• Oxandrolone

• Oxaprozin

• Oxcarbazepine (patient information)

• Oxiconazole (patient information)

• Oxybutynin (patient information)

• Oxycodone and aspirin (patient information)

• Palifermin (patient information)

• Palindromic rheumatism

• Palmar plantar erythrodysesthesia

• Pamidronate injection (patient information)

• Pancrelipase

• Pegaspargase (patient information)

• Peginterferon alfa-2a (patient information)

• Peginterferon alfa-2b (patient information)

• Perindopril (patient information)

• Pernicious anemia

• Phenazopyridine (patient information)

• Phenelzine (patient information)

• Phentermine (patient information)

• Phenytoin oral (patient information)

• Phlebitis

• Phlebothrombosis

• Phlegmasia cerulea dolens

• Pigmented villonodular synovitis

• Pimecrolimus topical (patient information)

• Pindolol (patient information)

• Piroxicam (patient information)

• Posaconazole (patient information)

• Postischemic

• Postoperative

• Post-thrombotic syndrome

• Posttraumatic

• Pramipexole (patient information)

• Pramoxine (patient information)

• Pravastatin (patient information)

• Prednisolone

• Prednisone

• Pre-eclampsia

• Pregabalin (patient information)

• Pregnancy

• Premenstrual

• Propranolol Oral (patient information)

• Propylthiouracil (patient information)

• Protein-Losing Enteropathy

• Psoriatic arthritis

• Quinapril (patient information)

• Raloxifene

• Ramipril

• Reiter's Disease:Patient Information

• Renal failure

• Ribavirin (patient information)

• Risedronate (patient information)

• Ritonavir (patient information)

• Ropinirole (patient information)

• Rosuvastatin (patient information)

• Salsalate (patient information)

• Sargramostim injection (patient information)

• Sebaceous cyst

• Secondary lymphatic blockage

• Sibutramine (patient information)

• Simvastatin (patient information)

• Sirolimus (patient information)

• Sodium bicarbonate (patient information)

• Solifenacin (patient information)

• Sotalol (patient information)

• Sudeck's atrophy

• Sulfinpyrazone (patient information)

• Sulindac (patient information)

• Sunitinib (patient information)

• Synovial osteochondromatosis

• Synovial sarcoma

• Systemic vasculitis

• Tacrolimus topical (patient information)

• Tamoxifen (patient information)

• Tamsulosin (patient information)

• Telithromycin (patient information)

• Telmisartan (patient information)

• Temozolomide (patient information)

• Terazosin (patient information)

• Testosterone Buccal (patient information)

• Testosterone Topical (patient information)

• Thioguanine (patient information)

• Thrombophlebitis

• Thrombosis in the vena cava

• Tiludronate (patient information)

• Timolol Oral (patient information)

• Tinidazole (patient information)

• Tolmetin

• Trandolapril (patient information)

• Tranylcypromine (patient information)

• Trazodone (patient information)

• Triamcinolone Oral (patient information)

• Triamcinolone Topical (patient information)

• Tumor compression

• Tumor in the area of the hypogastrium

• Turner's Syndrome

• Uncompensated hypertension

• Valganciclovir (patient information)

• Valsartan (patient information)

• Vardenafil (patient information)

• Varicosis

• Venous insufficiency

• Verapamil

• Verapamil and Trandolapril (patient information)

• Voriconazole (patient information)

• Vorinostat (patient information)

• Water on knee

• Zanamivir Inhalation (patient information)

• Zoledronic Acid Injection (patient information)

Unilateral

• After radiation therapy
• Angioneurotic edema
• Arteriovenous Fistula
• Baker's cyst
• Cellulitis
• Compartment syndrome
• Elephantiasis due to filariae
• Erysipelas
• Hereditary lymphedema
• Insect bites
• Ischemia
• Local trauma
• Myorrhexis
• Neoplastic
• Phlebothrombosis
• Post-thrombotic syndrome
• Postischemic
• Postoperative
• Posttraumatic
• Secondary lymphatic blockage
• Sudeck's atrophy
• Thrombophlebitis
• Tumor compression
• Varicosis
• Venous insufficiency