Amenorrhea causes: Difference between revisions
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==Causes== | ==Causes== | ||
=== Primary | === Primary Amenorrhea === | ||
* [[17 beta-hydroxysteroid dehydrogenase deficiency]] | * [[17 beta-hydroxysteroid dehydrogenase deficiency]] | ||
* [[Agonadism]] | * [[Agonadism]] | ||
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* [[Vaginal atresia]] / gynatresia | * [[Vaginal atresia]] / gynatresia | ||
=== Secondary | === Secondary Amenorrhea === | ||
* [[5-alpha-reductase deficiency]] | * [[5-alpha-reductase deficiency]] | ||
* Addiction | * Addiction | ||
Revision as of 15:04, 22 August 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Primary Amenorrhea
- 17 beta-hydroxysteroid dehydrogenase deficiency
- Agonadism
- After trauma
- Anorexia Nervosa
- Anovulation
- Complete androgen insenstivity syndrome
- Constitutional bradygenesis
- Constitutional delay of puberty
- Diabetes Mellitus
- Early infantile brain damage
- Gonadal dysgenesis
- Homozygous adrenogenital syndrome
- Hymenal atresia
- Hyperandrogenism
- Hypothalamic and pituitary tumors
- Idiopathic gonadotropin deficiency
- Kallmann's Syndrome
- Mayer-Rokitansky-Hauser Syndrome
- Mullerian dysgenesis
- Outflow tract disorders
- Pituitary insufficiency
- Polycystic Ovary Syndrome
- Post-hormonal contraceptive Amenorrhea
- Severe systemic diseases
- Swyer's Syndrome
- Testicular feminization
- Turner's Syndrome
- Uterine atresia
- Uterine hypoplasia
- Vaginal atresia / gynatresia
Secondary Amenorrhea
- 5-alpha-reductase deficiency
- Addiction
- Addison's Disease
- Adrenocortical insuffiency
- After curettage
- After hysterectomy
- After radiation (can be reversed)
- Adrenal tumors
- Anovulation
- Asherman's Syndrome
- Autoimmune diseases
- Body building (and use of androgens)
- Castration (radiation or surgical)
- Central nervous system tumor (CNS)
- Cervical stenosis
- Change of environment
- Complete and incomplete androgen insensitivity
- Congenital adrenal hyperplasia
- Craniocerebral trauma
- Cushing's Syndrome
- Depression
- Diabetes Mellitus
- Encephalitis
- Enzymatic defects in testosterone biosynthesis
- Exposure to maternal androgens in utero
- Extreme obesity
- During chemotherapy
- Functional hypothalalmic Amenorrhea due to:
- Stress
- Eating disorders
- Excessive exercise
- Weight loss
- Gonadotropin deficiency in tumors
- Hormone-active ovarian tumor
- Hermaphroditism
- Heterozygous adrenogenital syndrome
- Hyperprolactinemia
- Hyperthyroidism
- Hypothyroidism
- Hysterectomy
- Imprisonment
- Meningitis
- Mullerian anomalies
- Myotonic dystrophy
- Pituitary insufficiency
- Polycystic ovary syndrome
- Post-hormonal contraception
- Post-infection (mumps, severe pelvic inflammatory disease)
- Postoerative gonadotropin deficiency
- Pregnancy
- Premature menopause
- Prolactinoma
- Sheehan's Syndrome
- Stress
- Testicular feminization
- Transsexuality when taking androgens
- Turner's Syndrome
- Uterine cavity sclerosis
- Uterine Schistosomiasis
- Abortion
- Severe generalized infections of the pelvis
- Post uterine surgery
- Overzealous or repeated uterine curettage
- Tuberculosis endometritis
Differential Diagnosis Organized by Category of Causes
- Physiologic
- Hypothalamic
- Structural
- Functional
- Anorexia/bulimia
- Excessive exercise/weight loss
- Stress
- Pituitary
- Secretory tumors
- Destructive lesions
- Non-functional tumors
- Sheehan's syndrome
- Hemochromatosis
- Ovarian
- Premature ovarian failure
- Hyperandrogenic disorders
- polycystic ovary syndrome (PCOS)
- Nonclassical congenital adrenal hyperplasia (NCCAH)
- Adrenal/ovarian androgen-secreting tumors
- Anatomic
- Destruction of uterine cavity
- Other