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| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1| url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9619| accessdate = }}</ref>
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==Overview==
'''ATP-binding cassette, sub-family G (WHITE), member 1''', also known as '''ABCG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9619| accessdate = }}</ref>
'''ATP-binding cassette, sub-family G (WHITE), member 1''', also known as '''ABCG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9619| accessdate = }}</ref>
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| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9619| accessdate = }}</ref>
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==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{Reflist|2}}


==Further reading==
==Further reading==

Revision as of 18:50, 25 September 2013

ATP-binding cassette, sub-family G (WHITE), member 1
Identifiers
Symbols ABCG1 ; ABC8; MGC34313; WHITE1
External IDs Template:OMIM5 Template:MGI HomoloGene: 21022
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.[1]

Overview

ATP-binding cassette, sub-family G (WHITE), member 1, also known as ABCG1, is a human gene.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1".

Further reading

  • Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism". J. Lipid Res. 42 (10): 1513–20. PMID 11590207.
  • Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Chen H, Rossier C, Lalioti MD; et al. (1996). "Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3". Am. J. Hum. Genet. 59 (1): 66–75. PMID 8659545.
  • Savary S, Denizot F, Luciani M; et al. (1996). "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene". Mamm. Genome. 7 (9): 673–6. PMID 8703120.
  • Croop JM, Tiller GE, Fletcher JA; et al. (1997). "Isolation and characterization of a mammalian homolog of the Drosophila white gene". Gene. 185 (1): 77–85. PMID 9034316.
  • Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
  • Klucken J, Büchler C, Orsó E; et al. (2000). "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 817–22. PMID 10639163.
  • Venkateswaran A, Repa JJ, Lobaccaro JM; et al. (2000). "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols". J. Biol. Chem. 275 (19): 14700–7. PMID 10799558.
  • Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Berry A, Scott HS, Kudoh J; et al. (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics. 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923.
  • Langmann T, Porsch-Ozcürümez M, Unkelbach U; et al. (2000). "Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene". Biochim. Biophys. Acta. 1494 (1–2): 175–80. PMID 11072082.
  • Lorkowski S, Rust S, Engel T; et al. (2001). "Genomic sequence and structure of the human ABCG1 (ABC8) gene". Biochem. Biophys. Res. Commun. 280 (1): 121–31. doi:10.1006/bbrc.2000.4089. PMID 11162488.
  • Porsch-Ozcurumez M, Langmann T, Heimerl S; et al. (2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". J. Biol. Chem. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
  • Lorkowski S, Kratz M, Wenner C; et al. (2001). "Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease". Biochem. Biophys. Res. Commun. 283 (4): 821–30. doi:10.1006/bbrc.2001.4863. PMID 11350058.
  • Kennedy MA, Venkateswaran A, Tarr PT; et al. (2001). "Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein". J. Biol. Chem. 276 (42): 39438–47. doi:10.1074/jbc.M105863200. PMID 11500512.
  • Kaplan R, Gan X, Menke JG; et al. (2003). "Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway". J. Lipid Res. 43 (6): 952–9. PMID 12032171.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Cserepes J, Szentpétery Z, Seres L; et al. (2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization". Biochem. Biophys. Res. Commun. 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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