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{{ | CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. | ||
'''Ubiquitin-conjugating enzyme E2 R1''' is a [[protein]] that in humans is encoded by the ''CDC34'' [[gene]].<ref name="pmid8248134">{{cite journal | vauthors = Plon SE, Leppig KA, Do HN, Groudine M | title = Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 22 | pages = 10484–8 |date=Dec 1993 | pmid = 8248134 | pmc = 47801 | doi =10.1073/pnas.90.22.10484 }}</ref><ref name="pmid16210246">{{cite journal | vauthors = Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ | title = Proximity-induced activation of human Cdc34 through heterologous dimerization | journal = Proc Natl Acad Sci U S A | volume = 102 | issue = 42 | pages = 15053–8 |date=Oct 2005 | pmid = 16210246 | pmc = 1242854 | doi = 10.1073/pnas.0507646102 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=997| accessdate = }}</ref> | |||
}} | |||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.<ref name="entrez">{{cite web | title = Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)| url = | | summary_text = The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.<ref name="entrez">{{cite web | title = Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=997| accessdate = }}</ref> | ||
}} | }} | ||
==Interactions== | |||
CDC34 has been shown to [[Protein-protein interaction|interact]] with [[CSNK2B]],<ref name=pmid11546811>{{cite journal |last=Block |first=K |author2=Boyer T G|author3=Yew P R |date=Nov 2001 |title=Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2 |journal=J. Biol. Chem. |volume=276 |issue=44 |pages=41049–58 |publisher= |location = United States| issn = 0021-9258| pmid = 11546811 |doi = 10.1074/jbc.M106453200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BTRC (gene)|BTRC]]<ref name=pmid12037680>{{cite journal |last=Semplici |first=Francesca |author2=Meggio Flavio |author3=Pinna Lorenzo A |author4=Oliviero Salvatore |date=Jun 2002 |title=CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation |journal=Oncogene |volume=21 |issue=25 |pages=3978–87 |publisher= |location = England| issn = 0950-9232| pmid = 12037680 |doi = 10.1038/sj.onc.1205574 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10531035>{{cite journal |last=Cenciarelli |first=C |author2=Chiaur D S|author3=Guardavaccaro D|author4=Parks W|author5=Vidal M|author6=Pagano M |date=Oct 1999 |title=Identification of a family of human F-box proteins |journal=Curr. Biol. |volume=9 |issue=20 |pages=1177–9 |publisher= |location = ENGLAND| issn = 0960-9822| pmid = 10531035 |doi = 10.1016/S0960-9822(00)80020-2 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[CDK9]].<ref name=pmid11689688>{{cite journal |last=Kiernan |first=R E |author2=Emiliani S |author3=Nakayama K |author4=Castro A |author5=Labbé J C |author6=Lorca T |author7=Nakayama Ki K |author8=Benkirane M |date=Dec 2001 |title=Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome |journal=Mol. Cell. Biol. |volume=21 |issue=23 |pages=7956–70 |publisher= |location = United States| issn = 0270-7306| pmid = 11689688 |doi = 10.1128/MCB.21.23.7956-7970.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99964 }}</ref> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CDC34}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=King RW, Deshaies RJ, Peters JM, Kirschner MW |title=How proteolysis drives the cell cycle. |journal=Science |volume=274 |issue= 5293 |pages= 1652–9 |year= 1997 |pmid= 8939846 |doi=10.1126/science.274.5293.1652 }} | ||
*{{cite journal | author=Pagano M |title=Cell cycle regulation by the ubiquitin pathway. |journal=FASEB J. |volume=11 |issue= 13 |pages= | *{{cite journal | author=Pagano M |title=Cell cycle regulation by the ubiquitin pathway. |journal=FASEB J. |volume=11 |issue= 13 |pages= 1067–75 |year= 1997 |pmid= 9367342 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Lisztwan J, Marti A, Sutterlüty H |title=Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. |journal=EMBO J. |volume=17 |issue= 2 |pages= 368–83 |year= 1998 |pmid= 9430629 |doi= 10.1093/emboj/17.2.368 | pmc=1170388 |display-authors=etal}} | ||
*{{cite journal | vauthors=Song A, Wang Q, Goebl MG, Harrington MA |title=Phosphorylation of nuclear MyoD is required for its rapid degradation. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 4994–9 |year= 1998 |pmid= 9710583 |doi= | pmc=109084 }} | |||
*{{cite journal | | *{{cite journal | vauthors=Gonen H, Bercovich B, Orian A |title=Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14823–30 |year= 1999 |pmid= 10329681 |doi=10.1074/jbc.274.21.14823 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Pati D, Meistrich ML, Plon SE |title=Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5001–13 |year= 1999 |pmid= 10373550 |doi= 10.1128/mcb.19.7.5001| pmc=84326 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Seol JH, Feldman RM, Zachariae W |title=Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. |journal=Genes Dev. |volume=13 |issue= 12 |pages= 1614–26 |year= 1999 |pmid= 10385629 |doi=10.1101/gad.13.12.1614 | pmc=316801 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Read MA, Brownell JE, Gladysheva TB |title=Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2326–33 |year= 2000 |pmid= 10713156 |doi=10.1128/MCB.20.7.2326-2333.2000 | pmc=85397 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Reymond F, Wirbelauer C, Krek W |title=Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase. |journal=J. Cell Sci. |volume=113 |issue= 10|pages= 1687–94 |year= 2000 |pmid= 10769200 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Charrasse S, Carena I, Brondani V |title=Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway. |journal=Oncogene |volume=19 |issue= 26 |pages= 2986–95 |year= 2000 |pmid= 10871850 |doi= 10.1038/sj.onc.1203618 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strack P, Caligiuri M, Pelletier M |title=SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4. |journal=Oncogene |volume=19 |issue= 31 |pages= 3529–36 |year= 2000 |pmid= 10918611 |doi= 10.1038/sj.onc.1203647 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Duan W, Sun B, Li TW |title=Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. |journal=Gene |volume=256 |issue= 1-2 |pages= 113–21 |year= 2001 |pmid= 11054541 |doi=10.1016/S0378-1119(00)00365-6 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Block K, Boyer TG, Yew PR |title=Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41049–58 |year= 2001 |pmid= 11546811 |doi= 10.1074/jbc.M106453200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Wu K, Chen A, Tan P, Pan ZQ |title=The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 516–27 |year= 2002 |pmid= 11675391 |doi= 10.1074/jbc.M108008200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kiernan RE, Emiliani S, Nakayama K |title=Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 7956–70 |year= 2001 |pmid= 11689688 |doi= 10.1128/MCB.21.23.7956-7970.2001 | pmc=99964 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Semplici F, Meggio F, Pinna LA, Oliviero S |title=CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. |journal=Oncogene |volume=21 |issue= 25 |pages= 3978–87 |year= 2002 |pmid= 12037680 |doi= 10.1038/sj.onc.1205574 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=997}} | |||
{{Ubiquitin-conjugating enzymes}} | |||
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{{ | {{gene-19-stub}} | ||
Revision as of 19:31, 8 November 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.[1][2][3]
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]
Interactions
CDC34 has been shown to interact with CSNK2B,[4] BTRC[5][6] and CDK9.[7]
References
- ↑ Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A. 90 (22): 10484–8. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
- ↑ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A. 102 (42): 15053–8. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
- ↑ 3.0 3.1 "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
- ↑ Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. United States. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811.
- ↑ Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. England. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680.
- ↑ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. ENGLAND. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035.
- ↑ Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. United States. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688.
External links
- Human CDC34 genome location and CDC34 gene details page in the UCSC Genome Browser.
Further reading
- King RW, Deshaies RJ, Peters JM, Kirschner MW (1997). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. doi:10.1126/science.274.5293.1652. PMID 8939846.
- Pagano M (1997). "Cell cycle regulation by the ubiquitin pathway". FASEB J. 11 (13): 1067–75. PMID 9367342.
- Lisztwan J, Marti A, Sutterlüty H, et al. (1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway". EMBO J. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMC 1170388. PMID 9430629.
- Song A, Wang Q, Goebl MG, Harrington MA (1998). "Phosphorylation of nuclear MyoD is required for its rapid degradation". Mol. Cell. Biol. 18 (9): 4994–9. PMC 109084. PMID 9710583.
- Gonen H, Bercovich B, Orian A, et al. (1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha". J. Biol. Chem. 274 (21): 14823–30. doi:10.1074/jbc.274.21.14823. PMID 10329681.
- Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
- Seol JH, Feldman RM, Zachariae W, et al. (1999). "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34". Genes Dev. 13 (12): 1614–26. doi:10.1101/gad.13.12.1614. PMC 316801. PMID 10385629.
- Read MA, Brownell JE, Gladysheva TB, et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Mol. Cell. Biol. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
- Reymond F, Wirbelauer C, Krek W (2000). "Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase". J. Cell Sci. 113 (10): 1687–94. PMID 10769200.
- Charrasse S, Carena I, Brondani V, et al. (2000). "Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway". Oncogene. 19 (26): 2986–95. doi:10.1038/sj.onc.1203618. PMID 10871850.
- Strack P, Caligiuri M, Pelletier M, et al. (2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
- Duan W, Sun B, Li TW, et al. (2001). "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo". Gene. 256 (1–2): 113–21. doi:10.1016/S0378-1119(00)00365-6. PMID 11054541.
- Block K, Boyer TG, Yew PR (2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
- Wu K, Chen A, Tan P, Pan ZQ (2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34". J. Biol. Chem. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
- Kiernan RE, Emiliani S, Nakayama K, et al. (2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
- Semplici F, Meggio F, Pinna LA, Oliviero S (2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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