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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitogen-activated protein kinase kinase kinase 1''' is an [[enzyme]] that in humans is encoded by the ''MAP3K1'' [[gene]].<ref name="pmid8597633">{{cite journal | vauthors = Vinik BS, Kay ES, Fiedorek FT | title = Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5 | journal = Mammalian Genome | volume = 6 | issue = 11 | pages = 782–3 | date = Nov 1995 | pmid = 8597633 | pmc = | doi = 10.1007/BF00539003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4214| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 1
| HGNCid = 6848
| Symbol = MAP3K1
| AltSymbols =; MAPKKK1; MEKK; MEKK1
| OMIM = 600982
| ECnumber = 
| Homologene = 8056
| MGIid = 1346872
| GeneAtlas_image1 = PBB_GE_MAP3K1_214786_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004709 |text = MAP kinase kinase kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0008637 |text = apoptotic mitochondrial changes}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0030838 |text = positive regulation of actin filament polymerization}} {{GNF_GO|id=GO:0042060 |text = wound healing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4214
    | Hs_Ensembl = ENSG00000095015
    | Hs_RefseqProtein = XP_001128827
    | Hs_RefseqmRNA = XM_001128827
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 56147216
    | Hs_GenLoc_end = 56225472
    | Hs_Uniprot = Q13233
    | Mm_EntrezGene = 26401
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_011945
    | Mm_RefseqProtein = NP_036075
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Mitogen-activated protein kinase kinase kinase 1''', also known as '''MAP3K1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4214| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including [[insulin]] and many growth factors.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4214| accessdate = }}</ref>
}}


==References==
Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.
{{reflist|2}}
 
==Further reading==
== Interactions ==
{{refbegin | 2}}
 
{{PBB_Further_reading
MAP3K1 has been shown to [[Protein-protein interaction|interact]] with:
| citations =  
* [[AXIN1]],<ref name = pmid11884395>{{cite journal | vauthors = Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC | title = Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways | journal = The Journal of Biological Chemistry | volume = 277 | issue = 20 | pages = 17706–12 | date = May 2002 | pmid = 11884395 | doi = 10.1074/jbc.M111982200 }}</ref><ref name = pmid10829020>{{cite journal | vauthors = Zhang Y, Neo SY, Han J, Lin SC | title = Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 32 | pages = 25008–14 | date = Aug 2000 | pmid = 10829020 | doi = 10.1074/jbc.M002491200 }}</ref>
*{{cite journal | author=Vinik BS, Kay ES, Fiedorek FT |title=Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. |journal=Mamm. Genome |volume=6 |issue= 11 |pages= 782-3 |year= 1996 |pmid= 8597633 |doi= }}
* [[C-Raf]],<ref name = pmid10969079>{{cite journal | vauthors = Karandikar M, Xu S, Cobb MH | title = MEKK1 binds raf-1 and the ERK2 cascade components | journal = The Journal of Biological Chemistry | volume = 275 | issue = 51 | pages = 40120–7 | date = Dec 2000 | pmid = 10969079 | doi = 10.1074/jbc.M005926200 }}</ref>
*{{cite journal | author=Lee FS, Hagler J, Chen ZJ, Maniatis T |title=Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. |journal=Cell |volume=88 |issue= 2 |pages= 213-22 |year= 1997 |pmid= 9008162 |doi= }}
* [[Grb2]],<ref name = pmid9733714>{{cite journal | vauthors = Pomérance M, Multon MC, Parker F, Venot C, Blondeau JP, Tocqué B, Schweighoffer F | title = Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24301–4 | date = Sep 1998 | pmid = 9733714 | doi = 10.1074/jbc.273.38.24301}}</ref>
*{{cite journal | author=Siow YL, Kalmar GB, Sanghera JS, ''et al.'' |title=Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C. |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 7586-94 |year= 1997 |pmid= 9065412 |doi= }}
* [[MAP2K1]],<ref name = pmid10969079/>
*{{cite journal | author=Su YC, Han J, Xu S, ''et al.'' |title=NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1279-90 |year= 1997 |pmid= 9135144 |doi= 10.1093/emboj/16.6.1279 }}
* [[MAPK1]],<ref name = pmid10969079/>
*{{cite journal | author=Wu Z, Wu J, Jacinto E, Karin M |title=Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7407-16 |year= 1997 |pmid= 9372971 |doi=  }}
* [[MAPK8]],<ref name = pmid9405400>{{cite journal | vauthors = Xu S, Cobb MH | title = MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32056–60 | date = Dec 1997 | pmid = 9405400 | doi =  10.1074/jbc.272.51.32056}}</ref>
*{{cite journal | author=Xu S, Cobb MH |title=MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32056-60 |year= 1998 |pmid= 9405400 |doi=  }}
* [[TRAF2]],<ref name = pmid10346818>{{cite journal | vauthors = Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M | title = Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain | journal = Genes & Development | volume = 13 | issue = 10 | pages = 1297–308 | date = May 1999 | pmid = 10346818 | pmc = 316725 | doi =  10.1101/gad.13.10.1297}}</ref>  and
*{{cite journal | author=Fanger GR, Widmann C, Porter AC, ''et al.'' |title=14-3-3 proteins interact with specific MEK kinases. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3476-83 |year= 1998 |pmid= 9452471 |doi=  }}
* [[UBE2I]].<ref name = pmid9563508>{{cite journal | vauthors = Saltzman A, Searfoss G, Marcireau C, Stone M, Ressner R, Munro R, Franks C, D'Alonzo J, Tocque B, Jaye M, Ivashchenko Y | title = hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity | journal = FEBS Letters | volume = 425 | issue = 3 | pages = 431–5 | date = Apr 1998 | pmid = 9563508 | doi =  10.1016/s0014-5793(98)00287-7}}</ref>
*{{cite journal  | author=Hirai S, Noda K, Moriguchi T, ''et al.'' |title=Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7406-12 |year= 1998 |pmid= 9516438 |doi= }}
{{clear}}
*{{cite journal | author=Saltzman A, Searfoss G, Marcireau C, ''et al.'' |title=hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 431-5 |year= 1998 |pmid= 9563508 |doi= }}
== References ==
*{{cite journal | author=Guan Z, Buckman SY, Pentland AP, ''et al.'' |title=Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 12901-8 |year= 1998 |pmid= 9582321 |doi= }}
{{reflist|33em}}
*{{cite journal | author=Lee FS, Peters RT, Dang LC, Maniatis T |title=MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9319-24 |year= 1998 |pmid= 9689078 |doi=  }}
 
*{{cite journal | author=Yuasa T, Ohno S, Kehrl JH, Kyriakis JM |title=Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22681-92 |year= 1998 |pmid= 9712898 |doi= }}
== Further reading ==
*{{cite journal | author=Pomérance M, Multon MC, Parker F, ''et al.'' |title=Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24301-4 |year= 1998 |pmid= 9733714 |doi= }}
{{refbegin|33em}}
*{{cite journal | author=Xia Y, Wu Z, Su B, ''et al.'' |title=JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. |journal=Genes Dev. |volume=12 |issue= 21 |pages= 3369-81 |year= 1998 |pmid= 9808624 |doi= }}
* {{cite journal | vauthors = Lee FS, Hagler J, Chen ZJ, Maniatis T | title = Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway | journal = Cell | volume = 88 | issue = 2 | pages = 213–22 | date = Jan 1997 | pmid = 9008162 | doi = 10.1016/S0092-8674(00)81842-5 }}
*{{cite journal | author=Nemoto S, DiDonato JA, Lin A |title=Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7336-43 |year= 1998 |pmid= 9819420 |doi= }}
* {{cite journal | vauthors = Siow YL, Kalmar GB, Sanghera JS, Tai G, Oh SS, Pelech SL | title = Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C | journal = The Journal of Biological Chemistry | volume = 272 | issue = 12 | pages = 7586–94 | date = Mar 1997 | pmid = 9065412 | doi = 10.1074/jbc.272.12.7586 }}
*{{cite journal | author=Yujiri T, Sather S, Fanger GR, Johnson GL |title=Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. |journal=Science |volume=282 |issue= 5395 |pages= 1911-4 |year= 1998 |pmid= 9836645 |doi= }}
* {{cite journal | vauthors = Su YC, Han J, Xu S, Cobb M, Skolnik EY | title = NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain | journal = The EMBO Journal | volume = 16 | issue = 6 | pages = 1279–90 | date = Mar 1997 | pmid = 9135144 | pmc = 1169726 | doi = 10.1093/emboj/16.6.1279 }}
*{{cite journal | author=Baud V, Liu ZG, Bennett B, ''et al.'' |title=Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. |journal=Genes Dev. |volume=13 |issue= 10 |pages= 1297-308 |year= 1999 |pmid= 10346818 |doi= }}
* {{cite journal | vauthors = Wu Z, Wu J, Jacinto E, Karin M | title = Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase | journal = Molecular and Cellular Biology | volume = 17 | issue = 12 | pages = 7407–16 | date = Dec 1997 | pmid = 9372971 | pmc = 232596 | doi =  10.1128/mcb.17.12.7407}}
*{{cite journal | author=Kopp E, Medzhitov R, Carothers J, ''et al.'' |title=ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. |journal=Genes Dev. |volume=13 |issue= 16 |pages= 2059-71 |year= 1999 |pmid= 10465784 |doi= }}
* {{cite journal | vauthors = Xu S, Cobb MH | title = MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32056–60 | date = Dec 1997 | pmid = 9405400 | doi = 10.1074/jbc.272.51.32056 }}
*{{cite journal | author=Ito M, Yoshioka K, Akechi M, ''et al.'' |title=JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7539-48 |year= 1999 |pmid= 10523642 |doi= }}
* {{cite journal | vauthors = Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR | title = 14-3-3 proteins interact with specific MEK kinases | journal = The Journal of Biological Chemistry | volume = 273 | issue = 6 | pages = 3476–83 | date = Feb 1998 | pmid = 9452471 | doi = 10.1074/jbc.273.6.3476 }}
*{{cite journal | author=Minamino T, Yujiri T, Papst PJ, ''et al.'' |title=MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 15127-32 |year= 2000 |pmid= 10611349 |doi=  }}
* {{cite journal | vauthors = Hirai S, Noda K, Moriguchi T, Nishida E, Yamashita A, Deyama T, Fukuyama K, Ohno S | title = Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 13 | pages = 7406–12 | date = Mar 1998 | pmid = 9516438 | doi = 10.1074/jbc.273.13.7406 }}
}}
* {{cite journal | vauthors = Saltzman A, Searfoss G, Marcireau C, Stone M, Ressner R, Munro R, Franks C, D'Alonzo J, Tocque B, Jaye M, Ivashchenko Y | title = hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity | journal = FEBS Letters | volume = 425 | issue = 3 | pages = 431–5 | date = Apr 1998 | pmid = 9563508 | doi = 10.1016/S0014-5793(98)00287-7 }}
* {{cite journal | vauthors = Guan Z, Buckman SY, Pentland AP, Templeton DJ, Morrison AR | title = Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 273 | issue = 21 | pages = 12901–8 | date = May 1998 | pmid = 9582321 | doi = 10.1074/jbc.273.21.12901 }}
* {{cite journal | vauthors = Lee FS, Peters RT, Dang LC, Maniatis T | title = MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 16 | pages = 9319–24 | date = Aug 1998 | pmid = 9689078 | pmc = 21336 | doi = 10.1073/pnas.95.16.9319 }}
* {{cite journal | vauthors = Yuasa T, Ohno S, Kehrl JH, Kyriakis JM | title = Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22681–92 | date = Aug 1998 | pmid = 9712898 | doi = 10.1074/jbc.273.35.22681 }}
* {{cite journal | vauthors = Pomérance M, Multon MC, Parker F, Venot C, Blondeau JP, Tocqué B, Schweighoffer F | title = Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24301–4 | date = Sep 1998 | pmid = 9733714 | doi = 10.1074/jbc.273.38.24301 }}
* {{cite journal | vauthors = Xia Y, Wu Z, Su B, Murray B, Karin M | title = JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension | journal = Genes & Development | volume = 12 | issue = 21 | pages = 3369–81 | date = Nov 1998 | pmid = 9808624 | pmc = 317229 | doi = 10.1101/gad.12.21.3369 }}
* {{cite journal | vauthors = Nemoto S, DiDonato JA, Lin A | title = Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase | journal = Molecular and Cellular Biology | volume = 18 | issue = 12 | pages = 7336–43 | date = Dec 1998 | pmid = 9819420 | pmc = 109315 | doi =  10.1128/mcb.18.12.7336}}
* {{cite journal | vauthors = Yujiri T, Sather S, Fanger GR, Johnson GL | title = Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption | journal = Science | volume = 282 | issue = 5395 | pages = 1911–4 | date = Dec 1998 | pmid = 9836645 | doi = 10.1126/science.282.5395.1911 }}
* {{cite journal | vauthors = Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M | title = Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain | journal = Genes & Development | volume = 13 | issue = 10 | pages = 1297–308 | date = May 1999 | pmid = 10346818 | pmc = 316725 | doi = 10.1101/gad.13.10.1297 }}
* {{cite journal | vauthors = Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S | title = ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway | journal = Genes & Development | volume = 13 | issue = 16 | pages = 2059–71 | date = Aug 1999 | pmid = 10465784 | pmc = 316957 | doi = 10.1101/gad.13.16.2059 }}
* {{cite journal | vauthors = Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI | title = JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7539–48 | date = Nov 1999 | pmid = 10523642 | pmc = 84763 | doi =  10.1128/mcb.19.11.7539}}
* {{cite journal | vauthors = Minamino T, Yujiri T, Papst PJ, Chan ED, Johnson GL, Terada N | title = MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 15127–32 | date = Dec 1999 | pmid = 10611349 | pmc = 24784 | doi = 10.1073/pnas.96.26.15127 }}
{{refend}}
{{refend}}


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[[Category:Mitogen-activated Protein Kinases]]
[[Category:EC 2.7.11]]

Revision as of 06:05, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.[1][2]

Function

MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin and many growth factors.[2]

Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.

Interactions

MAP3K1 has been shown to interact with:

References

  1. ↑ Vinik BS, Kay ES, Fiedorek FT (Nov 1995). "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5". Mammalian Genome. 6 (11): 782–3. doi:10.1007/BF00539003. PMID 8597633.
  2. ↑ 2.0 2.1 "Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1".
  3. ↑ Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.
  4. ↑ Zhang Y, Neo SY, Han J, Lin SC (Aug 2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase". The Journal of Biological Chemistry. 275 (32): 25008–14. doi:10.1074/jbc.M002491200. PMID 10829020.
  5. ↑ 5.0 5.1 5.2 Karandikar M, Xu S, Cobb MH (Dec 2000). "MEKK1 binds raf-1 and the ERK2 cascade components". The Journal of Biological Chemistry. 275 (51): 40120–7. doi:10.1074/jbc.M005926200. PMID 10969079.
  6. ↑ Pomérance M, Multon MC, Parker F, Venot C, Blondeau JP, Tocqué B, Schweighoffer F (Sep 1998). "Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor". The Journal of Biological Chemistry. 273 (38): 24301–4. doi:10.1074/jbc.273.38.24301. PMID 9733714.
  7. ↑ Xu S, Cobb MH (Dec 1997). "MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases". The Journal of Biological Chemistry. 272 (51): 32056–60. doi:10.1074/jbc.272.51.32056. PMID 9405400.
  8. ↑ Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M (May 1999). "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain". Genes & Development. 13 (10): 1297–308. doi:10.1101/gad.13.10.1297. PMC 316725. PMID 10346818.
  9. ↑ Saltzman A, Searfoss G, Marcireau C, Stone M, Ressner R, Munro R, Franks C, D'Alonzo J, Tocque B, Jaye M, Ivashchenko Y (Apr 1998). "hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity". FEBS Letters. 425 (3): 431–5. doi:10.1016/s0014-5793(98)00287-7. PMID 9563508.

Further reading

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