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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''MAP kinase-activated protein kinase 2''' is an [[enzyme]] that in humans is encoded by the ''MAPKAPK2'' [[gene]].<ref name="pmid8179591">{{cite journal | vauthors = Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK | title = The primary structure of a human MAP kinase activated protein kinase 2 | journal = Biochem Biophys Res Commun | volume = 200 | issue = 2 | pages = 1118–24 | date = Jun 1994 | pmid = 8179591 | pmc =  | doi = 10.1006/bbrc.1994.1566 }}</ref><ref name="pmid8280084">{{cite journal | vauthors = Stokoe D, Caudwell B, Cohen PT, Cohen P | title = The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2 | journal = Biochem J | volume = 296 | issue = Pt 3 | pages = 843–9 | date = Feb 1994 | pmid = 8280084 | pmc = 1137771 | doi = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAPKAPK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kwp.
| PDB = {{PDB2|1kwp}}, {{PDB2|1nxk}}, {{PDB2|1ny3}}, {{PDB2|2jbo}}, {{PDB2|2jbp}}, {{PDB2|2onl}}, {{PDB2|2oza}}
| Name = Mitogen-activated protein kinase-activated protein kinase 2
| HGNCid = 6887
| Symbol = MAPKAPK2
| AltSymbols =;
| OMIM = 602006
| ECnumber = 
| Homologene = 56412
| MGIid = 109298
| GeneAtlas_image1 = PBB_GE_MAPKAPK2_201460_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAPKAPK2_201461_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MAPKAPK2_215050_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0048255 |text = mRNA stabilization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9261
    | Hs_Ensembl = ENSG00000162889
    | Hs_RefseqProtein = NP_004750
    | Hs_RefseqmRNA = NM_004759
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 204924912
    | Hs_GenLoc_end = 204974251
    | Hs_Uniprot = P49137
    | Mm_EntrezGene = 17164
    | Mm_Ensembl = ENSMUSG00000016528
    | Mm_RefseqmRNA = XM_977114
    | Mm_RefseqProtein = XP_982208
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 132881250
    | Mm_GenLoc_end = 132925113
    | Mm_Uniprot = Q3U2P8
  }}
}}
'''Mitogen-activated protein kinase-activated protein kinase 2''', also known as '''MAPKAPK2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by [[p38 MAP kinase]]. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9261| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9261| accessdate = }}</ref>
}}


==References==
== See also ==
{{reflist|2}}
* [[SB 203580]], suppresses the activation of MAPKAPK2
==Further reading==
 
== Interactions ==
 
MAPKAPK2 has been shown to [[Protein-protein interaction|interact]] with:
* [[AKT1]],<ref name = pmid11042204/>
* [[MAPK14]],<ref name = pmid11042204>{{cite journal | vauthors = Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR | title = p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils | journal = J. Biol. Chem. | volume = 276 | issue = 5 | pages = 3517–23 | date = Feb 2001 | pmid = 11042204 | doi = 10.1074/jbc.M005953200 }}</ref><ref name = pmid11551945>{{cite journal | vauthors = Janknecht R | title = Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2 | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 41856–61 | date = Nov 2001 | pmid = 11551945 | doi = 10.1074/jbc.M106630200 }}</ref>
* [[PHC2]],<ref name = pmid15094067>{{cite journal | vauthors = Yannoni YM, Gaestel M, Lin LL | title = P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity | journal = FEBS Lett. | volume = 564 | issue = 1-2 | pages = 205–11 | date = Apr 2004 | pmid = 15094067 | doi = 10.1016/S0014-5793(04)00351-5 }}</ref>  and
* [[SHC1]].<ref name = pmid15094067/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, Wollert KC, Schieffer B, Gaestel M, Bauersachs J, Bavendiek U |author-link10=Johann Bauersachs | title = Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury | journal = Thromb Haemost. | volume = 112 | issue = 6 | pages = 1–13 | year = 2014 | pmid = 25120198 | doi = 10.1160/TH14-02-0174 }}
| citations =
* {{cite journal | vauthors = Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ | title = Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2 | journal = Curr. Biol. | volume = 8 | issue = 19 | pages = 1049–57 | year = 1999 | pmid = 9768359 | doi = 10.1016/S0960-9822(98)70442-7 }}
*{{cite journal | author=Ben-Levy R, Hooper S, Wilson R, ''et al.'' |title=Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. |journal=Curr. Biol. |volume=8 |issue= 19 |pages= 1049-57 |year= 1999 |pmid= 9768359 |doi= }}
* {{cite journal | vauthors = Stokoe D, Engel K, Campbell DG, Cohen P, Gaestel M | title = Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins | journal = FEBS Lett. | volume = 313 | issue = 3 | pages = 307–13 | year = 1992 | pmid = 1332886 | doi = 10.1016/0014-5793(92)81216-9 }}
*{{cite journal | author=Stokoe D, Engel K, Campbell DG, ''et al.'' |title=Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. |journal=FEBS Lett. |volume=313 |issue= 3 |pages= 307-13 |year= 1992 |pmid= 1332886 |doi= }}
* {{cite journal | vauthors = Vulliet PR, Woodgett JR, Cohen P | title = Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase | journal = J. Biol. Chem. | volume = 259 | issue = 22 | pages = 13680–3 | year = 1984 | pmid = 6150037 | doi =  }}
*{{cite journal | author=Vulliet PR, Woodgett JR, Cohen P |title=Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. |journal=J. Biol. Chem. |volume=259 |issue= 22 |pages= 13680-3 |year= 1984 |pmid= 6150037 |doi= }}
* {{cite journal | vauthors = Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M | title = Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif | journal = J. Biol. Chem. | volume = 270 | issue = 45 | pages = 27213–21 | year = 1995 | pmid = 7592979 | doi = 10.1074/jbc.270.45.27213 }}
*{{cite journal | author=Engel K, Schultz H, Martin F, ''et al.'' |title=Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 27213-21 |year= 1995 |pmid= 7592979 |doi=  }}
* {{cite journal | vauthors = Lavoie JN, Lambert H, Hickey E, Weber LA, Landry J | title = Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27 | journal = Mol. Cell. Biol. | volume = 15 | issue = 1 | pages = 505–16 | year = 1995 | pmid = 7799959 | pmc = 232001 | doi =  }}
*{{cite journal | author=Lavoie JN, Lambert H, Hickey E, ''et al.'' |title=Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 505-16 |year= 1995 |pmid= 7799959 |doi= }}
* {{cite journal | vauthors = Sutherland C, Alterio J, Campbell DG, Le Bourdellès B, Mallet J, Haavik J, Cohen P | title = Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2 | journal = Eur. J. Biochem. | volume = 217 | issue = 2 | pages = 715–22 | year = 1993 | pmid = 7901013 | doi = 10.1111/j.1432-1033.1993.tb18297.x }}
*{{cite journal | author=Sutherland C, Alterio J, Campbell DG, ''et al.'' |title=Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. |journal=Eur. J. Biochem. |volume=217 |issue= 2 |pages= 715-22 |year= 1993 |pmid= 7901013 |doi=  }}
* {{cite journal | vauthors = Knauf U, Jakob U, Engel K, Buchner J, Gaestel M | title = Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance | journal = EMBO J. | volume = 13 | issue = 1 | pages = 54–60 | year = 1994 | pmid = 7905823 | pmc = 394778 | doi =  }}
*{{cite journal | author=Knauf U, Jakob U, Engel K, ''et al.'' |title=Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance. |journal=EMBO J. |volume=13 |issue= 1 |pages= 54-60 |year= 1994 |pmid= 7905823 |doi= }}
* {{cite journal | vauthors = Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J | title = Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27 | journal = Cell | volume = 78 | issue = 6 | pages = 1039–49 | year = 1994 | pmid = 7923354 | doi = 10.1016/0092-8674(94)90278-X }}
*{{cite journal | author=Freshney NW, Rawlinson L, Guesdon F, ''et al.'' |title=Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. |journal=Cell |volume=78 |issue= 6 |pages= 1039-49 |year= 1994 |pmid= 7923354 |doi=  }}
* {{cite journal | vauthors = Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME | title = A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity | journal = Mol. Cell. Biol. | volume = 13 | issue = 10 | pages = 6260–73 | year = 1993 | pmid = 8413226 | pmc = 364685 | doi =  10.1128/mcb.13.10.6260}}
*{{cite journal | author=Zu YL, Wu F, Gilchrist A, ''et al.'' |title=The primary structure of a human MAP kinase activated protein kinase 2. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 2 |pages= 1118-24 |year= 1994 |pmid= 8179591 |doi= }}
* {{cite journal | vauthors = Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W | title = The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor | journal = EMBO J. | volume = 15 | issue = 8 | pages = 1914–23 | year = 1996 | pmid = 8617238 | pmc = 450110 | doi =  }}
*{{cite journal | author=Stokoe D, Caudwell B, Cohen PT, Cohen P |title=The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. |journal=Biochem. J. |volume=296 ( Pt 3) |issue= |pages= 843-9 |year= 1994 |pmid= 8280084 |doi=  }}
* {{cite journal | vauthors = Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P | title = Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2 | journal = EMBO J. | volume = 14 | issue = 23 | pages = 5920–30 | year = 1996 | pmid = 8846784 | pmc = 394711 | doi =  }}
*{{cite journal | author=Rivera VM, Miranti CK, Misra RP, ''et al.'' |title=A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6260-73 |year= 1993 |pmid= 8413226 |doi=  }}
* {{cite journal | vauthors = Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ | title = FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 | journal = EMBO J. | volume = 15 | issue = 17 | pages = 4629–42 | year = 1997 | pmid = 8887554 | pmc = 452194 | doi =  }}
*{{cite journal | author=Beyaert R, Cuenda A, Vanden Berghe W, ''et al.'' |title=The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. |journal=EMBO J. |volume=15 |issue= 8 |pages= 1914-23 |year= 1996 |pmid= 8617238 |doi=  }}
* {{cite journal | vauthors = Huang CK, Zhan L, Ai Y, Jongstra J | title = LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils | journal = J. Biol. Chem. | volume = 272 | issue = 1 | pages = 17–9 | year = 1997 | pmid = 8995217 | doi = 10.1074/jbc.272.1.17 }}
*{{cite journal | author=Ben-Levy R, Leighton IA, Doza YN, ''et al.'' |title=Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. |journal=EMBO J. |volume=14 |issue= 23 |pages= 5920-30 |year= 1996 |pmid= 8846784 |doi=  }}
* {{cite journal | vauthors = Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S | title = Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 937–44 | year = 1997 | pmid = 8995385 | doi = 10.1074/jbc.272.2.937 }}
*{{cite journal | author=Tan Y, Rouse J, Zhang A, ''et al.'' |title=FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. |journal=EMBO J. |volume=15 |issue= 17 |pages= 4629-42 |year= 1997 |pmid= 8887554 |doi= }}
* {{cite journal | vauthors = Engel K, Kotlyarov A, Gaestel M | title = Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation | journal = EMBO J. | volume = 17 | issue = 12 | pages = 3363–71 | year = 1998 | pmid = 9628873 | pmc = 1170674 | doi = 10.1093/emboj/17.12.3363 }}
*{{cite journal | author=Huang CK, Zhan L, Ai Y, Jongstra J |title=LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils. |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 17-9 |year= 1997 |pmid= 8995217 |doi= }}
* {{cite journal | vauthors = Craxton A, Shu G, Graves JD, Saklatvala J, Krebs EG, Clark EA | title = p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes | journal = J. Immunol. | volume = 161 | issue = 7 | pages = 3225–36 | year = 1998 | pmid = 9759836 | doi = }}
*{{cite journal | author=Krump E, Sanghera JS, Pelech SL, ''et al.'' |title=Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 937-44 |year= 1997 |pmid= 8995385 |doi= }}
* {{cite journal | vauthors = Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A | title = MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 20 | pages = 14434–43 | year = 1999 | pmid = 10318869 | doi = 10.1074/jbc.274.20.14434 }}
*{{cite journal | author=Engel K, Kotlyarov A, Gaestel M |title=Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3363-71 |year= 1998 |pmid= 9628873 |doi= 10.1093/emboj/17.12.3363 }}
*{{cite journal | author=Craxton A, Shu G, Graves JD, ''et al.'' |title=p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. |journal=J. Immunol. |volume=161 |issue= 7 |pages= 3225-36 |year= 1998 |pmid= 9759836 |doi= }}
*{{cite journal  | author=Heidenreich O, Neininger A, Schratt G, ''et al.'' |title=MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14434-43 |year= 1999 |pmid= 10318869 |doi=  }}
}}
{{refend}}
{{refend}}


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Revision as of 06:08, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.[1][2]

Function

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.[3]

See also

  • SB 203580, suppresses the activation of MAPKAPK2

Interactions

MAPKAPK2 has been shown to interact with:

References

  1. ↑ Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (Jun 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochem Biophys Res Commun. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591.
  2. ↑ Stokoe D, Caudwell B, Cohen PT, Cohen P (Feb 1994). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". Biochem J. 296 (Pt 3): 843–9. PMC 1137771. PMID 8280084.
  3. ↑ "Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2".
  4. ↑ 4.0 4.1 Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR (Feb 2001). "p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils". J. Biol. Chem. 276 (5): 3517–23. doi:10.1074/jbc.M005953200. PMID 11042204.
  5. ↑ Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". J. Biol. Chem. 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945.
  6. ↑ 6.0 6.1 Yannoni YM, Gaestel M, Lin LL (Apr 2004). "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Lett. 564 (1–2): 205–11. doi:10.1016/S0014-5793(04)00351-5. PMID 15094067.

Further reading


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