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{{Infobox_gene}}
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'''28S ribosomal protein S12, mitochondrial''' is a [[protein]] that in humans is encoded by the ''MRPS12'' [[gene]].<ref name="pmid9545647">{{cite journal |vauthors=Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT | title = Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus | journal = Genomics | volume = 48 | issue = 3 | pages = 384–8 |date=Jun 1998 | pmid = 9545647 | pmc =  | doi = 10.1006/geno.1997.5166 }}</ref><ref name="pmid9790755">{{cite journal |vauthors=Johnson DF, Hamon M, Fischel-Ghodsian N | title = Characterization of the human mitochondrial ribosomal S12 gene | journal = Genomics | volume = 52 | issue = 3 | pages = 363–8 |date=Dec 1998 | pmid = 9790755 | pmc =  | doi = 10.1006/geno.1998.5448 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRPS12 mitochondrial ribosomal protein S12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6183| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Mitochondrial ribosomal protein S12
| HGNCid = 10380
| Symbol = MRPS12
| AltSymbols =; MPR-S12; MT-RPS12; RPMS12; RPS12; RPSM12
| OMIM = 603021
| ECnumber =
  | Homologene = 6848
| MGIid = 1346333
| GeneAtlas_image1 = PBB_GE_MRPS12_204331_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003735 |text = structural constituent of ribosome}}  
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005761 |text = mitochondrial ribosome}} {{GNF_GO|id=GO:0015935 |text = small ribosomal subunit}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6183
    | Hs_Ensembl = ENSG00000128626
    | Hs_RefseqProtein = NP_066930
    | Hs_RefseqmRNA = NM_021107
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 44113028
    | Hs_GenLoc_end = 44115493
    | Hs_Uniprot = O15235
    | Mm_EntrezGene = 24030
    | Mm_Ensembl = ENSMUSG00000045948
    | Mm_RefseqmRNA = NM_011885
    | Mm_RefseqProtein = NP_036015
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 28448401
    | Mm_GenLoc_end = 28450550
    | Mm_Uniprot = O35680
  }}
}}
'''Mitochondrial ribosomal protein S12''', also known as '''MRPS12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MRPS12 mitochondrial ribosomal protein S12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6183| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: MRPS12 mitochondrial ribosomal protein S12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6183| accessdate = }}</ref>
| summary_text = Mammalian [[Mitochondrial ribosome|mitochondrial ribosomal]] proteins are encoded by [[nuclear gene]]s and help in [[protein synthesis]] within the [[mitochondrion]]. Mitochondrial ribosomes (mitoribosomes) consist of a small [[28S ribosomal RNA|28S]] subunit and a large 39S subunit. They have an estimated 75% [[protein]] to [[rRNA]] composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a [[5S rRNA]]. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by [[sequence homology]]. This gene encodes a 28S subunit protein that belongs to the [[ribosomal protein]] S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to [[aminoglycoside antibiotic]]s. The gene for mitochondrial [[Serine|seryl]]-[[Aminoacyl tRNA synthetase|tRNA synthetase]] is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). [[Alternative splicing|Splice variants]] that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Shah ZH, O'Dell KM, Miller SC, ''et al.'' |title=Metazoan nuclear genes for mitoribosomal protein S12. |journal=Gene |volume=204 |issue= 1-2 |pages= 55-62 |year= 1998 |pmid= 9434165 |doi= }}
*{{cite journal   |vauthors=Shah ZH, O'Dell KM, Miller SC, etal |title=Metazoan nuclear genes for mitoribosomal protein S12. |journal=Gene |volume=204 |issue= 1-2 |pages= 55–62 |year= 1998 |pmid= 9434165 |doi=10.1016/S0378-1119(97)00521-0 }}
*{{cite journal  | author=Shah ZH, Migliosi V, Miller SC, ''et al.'' |title=Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. |journal=Genomics |volume=48 |issue= 3 |pages= 384-8 |year= 1998 |pmid= 9545647 |doi= 10.1006/geno.1997.5166 }}
*{{cite journal   |vauthors=Mariottini P, Shah ZH, Toivonen JM, etal |title=Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 31853–62 |year= 1999 |pmid= 10542210 |doi=10.1074/jbc.274.45.31853 }}
*{{cite journal | author=Johnson DF, Hamon M, Fischel-Ghodsian N |title=Characterization of the human mitochondrial ribosomal S12 gene. |journal=Genomics |volume=52 |issue= 3 |pages= 363-8 |year= 1998 |pmid= 9790755 |doi= 10.1006/geno.1998.5448 }}
*{{cite journal   |vauthors=Cavdar Koc E, Burkhart W, Blackburn K, etal |title=The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19363–74 |year= 2001 |pmid= 11279123 |doi= 10.1074/jbc.M100727200 }}
*{{cite journal | author=Mariottini P, Shah ZH, Toivonen JM, ''et al.'' |title=Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 31853-62 |year= 1999 |pmid= 10542210 |doi=  }}
*{{cite journal   |vauthors=Suzuki T, Terasaki M, Takemoto-Hori C, etal |title=Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33181–95 |year= 2001 |pmid= 11402041 |doi= 10.1074/jbc.M103236200 }}
*{{cite journal | author=Cavdar Koc E, Burkhart W, Blackburn K, ''et al.'' |title=The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19363-74 |year= 2001 |pmid= 11279123 |doi= 10.1074/jbc.M100727200 }}
*{{cite journal   |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal | author=Suzuki T, Terasaki M, Takemoto-Hori C, ''et al.'' |title=Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33181-95 |year= 2001 |pmid= 11402041 |doi= 10.1074/jbc.M103236200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kenmochi N, Suzuki T, Uechi T, ''et al.'' |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65-70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal  |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Cui YP, Wang JB, Zhang XY, etal |title=Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. |journal=World J. Gastroenterol. |volume=9 |issue= 9 |pages= 1892–6 |year= 2003 |pmid= 12970870 |doi=  }}
*{{cite journal  | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468-80 |year= 2003 |pmid= 12706105 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Cui YP, Wang JB, Zhang XY, ''et al.'' |title=Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. |journal=World J. Gastroenterol. |volume=9 |issue= 9 |pages= 1892-6 |year= 2003 |pmid= 12970870 |doi=  }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
}}
{{refend}}
{{refend}}


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{{GeneticTranslation}}
{{Ribosome subunits}}
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[[Category:Ribosomal proteins]]

Revision as of 06:51, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
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28S ribosomal protein S12, mitochondrial is a protein that in humans is encoded by the MRPS12 gene.[1][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.[3]

References

  1. ↑ Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT (Jun 1998). "Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus". Genomics. 48 (3): 384–8. doi:10.1006/geno.1997.5166. PMID 9545647.
  2. ↑ Johnson DF, Hamon M, Fischel-Ghodsian N (Dec 1998). "Characterization of the human mitochondrial ribosomal S12 gene". Genomics. 52 (3): 363–8. doi:10.1006/geno.1998.5448. PMID 9790755.
  3. ↑ 3.0 3.1 "Entrez Gene: MRPS12 mitochondrial ribosomal protein S12".

Further reading


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