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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{For|mammalian sterile 20–like kinase-1|STK4}}
{{PBB_Controls
{{Distinguish|Macrophage colony-stimulating factor}}
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{{Infobox_gene}}
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'''Macrophage-stimulating protein''' ('''MSP'''), also known as '''hepatocyte growth factor-like protein''' ('''HLP''', '''HGFL''', or '''HGFLP'''), is a [[protein]] that in humans is encoded by the ''MST1'' (''macrophage-stimulating 1'') [[gene]].<ref name="pmid2902784">{{cite journal |vauthors=Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI | title = Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel | journal = Am J Hum Genet | volume = 43 | issue = 4 | pages = 442–51 |date=Oct 1988 | pmid = 2902784 | pmc = 1715492 | doi = }}</ref><ref name="pmid8393443">{{cite journal |vauthors=Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ | title = Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3 | journal = J Biol Chem | volume = 268 | issue = 21 | pages = 15461–8 |date=Aug 1993 | pmid = 8393443 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4485| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MST1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2asu.
| PDB = {{PDB2|2asu}}
| Name = Macrophage stimulating 1 (hepatocyte growth factor-like)
| HGNCid = 7380
| Symbol = MST1
| AltSymbols =; D3F15S2; DNF15S2; MSP; HGFL; NF15S2
| OMIM = 142408
| ECnumber = 
| Homologene = 7360
| MGIid = 96080
| GeneAtlas_image1 = PBB_GE_MST1_205614_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_MST1_213380_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_MST1_216320_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4485
    | Hs_Ensembl = ENSG00000173531
    | Hs_RefseqProtein = NP_066278
    | Hs_RefseqmRNA = NM_020998
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 49696393
    | Hs_GenLoc_end = 49701099
    | Hs_Uniprot = P26927
    | Mm_EntrezGene = 15235
    | Mm_Ensembl = ENSMUSG00000032591
    | Mm_RefseqmRNA = NM_008243
    | Mm_RefseqProtein = NP_032269
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 107938553
    | Mm_GenLoc_end = 107943101
    | Mm_Uniprot = Q3UZ05
  }}
}}
'''Macrophage stimulating 1 (hepatocyte growth factor-like)''', also known as '''MST1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4485| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Han S, Stuart LA, Degen SJ |title=Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. |journal=Biochemistry |volume=30 |issue= 40 |pages= 9768-80 |year= 1991 |pmid= 1655021 |doi=  }}
*{{cite journal  |vauthors=Han S, Stuart LA, Degen SJ |title=Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. |journal=Biochemistry |volume=30 |issue= 40 |pages= 9768–80 |year= 1991 |pmid= 1655021 |doi=10.1021/bi00104a029 }}
*{{cite journal | author=Skeel A, Yoshimura T, Showalter SD, ''et al.'' |title=Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. |journal=J. Exp. Med. |volume=173 |issue= 5 |pages= 1227-34 |year= 1991 |pmid= 1827141 |doi=  }}
*{{cite journal   |vauthors=Skeel A, Yoshimura T, Showalter SD, etal |title=Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. |journal=J. Exp. Med. |volume=173 |issue= 5 |pages= 1227–34 |year= 1991 |pmid= 1827141 |doi=10.1084/jem.173.5.1227  | pmc=2118857 }}
*{{cite journal  | author=Gerber MJ, Drabkin HA, Firnhaber C, ''et al.'' |title=Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. |journal=Am. J. Hum. Genet. |volume=43 |issue= 4 |pages= 442-51 |year= 1988 |pmid= 2902784 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal   |vauthors=Waltz SE, Gould FK, Air EL, etal |title=Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 9024–32 |year= 1996 |pmid= 8621550 |doi=10.1074/jbc.271.15.9024  }}
*{{cite journal  | author=Yoshimura T, Yuhki N, Wang MH, ''et al.'' |title=Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. |journal=J. Biol. Chem. |volume=268 |issue= 21 |pages= 15461-8 |year= 1993 |pmid= 8393443 |doi=  }}
*{{cite journal  |vauthors=Creasy CL, Ambrose DM, Chernoff J |title=The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21049–53 |year= 1996 |pmid= 8702870 |doi=10.1074/jbc.271.35.21049 }}
*{{cite journal | author=Waltz SE, Gould FK, Air EL, ''et al.'' |title=Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 9024-32 |year= 1996 |pmid= 8621550 |doi=  }}
*{{cite journal   |vauthors=Sakamoto O, Iwama A, Amitani R, etal |title=Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility |journal=J. Clin. Invest. |volume=99 |issue= 4 |pages= 701–9 |year= 1997 |pmid= 9045873 |doi=10.1172/JCI119214  | pmc=507853 }}
*{{cite journal | author=Creasy CL, Ambrose DM, Chernoff J |title=The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21049-53 |year= 1996 |pmid= 8702870 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal | author=Sakamoto O, Iwama A, Amitani R, ''et al.'' |title=Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. |journal=J. Clin. Invest. |volume=99 |issue= 4 |pages= 701-9 |year= 1997 |pmid= 9045873 |doi= }}
*{{cite journal   |vauthors=Yoshikawa W, Hara H, Takehara T, etal |title=Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein |journal=Arch. Biochem. Biophys. |volume=363 |issue= 2 |pages= 356–60 |year= 1999 |pmid= 10068459 |doi= 10.1006/abbi.1998.1090 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Degen SJ, McDowell SA, Waltz SE, etal |title=Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein |journal=DNA Seq. |volume=8 |issue= 6 |pages= 409–13 |year= 2000 |pmid= 10728827 |doi=10.3109/10425179809020903 }}
*{{cite journal  | author=Yoshikawa W, Hara H, Takehara T, ''et al.'' |title=Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein. |journal=Arch. Biochem. Biophys. |volume=363 |issue= 2 |pages= 356-60 |year= 1999 |pmid= 10068459 |doi= 10.1006/abbi.1998.1090 }}
*{{cite journal  |vauthors=Skeel A, Leonard EJ |title=alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21932–7 |year= 2001 |pmid= 11274154 |doi= 10.1074/jbc.M100652200 }}
*{{cite journal | author=Degen SJ, McDowell SA, Waltz SE, ''et al.'' |title=Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein. |journal=DNA Seq. |volume=8 |issue= 6 |pages= 409-13 |year= 2000 |pmid= 10728827 |doi=  }}
*{{cite journal   |vauthors=Rampino T, Collesi C, Gregorini M, etal |title=Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 3 |pages= 649–57 |year= 2002 |pmid= 11856768 |doi=  }}
*{{cite journal  | author=Skeel A, Leonard EJ |title=alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21932-7 |year= 2001 |pmid= 11274154 |doi= 10.1074/jbc.M100652200 }}
*{{cite journal  |vauthors=Zhou YQ, Chen YQ, Fisher JH, Wang MH |title=Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38104–10 |year= 2002 |pmid= 12177064 |doi= 10.1074/jbc.M206167200 }}
*{{cite journal | author=Rampino T, Collesi C, Gregorini M, ''et al.'' |title=Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 3 |pages= 649-57 |year= 2002 |pmid= 11856768 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Zhou YQ, Chen YQ, Fisher JH, Wang MH |title=Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38104-10 |year= 2002 |pmid= 12177064 |doi= 10.1074/jbc.M206167200 }}
*{{cite journal  |vauthors=Santoro MM, Gaudino G, Marchisio PC |title=The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration |journal=Dev. Cell |volume=5 |issue= 2 |pages= 257–71 |year= 2003 |pmid= 12919677 |doi=10.1016/S1534-5807(03)00201-6  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Angeloni D, Danilkovitch-Miagkova A, Miagkov A, etal |title=The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3726–32 |year= 2004 |pmid= 14597639 |doi= 10.1074/jbc.M309342200 }}
*{{cite journal | author=Santoro MM, Gaudino G, Marchisio PC |title=The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. |journal=Dev. Cell |volume=5 |issue= 2 |pages= 257-71 |year= 2003 |pmid= 12919677 |doi= }}
*{{cite journal   |vauthors=Matsuzaki S, Canis M, Pouly JL, etal |title=The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis |journal=Mol. Hum. Reprod. |volume=11 |issue= 5 |pages= 345–9 |year= 2005 |pmid= 15764806 |doi= 10.1093/molehr/gah162 }}
*{{cite journal | author=Angeloni D, Danilkovitch-Miagkova A, Miagkov A, ''et al.'' |title=The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3726-32 |year= 2004 |pmid= 14597639 |doi= 10.1074/jbc.M309342200 }}
*{{cite journal   |vauthors=Zalcenstein A, Weisz L, Stambolsky P, etal |title=Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53 |journal=Oncogene |volume=25 |issue= 3 |pages= 359–69 |year= 2006 |pmid= 16170349 |doi= 10.1038/sj.onc.1209061 }}
*{{cite journal | author=Matsuzaki S, Canis M, Pouly JL, ''et al.'' |title=The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis. |journal=Mol. Hum. Reprod. |volume=11 |issue= 5 |pages= 345-9 |year= 2005 |pmid= 15764806 |doi= 10.1093/molehr/gah162 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Zalcenstein A, Weisz L, Stambolsky P, ''et al.'' |title=Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53. |journal=Oncogene |volume=25 |issue= 3 |pages= 359-69 |year= 2006 |pmid= 16170349 |doi= 10.1038/sj.onc.1209061 }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4485}}
{{Growth factors}}
{{Cytokines}}
{{Growth factor receptor modulators}}
{{Cytokine receptor modulators}}
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{{protein-stub}}
{{gene-3-stub}}
{{WikiDoc Sources}}

Latest revision as of 06:57, 4 September 2017

For mammalian sterile 20–like kinase-1, see STK4.
Not to be confused with Macrophage colony-stimulating factor.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene.[1][2][3]


References

  1. ↑ Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (Oct 1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel". Am J Hum Genet. 43 (4): 442–51. PMC 1715492. PMID 2902784.
  2. ↑ Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ (Aug 1993). "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3". J Biol Chem. 268 (21): 15461–8. PMID 8393443.
  3. ↑ "Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)".

Further reading



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