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{{Underlinked|date=November 2017}}
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{{Infobox_gene}}
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'''Myosin-Ic''' is a [[protein]] that in humans is encoded by the ''MYO1C'' [[gene]].<ref name="pmid9119401">{{cite journal |vauthors=Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C | title = Cloning of the genes encoding two murine and human cochlear unconventional type I myosins | journal = Genomics | volume = 40 | issue = 2 | pages = 332–41 |date=Apr 1997 | pmid = 9119401 | pmc =  | doi =10.1006/geno.1996.4526 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYO1C myosin IC| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4641| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myosin IC
| HGNCid = 7597
| Symbol = MYO1C
| AltSymbols =; FLJ23903; MMI-beta; MMIb; NMI; myr2
| OMIM = 606538
| ECnumber =
| Homologene = 32046
  | MGIid = 106612
| GeneAtlas_image1 = PBB_GE_MYO1C_214656_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYO1C_32811_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005902 |text = microvillus}} {{GNF_GO|id=GO:0005903 |text = brush border}} {{GNF_GO|id=GO:0009925 |text = basal plasma membrane}} {{GNF_GO|id=GO:0016328 |text = lateral plasma membrane}} {{GNF_GO|id=GO:0016459 |text = myosin complex}} {{GNF_GO|id=GO:0031941 |text = filamentous actin}} {{GNF_GO|id=GO:0045160 |text = myosin I complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4641
    | Hs_Ensembl = ENSG00000197879
    | Hs_RefseqProtein = NP_001074248
    | Hs_RefseqmRNA = NM_001080779
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 1314230
    | Hs_GenLoc_end = 1342745
    | Hs_Uniprot = O00159
    | Mm_EntrezGene = 17913
    | Mm_Ensembl = ENSMUSG00000017774
    | Mm_RefseqmRNA = XM_622553
    | Mm_RefseqProtein = XP_622553
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 75467705
    | Mm_GenLoc_end = 75491308
    | Mm_Uniprot = Q3TBQ4
  }}
}}
'''Myosin IC''', also known as '''MYO1C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYO1C myosin IC| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4641| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.<ref name="entrez">{{cite web | title = Entrez Gene: MYO1C myosin IC| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4641| accessdate = }}</ref>
| summary_text = This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.<ref name="entrez">{{cite web | title = Entrez Gene: MYO1C myosin IC| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4641| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Ruppert C, Godel J, Müller RT, ''et al.'' |title=Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains. |journal=J. Cell. Sci. |volume=108 ( Pt 12) |issue=  |pages= 3775-86 |year= 1997 |pmid= 8719884 |doi=  }}
*{{cite journal   |vauthors=Ruppert C, Godel J, Müller RT, etal |title=Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains. |journal=J. Cell Sci. |volume=108 |issue=  12|pages= 3775–86 |year= 1997 |pmid= 8719884 |doi=  }}
*{{cite journal | author=Hasson T, Skowron JF, Gilbert DJ, ''et al.'' |title=Mapping of unconventional myosins in mouse and human. |journal=Genomics |volume=36 |issue= 3 |pages= 431-9 |year= 1997 |pmid= 8884266 |doi= 10.1006/geno.1996.0488 }}
*{{cite journal   |vauthors=Hasson T, Skowron JF, Gilbert DJ, etal |title=Mapping of unconventional myosins in mouse and human. |journal=Genomics |volume=36 |issue= 3 |pages= 431–9 |year= 1997 |pmid= 8884266 |doi= 10.1006/geno.1996.0488 }}
*{{cite journal  | author=Crozet F, el Amraoui A, Blanchard S, ''et al.'' |title=Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. |journal=Genomics |volume=40 |issue= 2 |pages= 332-41 |year= 1997 |pmid= 9119401 |doi=  }}
*{{cite journal  |vauthors=Skowron JF, Bement WM, Mooseker MS |title=Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. |journal=Cell Motil. Cytoskeleton |volume=41 |issue= 4 |pages= 308–24 |year= 1999 |pmid= 9858156 |doi= 10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J }}
*{{cite journal  | author=Skowron JF, Bement WM, Mooseker MS |title=Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. |journal=Cell Motil. Cytoskeleton |volume=41 |issue= 4 |pages= 308-24 |year= 1999 |pmid= 9858156 |doi= 10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J }}
*{{cite journal   |vauthors=Pestic-Dragovich L, Stojiljkovic L, Philimonenko AA, etal |title=A myosin I isoform in the nucleus. |journal=Science |volume=290 |issue= 5490 |pages= 337–41 |year= 2000 |pmid= 11030652 |doi=10.1126/science.290.5490.337 }}
*{{cite journal | author=Pestic-Dragovich L, Stojiljkovic L, Philimonenko AA, ''et al.'' |title=A myosin I isoform in the nucleus. |journal=Science |volume=290 |issue= 5490 |pages= 337-41 |year= 2000 |pmid= 11030652 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal   |vauthors=Philimonenko VV, Zhao J, Iben S, etal |title=Nuclear actin and myosin I are required for RNA polymerase I transcription. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1165–72 |year= 2005 |pmid= 15558034 |doi= 10.1038/ncb1190 }}
*{{cite journal | author=Philimonenko VV, Zhao J, Iben S, ''et al.'' |title=Nuclear actin and myosin I are required for RNA polymerase I transcription. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1165-72 |year= 2005 |pmid= 15558034 |doi= 10.1038/ncb1190 }}
*{{cite journal   |vauthors=Kyselá K, Philimonenko AA, Philimonenko VV, etal |title=Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell. |journal=Histochem. Cell Biol. |volume=124 |issue= 5 |pages= 347–58 |year= 2005 |pmid= 16133118 |doi= 10.1007/s00418-005-0042-8 }}
*{{cite journal | author=Kyselá K, Philimonenko AA, Philimonenko VV, ''et al.'' |title=Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell. |journal=Histochem. Cell Biol. |volume=124 |issue= 5 |pages= 347-58 |year= 2005 |pmid= 16133118 |doi= 10.1007/s00418-005-0042-8 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  |vauthors=Cavellán E, Asp P, Percipalle P, Farrants AK |title=The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16264–71 |year= 2006 |pmid= 16603771 |doi= 10.1074/jbc.M600233200 }}
*{{cite journal  | author=Cavellán E, Asp P, Percipalle P, Farrants AK |title=The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16264-71 |year= 2006 |pmid= 16603771 |doi= 10.1074/jbc.M600233200 }}
*{{cite journal  |vauthors=Cisterna B, Necchi D, Prosperi E, Biggiogera M |title=Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores. |journal=FASEB J. |volume=20 |issue= 11 |pages= 1901–3 |year= 2006 |pmid= 16877530 |doi= 10.1096/fj.05-5278fje }}
*{{cite journal  | author=Cisterna B, Necchi D, Prosperi E, Biggiogera M |title=Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores. |journal=FASEB J. |volume=20 |issue= 11 |pages= 1901-3 |year= 2006 |pmid= 16877530 |doi= 10.1096/fj.05-5278fje }}
*{{cite journal   |vauthors=Kahle M, Pridalová J, Spacek M, etal |title=Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates. |journal=Histochem. Cell Biol. |volume=127 |issue= 2 |pages= 139–48 |year= 2007 |pmid= 16957816 |doi= 10.1007/s00418-006-0231-0 }}
*{{cite journal | author=Kahle M, Pridalová J, Spacek M, ''et al.'' |title=Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates. |journal=Histochem. Cell Biol. |volume=127 |issue= 2 |pages= 139-48 |year= 2007 |pmid= 16957816 |doi= 10.1007/s00418-006-0231-0 }}
*{{cite journal   |vauthors=Hofmann WA, Vargas GM, Ramchandran R, etal |title=Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II. |journal=J. Cell. Biochem. |volume=99 |issue= 4 |pages= 1001–9 |year= 2006 |pmid= 16960872 |doi= 10.1002/jcb.21035 }}
*{{cite journal | author=Hofmann WA, Vargas GM, Ramchandran R, ''et al.'' |title=Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II. |journal=J. Cell. Biochem. |volume=99 |issue= 4 |pages= 1001-9 |year= 2006 |pmid= 16960872 |doi= 10.1002/jcb.21035 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Cytoskeletal Proteins}}
{{WikiDoc Sources}}
 
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{{gene-17-stub}}

Revision as of 20:22, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.[1][2]

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.[2]

References

  1. ↑ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.
  2. ↑ 2.0 2.1 "Entrez Gene: MYO1C myosin IC".

Further reading



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