PCTK3: Difference between revisions

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Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene.^[1]^[2]

References

↑ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.
↑ "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. PMC 556772. PMID 1639063.
Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain". Gene. 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID 15019984.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID 16766195.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid1437147-1] Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.

[entrez-2] "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=August 2017}}
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-| update_page = yes
+'''Serine/threonine-protein kinase PCTAIRE-3''' is an [[enzyme]] that in humans is encoded by the ''PCTK3'' [[gene]].<ref name="pmid1437147">{{cite journal |vauthors=Okuda T, Cleveland JL, Downing JR | title = PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family | journal = Oncogene | volume = 7 | issue = 11 | pages = 2249–58 |date=Dec 1992 | pmid = 1437147 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCTK3 PCTAIRE protein kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5129| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = PCTAIRE protein kinase 3
- | HGNCid = 8751
- | Symbol = PCTK3
- | AltSymbols =; PCTAIRE; PCTAIRE3
- | OMIM = 169190
- | ECnumber =
- | Homologene = 1949
- | MGIid = 97518
-  | GeneAtlas_image1 = PBB_GE_PCTK3_214797_s_at_tn.png
-  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5129
-    | Hs_Ensembl = ENSG00000117266
-    | Hs_RefseqProtein = NP_002587
-    | Hs_RefseqmRNA = NM_002596
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 203740350
-    | Hs_GenLoc_end = 203768544
-    | Hs_Uniprot = Q07002
-    | Mm_EntrezGene = 18557
-    | Mm_Ensembl = ENSMUSG00000026437
-    | Mm_RefseqmRNA = NM_008795
-    | Mm_RefseqProtein = NP_032821
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 133941096
-    | Mm_GenLoc_end = 133967174
-    | Mm_Uniprot = Q0VDL5
-  }}
-}}
-'''PCTAIRE protein kinase 3''', also known as '''PCTK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCTK3 PCTAIRE protein kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5129| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 55: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Okuda T, Cleveland JL, Downing JR |title=PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. |journal=Oncogene |volume=7 |issue= 11 |pages= 2249-58 |year= 1992 |pmid= 1437147 |doi=  }}
+*{{cite journal   |vauthors=Meyerson M, Enders GH, Wu CL, etal |title=A family of human cdc2-related protein kinases. |journal=EMBO J. |volume=11 |issue= 8 |pages= 2909–17 |year= 1992 |pmid= 1639063 |doi=  | pmc=556772  }}
-*{{cite journal  | author=Meyerson M, Enders GH, Wu CL, ''et al.'' |title=A family of human cdc2-related protein kinases. |journal=EMBO J. |volume=11 |issue= 8 |pages= 2909-17 |year= 1992 |pmid= 1639063 |doi=  }}
+*{{cite journal  |vauthors=Okuda T, Valentine VA, Shapiro DN, Downing JR |title=Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. |journal=Genomics |volume=21 |issue= 1 |pages= 217–21 |year= 1994 |pmid= 8088790 |doi= 10.1006/geno.1994.1245 }}
-*{{cite journal  | author=Okuda T, Valentine VA, Shapiro DN, Downing JR |title=Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. |journal=Genomics |volume=21 |issue= 1 |pages= 217-21 |year= 1994 |pmid= 8088790 |doi= 10.1006/geno.1994.1245 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  |vauthors=Herskovits AZ, Davies P |title=Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. |journal=Gene |volume=328 |issue=  |pages= 59–67 |year= 2004 |pmid= 15019984 |doi= 10.1016/j.gene.2003.12.011 }}
-*{{cite journal  | author=Herskovits AZ, Davies P |title=Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. |journal=Gene |volume=328 |issue=  |pages= 59-67 |year= 2004 |pmid= 15019984 |doi= 10.1016/j.gene.2003.12.011 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Palmer KJ, Konkel JE, Stephens DJ |title=PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. |journal=J. Cell Sci. |volume=118 |issue= Pt 17 |pages= 3839–47 |year= 2005 |pmid= 16091426 |doi= 10.1242/jcs.02496 }}
-*{{cite journal  | author=Palmer KJ, Konkel JE, Stephens DJ |title=PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. |journal=J. Cell. Sci. |volume=118 |issue= Pt 17 |pages= 3839-47 |year= 2005 |pmid= 16091426 |doi= 10.1242/jcs.02496 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
-*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
+*{{cite journal  |vauthors=Herskovits AZ, Davies P |title=The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. |journal=Neurobiol. Dis. |volume=23 |issue= 2 |pages= 398–408 |year= 2006 |pmid= 16766195 |doi= 10.1016/j.nbd.2006.04.004 }}
-*{{cite journal  | author=Herskovits AZ, Davies P |title=The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. |journal=Neurobiol. Dis. |volume=23 |issue= 2 |pages= 398-408 |year= 2006 |pmid= 16766195 |doi= 10.1016/j.nbd.2006.04.004 }}
+*{{cite journal   |vauthors=Wissing J, Jänsch L, Nimtz M, etal |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
-*{{cite journal  | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
 }}
 {{refend}}
-{{protein-stub}}
+{{Serine/threonine-specific protein kinases}}
-{{WikiDoc Sources}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
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+[[Category:EC 2.7.11]]
+{{gene-1-stub}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

PCTK3: Difference between revisions

Revision as of 20:33, 8 November 2017

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