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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''REST corepressor 1''' also known as '''CoREST''' is a [[protein]] that in humans is encoded by the ''RCOR1'' [[gene]].<ref name="pmid10449787">{{cite journal | vauthors = Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G | title = CoREST: a functional corepressor required for regulation of neural-specific gene expression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9873–8  | date = September 1999 | pmid = 10449787 | pmc = 22303 | doi = 10.1073/pnas.96.17.9873 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RCOR1 REST corepressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23186| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RCOR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2iw5.
| PDB = {{PDB2|2iw5}}, {{PDB2|2uxn}}, {{PDB2|2v1d}}
| Name = REST corepressor 1
| HGNCid = 17441
| Symbol = RCOR1
| AltSymbols =; COREST; KIAA0071; RCOR
| OMIM = 607675
| ECnumber = 
| Homologene = 32246
| MGIid = 106340
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23186
    | Hs_Ensembl = ENSG00000089902
    | Hs_RefseqProtein = NP_055971
    | Hs_RefseqmRNA = NM_015156
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 102128986
    | Hs_GenLoc_end = 102262596
    | Hs_Uniprot = Q9UKL0
    | Mm_EntrezGene = 217864
    | Mm_Ensembl = ENSMUSG00000037896
    | Mm_RefseqmRNA = NM_198023
    | Mm_RefseqProtein = NP_932140
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 111529531
    | Mm_GenLoc_end = 111563702
    | Mm_Uniprot = Q8CFE3
  }}
}}
'''REST corepressor 1''', also known as '''RCOR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RCOR1 REST corepressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23186| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining [[neuron|neural cell]] [[cellular differentiation|differentiation]]. The encoded protein binds to the [[C-terminal]] domain of [[RE1-silencing transcription factor|REST]] (repressor element-1 silencing transcription factor).<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RCOR1 REST corepressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23186| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi=  }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Andrés ME, Burger C, Peral-Rubio MJ, ''et al.'' |title=CoREST: a functional corepressor required for regulation of neural-specific gene expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9873-8 |year= 1999 |pmid= 10449787 |doi=  }}
*{{cite journal  | author=Grimes JA, Nielsen SJ, Battaglioli E, ''et al.'' |title=The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9461-7 |year= 2000 |pmid= 10734093 |doi=  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Humphrey GW, Wang Y, Russanova VR, ''et al.'' |title=Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6817-24 |year= 2001 |pmid= 11102443 |doi= 10.1074/jbc.M007372200 }}
*{{cite journal  | author=You A, Tong JK, Grozinger CM, Schreiber SL |title=CoREST is an integral component of the CoREST- human histone deacetylase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1454-8 |year= 2001 |pmid= 11171972 |doi= 10.1073/pnas.98.4.1454 }}
*{{cite journal  | author=Ballas N, Battaglioli E, Atouf F, ''et al.'' |title=Regulation of neuronal traits by a novel transcriptional complex. |journal=Neuron |volume=31 |issue= 3 |pages= 353-65 |year= 2001 |pmid= 11516394 |doi=  }}
*{{cite journal  | author=Hakimi MA, Bochar DA, Chenoweth J, ''et al.'' |title=A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7420-5 |year= 2002 |pmid= 12032298 |doi= 10.1073/pnas.112008599 }}
*{{cite journal  | author=Battaglioli E, Andrés ME, Rose DW, ''et al.'' |title=REST repression of neuronal genes requires components of the hSWI.SNF complex. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 41038-45 |year= 2002 |pmid= 12192000 |doi= 10.1074/jbc.M205691200 }}
*{{cite journal  | author=Lunyak VV, Burgess R, Prefontaine GG, ''et al.'' |title=Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. |journal=Science |volume=298 |issue= 5599 |pages= 1747-52 |year= 2002 |pmid= 12399542 |doi= 10.1126/science.1076469 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hakimi MA, Dong Y, Lane WS, ''et al.'' |title=A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7234-9 |year= 2003 |pmid= 12493763 |doi= 10.1074/jbc.M208992200 }}
*{{cite journal  | author=Iwase S, Januma A, Miyamoto K, ''et al.'' |title=Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. |journal=Biochem. Biophys. Res. Commun. |volume=322 |issue= 2 |pages= 601-8 |year= 2004 |pmid= 15325272 |doi= 10.1016/j.bbrc.2004.07.163 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gu H, Liang Y, Mandel G, Roizman B |title=Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7571-6 |year= 2005 |pmid= 15897453 |doi= 10.1073/pnas.0502658102 }}
*{{cite journal  | author=Lee MG, Wynder C, Cooch N, Shiekhattar R |title=An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. |journal=Nature |volume=437 |issue= 7057 |pages= 432-5 |year= 2005 |pmid= 16079794 |doi= 10.1038/nature04021 }}
*{{cite journal  | author=Shi YJ, Matson C, Lan F, ''et al.'' |title=Regulation of LSD1 histone demethylase activity by its associated factors. |journal=Mol. Cell |volume=19 |issue= 6 |pages= 857-64 |year= 2005 |pmid= 16140033 |doi= 10.1016/j.molcel.2005.08.027 }}
*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
}}
{{refend}}


{{protein-stub}}
RCOR1 has been shown to [[Protein-protein interaction|interact]] with
{{WikiDoc Sources}}
* [[HDAC1]],<ref name=pmid12032298/><ref name="pmid11171972">{{cite journal | vauthors = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 4 | pages = 1454–8  | date = February 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454 }}</ref>
* [[Histone deacetylase 2|HDAC2]],<ref name=pmid12032298/><ref name=pmid11171972/>
* [[HMG20B]],<ref name="pmid12032298">{{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7420–5  | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 }}</ref>
* [[RE1-silencing transcription factor|REST]]<ref name="pmid10449787" /> and
* [[PHF21A]].<ref name=pmid12032298/><ref name="pmid15325272">{{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochem. Biophys. Res. Commun. | volume = 322 | issue = 2 | pages = 601–8  | date = September 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}</ref>
 
== References ==
{{Reflist}}
{{Clear}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res. | volume = 1 | issue = 5 | pages = 223–9 | year = 1994 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
* {{cite journal | vauthors = Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T | title = The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex | journal = J. Biol. Chem. | volume = 275 | issue = 13 | pages = 9461–7 | year = 2000 | pmid = 10734093 | doi = 10.1074/jbc.275.13.9461 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH | title = Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 | journal = J. Biol. Chem. | volume = 276 | issue = 9 | pages = 6817–24 | year = 2001 | pmid = 11102443 | doi = 10.1074/jbc.M007372200 }}
* {{cite journal | vauthors = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 4 | pages = 1454–8 | year = 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454 }}
* {{cite journal | vauthors = Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G | title = Regulation of neuronal traits by a novel transcriptional complex | journal = Neuron | volume = 31 | issue = 3 | pages = 353–65 | year = 2001 | pmid = 11516394 | doi = 10.1016/S0896-6273(01)00371-3 }}
* {{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7420–5 | year = 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 }}
* {{cite journal | vauthors = Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G | title = REST repression of neuronal genes requires components of the hSWI.SNF complex | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 41038–45 | year = 2002 | pmid = 12192000 | doi = 10.1074/jbc.M205691200 }}
* {{cite journal | vauthors = Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG | title = Corepressor-dependent silencing of chromosomal regions encoding neuronal genes | journal = Science | volume = 298 | issue = 5599 | pages = 1747–52 | year = 2002 | pmid = 12399542 | doi = 10.1126/science.1076469 }}
* {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7234–9 | year = 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
* {{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochem. Biophys. Res. Commun. | volume = 322 | issue = 2 | pages = 601–8 | year = 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}
* {{cite journal | vauthors = Gu H, Liang Y, Mandel G, Roizman B | title = Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 21 | pages = 7571–6 | year = 2005 | pmid = 15897453 | pmc = 1140450 | doi = 10.1073/pnas.0502658102 }}
* {{cite journal | vauthors = Lee MG, Wynder C, Cooch N, Shiekhattar R | title = An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation | journal = Nature | volume = 437 | issue = 7057 | pages = 432–5 | year = 2005 | pmid = 16079794 | doi = 10.1038/nature04021 }}
* {{cite journal | vauthors = Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y | title = Regulation of LSD1 histone demethylase activity by its associated factors | journal = Mol. Cell | volume = 19 | issue = 6 | pages = 857–64 | year = 2005 | pmid = 16140033 | doi = 10.1016/j.molcel.2005.08.027 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
{{Refend}}
 
{{PDB Gallery|geneid=23186}}
{{Transcription coregulators}}
 
{{NLM content}}
 
 
{{Gene-14-stub}}

Latest revision as of 09:02, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.[1][2]

Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).[2]

Interactions

RCOR1 has been shown to interact with

References

  1. ↑ 1.0 1.1 Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. doi:10.1073/pnas.96.17.9873. PMC 22303. PMID 10449787.
  2. ↑ 2.0 2.1 "Entrez Gene: RCOR1 REST corepressor 1".
  3. ↑ 3.0 3.1 3.2 3.3 Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
  4. ↑ 4.0 4.1 You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
  5. ↑ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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