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{{Infobox_gene}}
{{PBB_Controls
'''Neutral amino acid transporter A''' is a [[protein]] that in humans is encoded by the ''SLC1A4'' [[gene]].<ref name="pmid7896285">{{cite journal | vauthors = Hofmann K, Duker M, Fink T, Lichter P, Stoffel W | title = Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15 | journal = Genomics | volume = 24 | issue = 1 | pages = 20–6 |date=Apr 1995 | pmid = 7896285 | pmc =  | doi = 10.1006/geno.1994.1577 }}</ref><ref name="pmid8910405">{{cite journal | vauthors = Zerangue N, Kavanaugh MP | title = ASCT-1 is a neutral amino acid exchanger with chloride channel activity | journal = J Biol Chem | volume = 271 | issue = 45 | pages = 27991–4 |date=Dec 1996 | pmid = 8910405 | pmc = | doi =10.1074/jbc.271.45.27991  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6509| accessdate = }}</ref>
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In melanocytic cells SLC1A4 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal |vauthors=Hoek KS, Schlegel NC, Eichhoff OM, etal | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
{{GNF_Protein_box
  | image =
| image_source = 
| PDB =
| Name = Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
| HGNCid = 10942
| Symbol = SLC1A4
| AltSymbols =; ASCT1; SATT
| OMIM = 600229
| ECnumber =
| Homologene = 20655
| MGIid = 2135601
| GeneAtlas_image1 = PBB_GE_SLC1A4_209610_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC1A4_209611_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC1A4_212810_s_at_tn.png
| Function = {{GNF_GO|id=GO:0015175 |text = neutral amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0017153 |text = sodium:dicarboxylate symporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006835 |text = dicarboxylic acid transport}} {{GNF_GO|id=GO:0015804 |text = neutral amino acid transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6509
    | Hs_Ensembl = ENSG00000115902
    | Hs_RefseqProtein = NP_003029
    | Hs_RefseqmRNA = NM_003038
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 65070098
    | Hs_GenLoc_end = 65104501
    | Hs_Uniprot = P43007
    | Mm_EntrezGene = 55963
    | Mm_Ensembl = ENSMUSG00000020142
    | Mm_RefseqmRNA = NM_018861
    | Mm_RefseqProtein = NP_061349
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 20202208
    | Mm_GenLoc_end = 20232674
    | Mm_Uniprot = Q3US35
  }}
}}
'''Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4''', also known as '''SLC1A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6509| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Arriza JL, Kavanaugh MP, Fairman WA, etal |title=Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. |journal=J. Biol. Chem. |volume=268 |issue= 21 |pages= 15329–32 |year= 1993 |pmid= 8101838 |doi=  }}
| citations =
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Hofmann K, Düker M, Fink T, ''et al.'' |title=Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. |journal=Genomics |volume=24 |issue= 1 |pages= 20-6 |year= 1995 |pmid= 7896285 |doi= 10.1006/geno.1994.1577 }}
*{{cite journal   |vauthors=Shafqat S, Tamarappoo BK, Kilberg MS, etal |title=Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. |journal=J. Biol. Chem. |volume=268 |issue= 21 |pages= 15351–5 |year= 1993 |pmid= 8340364 |doi=  }}
*{{cite journal | author=Arriza JL, Kavanaugh MP, Fairman WA, ''et al.'' |title=Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. |journal=J. Biol. Chem. |volume=268 |issue= 21 |pages= 15329-32 |year= 1993 |pmid= 8101838 |doi=  }}
*{{cite journal  | vauthors=Tamarappoo BK, McDonald KK, Kilberg MS |title=Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity. |journal=Biochim. Biophys. Acta |volume=1279 |issue= 2 |pages= 131–6 |year= 1996 |pmid= 8603078 |doi=10.1016/0005-2736(95)00259-6 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Shafqat S, Tamarappoo BK, Kilberg MS, ''et al.'' |title=Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. |journal=J. Biol. Chem. |volume=268 |issue= 21 |pages= 15351-5 |year= 1993 |pmid= 8340364 |doi=  }}
*{{cite journal  | vauthors=Marin M, Tailor CS, Nouri A, Kabat D |title=Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. |journal=J. Virol. |volume=74 |issue= 17 |pages= 8085–93 |year= 2000 |pmid= 10933718 | pmc=112341 |doi=10.1128/JVI.74.17.8085-8093.2000 }}
*{{cite journal  | author=Tamarappoo BK, McDonald KK, Kilberg MS |title=Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity. |journal=Biochim. Biophys. Acta |volume=1279 |issue= 2 |pages= 131-6 |year= 1996 |pmid= 8603078 |doi= }}
*{{cite journal   |vauthors=Younes M, Pathak M, Finnie D, etal |title=Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas. |journal=Anticancer Res. |volume=20 |issue= 5C |pages= 3775–9 |year= 2001 |pmid= 11268453 |doi=  }}
*{{cite journal  | author=Zerangue N, Kavanaugh MP |title=ASCT-1 is a neutral amino acid exchanger with chloride channel activity. |journal=J. Biol. Chem. |volume=271 |issue= 45 |pages= 27991-4 |year= 1996 |pmid= 8910405 |doi= }}
*{{cite journal  | vauthors=Pinilla J, Barber A, Lostao MP |title=Active transport of alanine by the neutral amino-acid exchanger ASCT1. |journal=Can. J. Physiol. Pharmacol. |volume=79 |issue= 12 |pages= 1023–9 |year= 2002 |pmid= 11824937 |doi=10.1139/cjpp-79-12-1023 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Lavillette D, Marin M, Ruggieri A, etal |title=The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. |journal=J. Virol. |volume=76 |issue= 13 |pages= 6442–52 |year= 2002 |pmid= 12050356 | pmc=136247 |doi=10.1128/JVI.76.13.6442-6452.2002 }}
*{{cite journal  | author=Marin M, Tailor CS, Nouri A, Kabat D |title=Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. |journal=J. Virol. |volume=74 |issue= 17 |pages= 8085-93 |year= 2000 |pmid= 10933718 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Younes M, Pathak M, Finnie D, ''et al.'' |title=Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas. |journal=Anticancer Res. |volume=20 |issue= 5C |pages= 3775-9 |year= 2001 |pmid= 11268453 |doi=  }}
*{{cite journal  | vauthors=Marin M, Lavillette D, Kelly SM, Kabat D |title=N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. |journal=J. Virol. |volume=77 |issue= 5 |pages= 2936–45 |year= 2003 |pmid= 12584318 | pmc=149750 |doi=10.1128/JVI.77.5.2936-2945.2003 }}
*{{cite journal  | author=Pinilla J, Barber A, Lostao MP |title=Active transport of alanine by the neutral amino-acid exchanger ASCT1. |journal=Can. J. Physiol. Pharmacol. |volume=79 |issue= 12 |pages= 1023-9 |year= 2002 |pmid= 11824937 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 | pmc=528928 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Lavillette D, Marin M, Ruggieri A, ''et al.'' |title=The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. |journal=J. Virol. |volume=76 |issue= 13 |pages= 6442-52 |year= 2002 |pmid= 12050356 |doi=  }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Chi A, Valencia JC, Hu ZZ, etal |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal  | author=Marin M, Lavillette D, Kelly SM, Kabat D |title=N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. |journal=J. Virol. |volume=77 |issue= 5 |pages= 2936-45 |year= 2003 |pmid= 12584318 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins|bg|bg0}}
 
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:27, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.[1][2][3]

In melanocytic cells SLC1A4 gene expression may be regulated by MITF.[4]

See also

References

  1. ↑ Hofmann K, Duker M, Fink T, Lichter P, Stoffel W (Apr 1995). "Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15". Genomics. 24 (1): 20–6. doi:10.1006/geno.1994.1577. PMID 7896285.
  2. ↑ Zerangue N, Kavanaugh MP (Dec 1996). "ASCT-1 is a neutral amino acid exchanger with chloride channel activity". J Biol Chem. 271 (45): 27991–4. doi:10.1074/jbc.271.45.27991. PMID 8910405.
  3. ↑ "Entrez Gene: SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4".
  4. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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