SLC22A2: Difference between revisions

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Latest revision as of 06:28, 11 September 2017

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.^[1]^[2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.^[2]

References

↑ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
↑ ^2.0 ^2.1 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMC 238269. PMID 1727476.
Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421.
Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060.
Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 (1): 155–8. PMC 1218171. PMID 9078256.
Gorboulev V, Ulzheimer JC, Akhoundova A, et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930.
Busch AE, Karbach U, Miska D, et al. (1998). "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine". Mol. Pharmacol. 54 (2): 342–52. PMID 9687576.
Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2". Hum. Genet. 106 (6): 627–35. doi:10.1007/s004390050035. PMID 10942111.
Pietig G, Mehrens T, Hirsch JR, et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.
Boehm J, He Y, Greiner A, et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMC 149152. PMID 11483518.
Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. Biol. Chem. 277 (25): 22491–6. doi:10.1074/jbc.M203114200. PMID 11953440.
Urakami Y, Akazawa M, Saito H, et al. (2002). "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney". J. Am. Soc. Nephrol. 13 (7): 1703–10. doi:10.1097/01.ASN.0000019413.78751.46. PMID 12089365.
Leabman MK, Huang CC, Kawamoto M, et al. (2003). "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function". Pharmacogenetics. 12 (5): 395–405. doi:10.1097/00008571-200207000-00007. PMID 12142729.
Cetinkaya I, Ciarimboli G, Yalçinkaya G, et al. (2003). "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Am. J. Physiol. Renal Physiol. 284 (2): F293–302. doi:10.1152/ajprenal.00251.2002. PMID 12388397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837.
Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
Lips KS, Volk C, Schmitt BM, et al. (2005). "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium". Am. J. Respir. Cell Mol. Biol. 33 (1): 79–88. doi:10.1165/rcmb.2004-0363OC. PMID 15817714.
Jiang W, Prokopenko O, Wong L, et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMC 1190334. PMID 16024787.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid9605850-1] Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.

[entrez-2] 2.0 ^2.1 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Solute carrier family 22 member 2''' is a [[protein]] that in humans is encoded by the ''SLC22A2'' [[gene]].<ref name="pmid9605850">{{cite journal | vauthors = Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M | title = The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26 | journal = Cytogenet Cell Genet | volume = 79 | issue = 3-4 | pages = 198–200 |date=Jun 1998 | pmid = 9605850 | pmc =  | doi =10.1159/000134720  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 22 (organic cation transporter), member 2
- | HGNCid = 10966
- | Symbol = SLC22A2
- | AltSymbols =; OCT2; MGC32628
- | OMIM = 602608
- | ECnumber =
- | Homologene = 68293
- | MGIid = 1335072
- | GeneAtlas_image1 = PBB_GE_SLC22A2_207429_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015075 |text = ion transmembrane transporter activity}} {{GNF_GO|id=GO:0015101 |text = organic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
-  | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0007589 |text = fluid secretion}} {{GNF_GO|id=GO:0015695 |text = organic cation transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6582
-    | Hs_Ensembl = ENSG00000112499
-    | Hs_RefseqProtein = NP_003049
-    | Hs_RefseqmRNA = NM_003058
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 160557784
-    | Hs_GenLoc_end = 160618660
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 20518
-    | Mm_Ensembl = ENSMUSG00000040966
-    | Mm_RefseqmRNA = NM_013667
-    | Mm_RefseqProtein = NP_038695
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 12427547
-    | Mm_GenLoc_end = 12471862
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 22 (organic cation transporter), member 2''', also known as '''SLC22A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
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 {{PBB_Summary
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-| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
+| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
 }}
@@ Line 58: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 64: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Berkhout B, Jeang KT |title=Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. |journal=J. Virol. |volume=66 |issue= 1 |pages= 139-49 |year= 1992 |pmid= 1727476 |doi=  }}
+*{{cite journal  | vauthors=Berkhout B, Jeang KT |title=Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. |journal=J. Virol. |volume=66 |issue= 1 |pages= 139–49 |year= 1992 |pmid= 1727476 |doi=  | pmc=238269  }}
-*{{cite journal  | author=Jeang KT, Chun R, Lin NH, ''et al.'' |title=In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. |journal=J. Virol. |volume=67 |issue= 10 |pages= 6224-33 |year= 1993 |pmid= 7690421 |doi=  }}
+*{{cite journal   |vauthors=Jeang KT, Chun R, Lin NH, etal |title=In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. |journal=J. Virol. |volume=67 |issue= 10 |pages= 6224–33 |year= 1993 |pmid= 7690421 |doi=  | pmc=238044  }}
-*{{cite journal  | author=Liu YZ, Lania L, Latchman DS |title=Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. |journal=AIDS |volume=10 |issue= 12 |pages= 1323-9 |year= 1997 |pmid= 8902060 |doi=  }}
+*{{cite journal  | vauthors=Liu YZ, Lania L, Latchman DS |title=Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. |journal=AIDS |volume=10 |issue= 12 |pages= 1323–9 |year= 1997 |pmid= 8902060 |doi=10.1097/00002030-199610000-00003  }}
-*{{cite journal  | author=Liu YZ, Latchman DS |title=The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. |journal=Biochem. J. |volume=322 ( Pt 1) |issue=  |pages= 155-8 |year= 1997 |pmid= 9078256 |doi=  }}
+*{{cite journal  | vauthors=Liu YZ, Latchman DS |title=The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. |journal=Biochem. J. |volume=322 |issue=  1|pages= 155–8 |year= 1997 |pmid= 9078256 |doi=  | pmc=1218171  }}
-*{{cite journal  | author=Gorboulev V, Ulzheimer JC, Akhoundova A, ''et al.'' |title=Cloning and characterization of two human polyspecific organic cation transporters. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 871-81 |year= 1997 |pmid= 9260930 |doi=  }}
+*{{cite journal   |vauthors=Gorboulev V, Ulzheimer JC, Akhoundova A, etal |title=Cloning and characterization of two human polyspecific organic cation transporters. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 871–81 |year= 1997 |pmid= 9260930 |doi=10.1089/dna.1997.16.871  }}
-*{{cite journal  | author=Koehler MR, Wissinger B, Gorboulev V, ''et al.'' |title=The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 198-200 |year= 1998 |pmid= 9605850 |doi=  }}
+*{{cite journal   |vauthors=Busch AE, Karbach U, Miska D, etal |title=Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. |journal=Mol. Pharmacol. |volume=54 |issue= 2 |pages= 342–52 |year= 1998 |pmid= 9687576 |doi=  }}
-*{{cite journal  | author=Busch AE, Karbach U, Miska D, ''et al.'' |title=Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. |journal=Mol. Pharmacol. |volume=54 |issue= 2 |pages= 342-52 |year= 1998 |pmid= 9687576 |doi=  }}
+*{{cite journal  | vauthors=Verhaagh S, Schweifer N, Barlow DP, Zwart R |title=Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. |journal=Genomics |volume=55 |issue= 2 |pages= 209–18 |year= 1999 |pmid= 9933568 |doi= 10.1006/geno.1998.5639 }}
-*{{cite journal  | author=Verhaagh S, Schweifer N, Barlow DP, Zwart R |title=Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. |journal=Genomics |volume=55 |issue= 2 |pages= 209-18 |year= 1999 |pmid= 9933568 |doi= 10.1006/geno.1998.5639 }}
+*{{cite journal  | vauthors=Gründemann D, Schömig E |title=Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 627–35 |year= 2000 |pmid= 10942111 |doi=10.1007/s004390050035  }}
-*{{cite journal  | author=Gründemann D, Schömig E |title=Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 627-35 |year= 2000 |pmid= 10942111 |doi=  }}
+*{{cite journal   |vauthors=Pietig G, Mehrens T, Hirsch JR, etal |title=Properties and regulation of organic cation transport in freshly isolated human proximal tubules. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33741–6 |year= 2001 |pmid= 11447227 |doi= 10.1074/jbc.M104617200 }}
-*{{cite journal  | author=Pietig G, Mehrens T, Hirsch JR, ''et al.'' |title=Properties and regulation of organic cation transport in freshly isolated human proximal tubules. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33741-6 |year= 2001 |pmid= 11447227 |doi= 10.1074/jbc.M104617200 }}
+*{{cite journal   |vauthors=Boehm J, He Y, Greiner A, etal |title=Regulation of BOB.1/OBF.1 stability by SIAH. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4153–62 |year= 2001 |pmid= 11483518 |doi= 10.1093/emboj/20.15.4153  | pmc=149152 }}
-*{{cite journal  | author=Boehm J, He Y, Greiner A, ''et al.'' |title=Regulation of BOB.1/OBF.1 stability by SIAH. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4153-62 |year= 2001 |pmid= 11483518 |doi= 10.1093/emboj/20.15.4153 }}
+*{{cite journal  | vauthors=Barendt WM, Wright SH |title=The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22491–6 |year= 2002 |pmid= 11953440 |doi= 10.1074/jbc.M203114200 }}
-*{{cite journal  | author=Barendt WM, Wright SH |title=The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22491-6 |year= 2002 |pmid= 11953440 |doi= 10.1074/jbc.M203114200 }}
+*{{cite journal   |vauthors=Urakami Y, Akazawa M, Saito H, etal |title=cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 7 |pages= 1703–10 |year= 2002 |pmid= 12089365 |doi=10.1097/01.ASN.0000019413.78751.46  }}
-*{{cite journal  | author=Urakami Y, Akazawa M, Saito H, ''et al.'' |title=cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 7 |pages= 1703-10 |year= 2002 |pmid= 12089365 |doi=  }}
+*{{cite journal   |vauthors=Leabman MK, Huang CC, Kawamoto M, etal |title=Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 395–405 |year= 2003 |pmid= 12142729 |doi=10.1097/00008571-200207000-00007  }}
-*{{cite journal  | author=Leabman MK, Huang CC, Kawamoto M, ''et al.'' |title=Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 395-405 |year= 2003 |pmid= 12142729 |doi=  }}
+*{{cite journal   |vauthors=Cetinkaya I, Ciarimboli G, Yalçinkaya G, etal |title=Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F293–302 |year= 2003 |pmid= 12388397 |doi= 10.1152/ajprenal.00251.2002 }}
-*{{cite journal  | author=Cetinkaya I, Ciarimboli G, Yalçinkaya G, ''et al.'' |title=Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F293-302 |year= 2003 |pmid= 12388397 |doi= 10.1152/ajprenal.00251.2002 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Gründemann D, Hahne C, Berkels R, Schömig E |title=Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 2 |pages= 810–7 |year= 2003 |pmid= 12538837 |doi= 10.1124/jpet.102.044404 }}
-*{{cite journal  | author=Gründemann D, Hahne C, Berkels R, Schömig E |title=Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 2 |pages= 810-7 |year= 2003 |pmid= 12538837 |doi= 10.1124/jpet.102.044404 }}
+*{{cite journal   |vauthors=Bottalico B, Larsson I, Brodszki J, etal |title=Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. |journal=Placenta |volume=25 |issue= 6 |pages= 518–29 |year= 2004 |pmid= 15135235 |doi= 10.1016/j.placenta.2003.10.017 }}
-*{{cite journal  | author=Bottalico B, Larsson I, Brodszki J, ''et al.'' |title=Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. |journal=Placenta |volume=25 |issue= 6 |pages= 518-29 |year= 2004 |pmid= 15135235 |doi= 10.1016/j.placenta.2003.10.017 }}
+*{{cite journal   |vauthors=Lips KS, Volk C, Schmitt BM, etal |title=Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue= 1 |pages= 79–88 |year= 2005 |pmid= 15817714 |doi= 10.1165/rcmb.2004-0363OC }}
-*{{cite journal  | author=Lips KS, Volk C, Schmitt BM, ''et al.'' |title=Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue= 1 |pages= 79-88 |year= 2005 |pmid= 15817714 |doi= 10.1165/rcmb.2004-0363OC }}
+*{{cite journal   |vauthors=Jiang W, Prokopenko O, Wong L, etal |title=IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6496–508 |year= 2005 |pmid= 16024787 |doi= 10.1128/MCB.25.15.6496-6508.2005  | pmc=1190334 }}
-*{{cite journal  | author=Jiang W, Prokopenko O, Wong L, ''et al.'' |title=IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6496-508 |year= 2005 |pmid= 16024787 |doi= 10.1128/MCB.25.15.6496-6508.2005 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC22A2: Difference between revisions

Latest revision as of 06:28, 11 September 2017

See also

References

Further reading

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