SLC25A10: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitochondrial dicarboxylate carrier''' is a [[protein]] that in humans is encoded by the ''SLC25A10'' [[gene]].<ref name="pmid9733776">{{cite journal | vauthors = Fiermonte G, Palmieri L, Dolce V, Lasorsa FM, Palmieri F, Runswick MJ, Walker JE | title = The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24754–9 | date = September 1998 | pmid = 9733776 | pmc =  | doi = 10.1074/jbc.273.38.24754 }}</ref><ref name="pmid10072589">{{cite journal | vauthors = Pannone E, Fiermonte G, Dolce V, Rocchi M, Palmieri F | title = Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3 | journal = Cytogenetics and Cell Genetics | volume = 83 | issue = 3-4 | pages = 238–9 | date = Mar 1999 | pmid = 10072589 | pmc = | doi = 10.1159/000015190 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1468| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
| HGNCid = 10980
| Symbol = SLC25A10
| AltSymbols =; DIC
| OMIM = 606794
| ECnumber = 
| Homologene = 6519
| MGIid = 1353497
| GeneAtlas_image1 = PBB_GE_SLC25A10_218275_at_tn.png
| Function = {{GNF_GO|id=GO:0005310 |text = dicarboxylic acid transmembrane transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006094 |text = gluconeogenesis}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006835 |text = dicarboxylic acid transport}} {{GNF_GO|id=GO:0006839 |text = mitochondrial transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1468
    | Hs_Ensembl = ENSG00000183048
    | Hs_RefseqProtein = NP_036272
    | Hs_RefseqmRNA = NM_012140
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77289742
    | Hs_GenLoc_end = 77298446
    | Hs_Uniprot = Q9UBX3
    | Mm_EntrezGene = 27376
    | Mm_Ensembl = ENSMUSG00000025792
    | Mm_RefseqmRNA = NM_013770
    | Mm_RefseqProtein = NP_038798
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120307952
    | Mm_GenLoc_end = 120317251
    | Mm_Uniprot = Q9QZD8
  }}
}}
'''Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10''', also known as '''SLC25A10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1468| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1468| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fiermonte G, Dolce V, Arrigoni R, Runswick MJ, Walker JE, Palmieri F | title = Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family | journal = The Biochemical Journal | volume = 344 Pt 3 | issue = Pt 3 | pages = 953–60 | date = December 1999 | pmid = 10585886 | pmc = 1220721 | doi = 10.1042/0264-6021:3440953 }}
| citations =
* {{cite journal | vauthors = Douglas MW, Diefenbach RJ, Homa FL, Miranda-Saksena M, Rixon FJ, Vittone V, Byth K, Cunningham AL | title = Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport | journal = The Journal of Biological Chemistry | volume = 279 | issue = 27 | pages = 28522–30 | date = July 2004 | pmid = 15117959 | doi = 10.1074/jbc.M311671200 }}
*{{cite journal | author=Fiermonte G, Palmieri L, Dolce V, ''et al.'' |title=The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24754-9 |year= 1998 |pmid= 9733776 |doi=  }}
* {{cite journal | vauthors = Mizuarai S, Miki S, Araki H, Takahashi K, Kotani H | title = Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis | journal = The Journal of Biological Chemistry | volume = 280 | issue = 37 | pages = 32434–41 | date = September 2005 | pmid = 16027120 | doi = 10.1074/jbc.M503152200 }}
*{{cite journal  | author=Pannone E, Fiermonte G, Dolce V, ''et al.'' |title=Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 238-9 |year= 1999 |pmid= 10072589 |doi=  }}
* {{cite journal | vauthors = Khanna H, Hurd TW, Lillo C, Shu X, Parapuram SK, He S, Akimoto M, Wright AF, Margolis B, Williams DS, Swaroop A | title = RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins | journal = The Journal of Biological Chemistry | volume = 280 | issue = 39 | pages = 33580–7 | date = September 2005 | pmid = 16043481 | pmc = 1249479 | doi = 10.1074/jbc.M505827200 }}
*{{cite journal  | author=Fiermonte G, Dolce V, Arrigoni R, ''et al.'' |title=Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. |journal=Biochem. J. |volume=344 Pt 3 |issue= |pages= 953-60 |year= 2000 |pmid= 10585886 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Douglas MW, Diefenbach RJ, Homa FL, ''et al.'' |title=Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28522-30 |year= 2004 |pmid= 15117959 |doi= 10.1074/jbc.M311671200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Mizuarai S, Miki S, Araki H, ''et al.'' |title=Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. |journal=J. Biol. Chem. |volume=280 |issue= 37 |pages= 32434-41 |year= 2005 |pmid= 16027120 |doi= 10.1074/jbc.M503152200 }}
*{{cite journal | author=Khanna H, Hurd TW, Lillo C, ''et al.'' |title=RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. |journal=J. Biol. Chem. |volume=280 |issue= 39 |pages= 33580-7 |year= 2005 |pmid= 16043481 |doi= 10.1074/jbc.M505827200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Revision as of 15:27, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitochondrial dicarboxylate carrier is a protein that in humans is encoded by the SLC25A10 gene.[1][2][3]

Function

The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.[supplied by OMIM][3]

See also

References

  1. ↑ Fiermonte G, Palmieri L, Dolce V, Lasorsa FM, Palmieri F, Runswick MJ, Walker JE (September 1998). "The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans". The Journal of Biological Chemistry. 273 (38): 24754–9. doi:10.1074/jbc.273.38.24754. PMID 9733776.
  2. ↑ Pannone E, Fiermonte G, Dolce V, Rocchi M, Palmieri F (Mar 1999). "Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3". Cytogenetics and Cell Genetics. 83 (3–4): 238–9. doi:10.1159/000015190. PMID 10072589.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=SLC25A10&oldid=1418082"