SLC36A1: Difference between revisions

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Latest revision as of 06:32, 11 September 2017

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.^[1]^[2]^[3]

This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.^[3]

References

↑ Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem. 277 (25): 22966–73. doi:10.1074/jbc.M200374200. PMID 11959859.
↑ Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A. 98 (13): 7206–11. doi:10.1073/pnas.121183498. PMC 34647. PMID 11390972.
↑ ^3.0 ^3.1 "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Chen Z, Fei YJ, Anderson CM, et al. (2003). "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2". J. Physiol. 546 (Pt 2): 349–61. doi:10.1113/jphysiol.2002.026500. PMC 2342508. PMID 12527723.
Wreden CC, Johnson J, Tran C, et al. (2003). "The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons". J. Neurosci. 23 (4): 1265–75. PMID 12598615.
Boll M, Foltz M, Rubio-Aliaga I, Daniel H (2004). "A cluster of proton/amino acid transporter genes in the human and mouse genomes". Genomics. 82 (1): 47–56. doi:10.1016/S0888-7543(03)00099-5. PMID 12809675.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bermingham JR, Pennington J (2004). "Organization and expression of the SLC36 cluster of amino acid transporter genes". Mamm. Genome. 15 (2): 114–25. doi:10.1007/s00335-003-2319-3. PMID 15058382.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Anderson CM, Grenade DS, Boll M, et al. (2004). "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat". Gastroenterology. 127 (5): 1410–22. doi:10.1053/j.gastro.2004.08.017. PMID 15521011.
Anderson CM, Thwaites DT (2005). "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)". J. Cell. Physiol. 204 (2): 604–13. doi:10.1002/jcp.20337. PMID 15754324.
Abbot EL, Grenade DS, Kennedy DJ, et al. (2006). "Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1". Br. J. Pharmacol. 147 (3): 298–306. doi:10.1038/sj.bjp.0706557. PMC 1751303. PMID 16331283.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kuan YH, Gruebl T, Soba P, et al. (2007). "PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2". J. Biol. Chem. 281 (52): 40114–23. doi:10.1074/jbc.M605407200. PMID 17050537.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid11959859-1] Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem. 277 (25): 22966–73. doi:10.1074/jbc.M200374200. PMID 11959859.

[pmid11390972-2] Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A. 98 (13): 7206–11. doi:10.1073/pnas.121183498. PMC 34647. PMID 11390972.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Proton-coupled amino acid transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC36A1'' [[gene]].<ref name="pmid11959859">{{cite journal | vauthors = Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H | title = Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters | journal = J Biol Chem | volume = 277 | issue = 25 | pages = 22966–73 |date=Jun 2002 | pmid = 11959859 | pmc =  | doi = 10.1074/jbc.M200374200 }}</ref><ref name="pmid11390972">{{cite journal | vauthors = Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B | title = Identification and characterization of a lysosomal transporter for small neutral amino acids | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 13 | pages = 7206–11 |date=Jun 2001 | pmid = 11390972 | pmc = 34647 | doi = 10.1073/pnas.121183498 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 36 (proton/amino acid symporter), member 1
- | HGNCid = 18761
- | Symbol = SLC36A1
- | AltSymbols =; PAT1; LYAAT1; TRAMD3
- | OMIM = 606561
- | ECnumber =
- | Homologene = 70571
- | MGIid = 2445299
-  | GeneAtlas_image1 = PBB_GE_SLC36A1_213119_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC36A1_gnf1h01641_at_tn.png
- | GeneAtlas_image3 = PBB_GE_SLC36A1_gnf1h01642_at_tn.png
- | Function = {{GNF_GO|id=GO:0005280 |text = hydrogen:amino acid symporter activity}} {{GNF_GO|id=GO:0015171 |text = amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015180 |text = L-alanine transmembrane transporter activity}} {{GNF_GO|id=GO:0015187 |text = glycine transmembrane transporter activity}} {{GNF_GO|id=GO:0015193 |text = L-proline transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}}
- | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0015808 |text = L-alanine transport}} {{GNF_GO|id=GO:0015816 |text = glycine transport}} {{GNF_GO|id=GO:0015824 |text = proline transport}} {{GNF_GO|id=GO:0015992 |text = proton transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 206358
-    | Hs_Ensembl = ENSG00000123643
-    | Hs_RefseqProtein = NP_510968
-    | Hs_RefseqmRNA = NM_078483
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 150807356
-    | Hs_GenLoc_end = 150852132
-    | Hs_Uniprot = Q7Z2H8
-    | Mm_EntrezGene = 215335
-    | Mm_Ensembl = ENSMUSG00000020261
-    | Mm_RefseqmRNA = NM_153139
-    | Mm_RefseqProtein = NP_694779
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 55047793
-    | Mm_GenLoc_end = 55077329
-    | Mm_Uniprot = Q5F227
-  }}
-}}
-'''Solute carrier family 36 (proton/amino acid symporter), member 1''', also known as '''SLC36A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.<ref name="entrez">{{cite web | title = Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358| accessdate = }}</ref>
+| summary_text = This gene encodes a member of the eukaryote-specific [[AAAP Family|amino acid/auxin permease (AAAP)]] 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.<ref name="entrez"/>
 }}
@@ Line 60: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 66: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
-*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
+*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
-*{{cite journal  | author=Sagné C, Agulhon C, Ravassard P, ''et al.'' |title=Identification and characterization of a lysosomal transporter for small neutral amino acids. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7206-11 |year= 2001 |pmid= 11390972 |doi= 10.1073/pnas.121183498 }}
+*{{cite journal   |vauthors=Chen Z, Fei YJ, Anderson CM, etal |title=Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2 |journal=J. Physiol. |volume=546 |issue= Pt 2 |pages= 349–61 |year= 2003 |pmid= 12527723 |doi=10.1113/jphysiol.2002.026500  | pmc=2342508  }}
-*{{cite journal  | author=Boll M, Foltz M, Rubio-Aliaga I, ''et al.'' |title=Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22966-73 |year= 2002 |pmid= 11959859 |doi= 10.1074/jbc.M200374200 }}
+*{{cite journal   |vauthors=Wreden CC, Johnson J, Tran C, etal |title=The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1265–75 |year= 2003 |pmid= 12598615 |doi=  }}
-*{{cite journal  | author=Chen Z, Fei YJ, Anderson CM, ''et al.'' |title=Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. |journal=J. Physiol. (Lond.) |volume=546 |issue= Pt 2 |pages= 349-61 |year= 2003 |pmid= 12527723 |doi=  }}
+*{{cite journal  | vauthors=Boll M, Foltz M, Rubio-Aliaga I, Daniel H |title=A cluster of proton/amino acid transporter genes in the human and mouse genomes |journal=Genomics |volume=82 |issue= 1 |pages= 47–56 |year= 2004 |pmid= 12809675 |doi=10.1016/S0888-7543(03)00099-5  }}
-*{{cite journal  | author=Wreden CC, Johnson J, Tran C, ''et al.'' |title=The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1265-75 |year= 2003 |pmid= 12598615 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Boll M, Foltz M, Rubio-Aliaga I, Daniel H |title=A cluster of proton/amino acid transporter genes in the human and mouse genomes. |journal=Genomics |volume=82 |issue= 1 |pages= 47-56 |year= 2004 |pmid= 12809675 |doi=  }}
+*{{cite journal  | vauthors=Bermingham JR, Pennington J |title=Organization and expression of the SLC36 cluster of amino acid transporter genes |journal=Mamm. Genome |volume=15 |issue= 2 |pages= 114–25 |year= 2004 |pmid= 15058382 |doi=10.1007/s00335-003-2319-3  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
-*{{cite journal  | author=Bermingham JR, Pennington J |title=Organization and expression of the SLC36 cluster of amino acid transporter genes. |journal=Mamm. Genome |volume=15 |issue= 2 |pages= 114-25 |year= 2004 |pmid= 15058382 |doi=  }}
+*{{cite journal   |vauthors=Anderson CM, Grenade DS, Boll M, etal |title=H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat |journal=Gastroenterology |volume=127 |issue= 5 |pages= 1410–22 |year= 2004 |pmid= 15521011 |doi=10.1053/j.gastro.2004.08.017  }}
-*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
+*{{cite journal  | vauthors=Anderson CM, Thwaites DT |title=Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1) |journal=J. Cell. Physiol. |volume=204 |issue= 2 |pages= 604–13 |year= 2005 |pmid= 15754324 |doi= 10.1002/jcp.20337 }}
-*{{cite journal  | author=Anderson CM, Grenade DS, Boll M, ''et al.'' |title=H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. |journal=Gastroenterology |volume=127 |issue= 5 |pages= 1410-22 |year= 2004 |pmid= 15521011 |doi=  }}
+*{{cite journal   |vauthors=Abbot EL, Grenade DS, Kennedy DJ, etal |title=Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1 |journal=Br. J. Pharmacol. |volume=147 |issue= 3 |pages= 298–306 |year= 2006 |pmid= 16331283 |doi= 10.1038/sj.bjp.0706557  | pmc=1751303 }}
-*{{cite journal  | author=Anderson CM, Thwaites DT |title=Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). |journal=J. Cell. Physiol. |volume=204 |issue= 2 |pages= 604-13 |year= 2005 |pmid= 15754324 |doi= 10.1002/jcp.20337 }}
+*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
-*{{cite journal  | author=Abbot EL, Grenade DS, Kennedy DJ, ''et al.'' |title=Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1. |journal=Br. J. Pharmacol. |volume=147 |issue= 3 |pages= 298-306 |year= 2006 |pmid= 16331283 |doi= 10.1038/sj.bjp.0706557 }}
+*{{cite journal   |vauthors=Kuan YH, Gruebl T, Soba P, etal |title=PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2 |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 40114–23 |year= 2007 |pmid= 17050537 |doi= 10.1074/jbc.M605407200 }}
-*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
-*{{cite journal  | author=Kuan YH, Gruebl T, Soba P, ''et al.'' |title=PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2. |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 40114-23 |year= 2007 |pmid= 17050537 |doi= 10.1074/jbc.M605407200 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Membrane transport proteins}}
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+{{PBB_Controls
+| update_page = yes
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+| update_protein_box = yes
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+| update_citations = yes
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 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC36A1: Difference between revisions

Latest revision as of 06:32, 11 September 2017

See also

References

Further reading

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