SLC38A3: Difference between revisions

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Revision as of 06:33, 11 September 2017

Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.^[1]^[2]^[3]

References

↑ Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH (Feb 2000). "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission". Cell. 99 (7): 769–80. doi:10.1016/S0092-8674(00)81674-8. PMID 10619430.
↑ Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V (Sep 2000). "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter". J Biol Chem. 275 (31): 23707–17. doi:10.1074/jbc.M002282200. PMID 10823827.
↑ "Entrez Gene: SLC38A3 solute carrier family 38, member 3".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Boehmer C, Okur F, Setiawan I, et al. (2003). "Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB". Biochem. Biophys. Res. Commun. 306 (1): 156–62. doi:10.1016/S0006-291X(03)00921-5. PMID 12788082.
Sidoryk M, Matyja E, Dybel A, et al. (2004). "Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas". NeuroReport. 15 (4): 575–8. doi:10.1097/00001756-200403220-00001. PMID 15094455.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kholodnyuk ID, Kozireva S, Kost-Alimova M, et al. (2006). "Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice". Int. J. Cancer. 119 (1): 99–107. doi:10.1002/ijc.21794. PMID 16432833.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.

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[pmid10619430-1] Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH (Feb 2000). "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission". Cell. 99 (7): 769–80. doi:10.1016/S0092-8674(00)81674-8. PMID 10619430.

[pmid10823827-2] Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V (Sep 2000). "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter". J Biol Chem. 275 (31): 23707–17. doi:10.1074/jbc.M002282200. PMID 10823827.

[entrez-3] "Entrez Gene: SLC38A3 solute carrier family 38, member 3".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Sodium-coupled neutral amino acid transporter 3''' is a [[protein]] that in humans is encoded by the ''SLC38A3'' [[gene]].<ref name="pmid10619430">{{cite journal | vauthors = Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH | author5-link = Jon Storm-Mathisen | title = Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission | journal = Cell | volume = 99 | issue = 7 | pages = 769–80 |date=Feb 2000 | pmid = 10619430 | pmc =  | doi =10.1016/S0092-8674(00)81674-8  }}</ref><ref name="pmid10823827">{{cite journal | vauthors = Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V | title = Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter | journal = J Biol Chem | volume = 275 | issue = 31 | pages = 23707–17 |date=Sep 2000 | pmid = 10823827 | pmc =  | doi = 10.1074/jbc.M002282200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC38A3 solute carrier family 38, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10991| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 38, member 3
- | HGNCid = 18044
- | Symbol = SLC38A3
- | AltSymbols =; G17; SN1
- | OMIM = 604437
- | ECnumber =
- | Homologene = 4983
- | MGIid = 1923507
-  | GeneAtlas_image1 = PBB_GE_SLC38A3_205972_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005290 |text = L-histidine transmembrane transporter activity}} {{GNF_GO|id=GO:0015171 |text = amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015180 |text = L-alanine transmembrane transporter activity}} {{GNF_GO|id=GO:0015182 |text = L-asparagine transmembrane transporter activity}} {{GNF_GO|id=GO:0015186 |text = L-glutamine transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015297 |text = antiporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
-  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0006867 |text = asparagine transport}} {{GNF_GO|id=GO:0006868 |text = glutamine transport}} {{GNF_GO|id=GO:0015808 |text = L-alanine transport}} {{GNF_GO|id=GO:0015817 |text = histidine transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10991
-    | Hs_Ensembl = ENSG00000188338
-    | Hs_RefseqProtein = NP_006832
-    | Hs_RefseqmRNA = NM_006841
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 50226637
-    | Hs_GenLoc_end = 50233404
-    | Hs_Uniprot = Q99624
-    | Mm_EntrezGene = 76257
-    | Mm_Ensembl = ENSMUSG00000010064
-    | Mm_RefseqmRNA = NM_023805
-    | Mm_RefseqProtein = NP_076294
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 107509262
-    | Mm_GenLoc_end = 107527069
-    | Mm_Uniprot = Q9DCP2
-  }}
-}}
-'''Solute carrier family 38, member 3''', also known as '''SLC38A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC38A3 solute carrier family 38, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10991| accessdate = }}</ref>
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 {{PBB_Summary
@@ Line 58: / Line 11: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 64: / Line 17: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Chaudhry FA, Reimer RJ, Krizaj D, ''et al.'' |title=Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. |journal=Cell |volume=99 |issue= 7 |pages= 769-80 |year= 2000 |pmid= 10619430 |doi=  }}
+*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
-*{{cite journal  | author=Fei YJ, Sugawara M, Nakanishi T, ''et al.'' |title=Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23707-17 |year= 2000 |pmid= 10823827 |doi= 10.1074/jbc.M002282200 }}
+*{{cite journal  | vauthors=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116–33 |year= 2000 |pmid= 11085536 |doi=  }}
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
-*{{cite journal  | author=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116-33 |year= 2000 |pmid= 11085536 |doi=  }}
+*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
+*{{cite journal   |vauthors=Boehmer C, Okur F, Setiawan I, etal |title=Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 156–62 |year= 2003 |pmid= 12788082 |doi=10.1016/S0006-291X(03)00921-5  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Sidoryk M, Matyja E, Dybel A, etal |title=Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. |journal=NeuroReport |volume=15 |issue= 4 |pages= 575–8 |year= 2004 |pmid= 15094455 |doi=10.1097/00001756-200403220-00001  }}
-*{{cite journal  | author=Boehmer C, Okur F, Setiawan I, ''et al.'' |title=Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 156-62 |year= 2003 |pmid= 12788082 |doi=  }}
+*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
-*{{cite journal  | author=Sidoryk M, Matyja E, Dybel A, ''et al.'' |title=Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. |journal=Neuroreport |volume=15 |issue= 4 |pages= 575-8 |year= 2004 |pmid= 15094455 |doi=  }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
+*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
-*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
+*{{cite journal   |vauthors=Kholodnyuk ID, Kozireva S, Kost-Alimova M, etal |title=Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. |journal=Int. J. Cancer |volume=119 |issue= 1 |pages= 99–107 |year= 2006 |pmid= 16432833 |doi= 10.1002/ijc.21794 }}
-*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
+*{{cite journal   |vauthors=Muzny DM, Scherer SE, Kaul R, etal |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
-*{{cite journal  | author=Kholodnyuk ID, Kozireva S, Kost-Alimova M, ''et al.'' |title=Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. |journal=Int. J. Cancer |volume=119 |issue= 1 |pages= 99-107 |year= 2006 |pmid= 16432833 |doi= 10.1002/ijc.21794 }}
-*{{cite journal  | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC38A3: Difference between revisions

Revision as of 06:33, 11 September 2017

See also

References

Further reading

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