SLC4A4: Difference between revisions

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Electrogenic sodium bicarbonate cotransporter 1 is a membrane transport protein that in humans is encoded by the SLC4A4 gene.^[1]^[2]^[3]

Function

Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM]^[3]

Clinical significance

NBCe1 may participate in regulation of brain extracellular space pH. Some mutations in NBCe1 have been associated with Familial hemiplegic migraine.^[4] Other NBCe1 mutations disrupt kidney bicarbonate transport and cause proximal renal tubular acidosis.^[5]

Splice variants

NBCe1-A aka kNBC1 (mainly expressed in the kidney)

NBCe1-B aka pNBC1 (expressed in the pancreas and elsewhere)

NBCe1-C (expressed in the brain)

Distribution

The renal SLC4A4 gene product NBCe1-A is specifically expressed in the basolateral membranes of proximal tubule epithelia.

References

↑ Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M (Aug 1997). "Cloning and functional expression of a human kidney Na+:HCO3- cotransporter". J Biol Chem. 272 (31): 19111–4. doi:10.1074/jbc.272.31.19111. PMID 9235899.
↑ Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, Kurtz I (Aug 1998). "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter". J Biol Chem. 273 (28): 17689–95. doi:10.1074/jbc.273.28.17689. PMID 9651366.
↑ ^3.0 ^3.1 "Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4".
↑ Suzuki M, Van Paesschen W, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, De Jonghe P, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shiohara M, Braverman N, Al-Gazali L, Fujita T, Seki G (September 2010). "Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine". Proc. Natl. Acad. Sci. U.S.A. 107 (36): 15963–8. doi:10.1073/pnas.1008705107. PMC 2936614. PMID 20798035.
↑ Zhu Q, Kao L, Azimov R, Newman D, Liu W, Pushkin A, Abuladze N, Kurtz I (April 2010). "Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis". J. Biol. Chem. 285 (18): 13416–26. doi:10.1074/jbc.M109.093286. PMC 2859501. PMID 20197274.

Romero MF, Boron WF (1999). "Electrogenic Na+/HCO3- cotransporters: cloning and physiology". Annu. Rev. Physiol. 61: 699–723. doi:10.1146/annurev.physiol.61.1.699. PMID 10099707.
Soleimani M, Burnham CE (2000). "Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes". Kidney Int. 57 (2): 371–84. doi:10.1046/j.1523-1755.2000.00857.x. PMID 10652014.
Choi I, Romero MF, Khandoudi N, et al. (1999). "Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)". Am. J. Physiol. 276 (3 Pt 1): C576–84. PMID 10069984.
Igarashi T, Inatomi J, Sekine T, et al. (1999). "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities". Nat. Genet. 23 (3): 264–6. doi:10.1038/15440. PMID 10545938.
Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. PMID 10600945.
Park K, Hurley PT, Roussa E, et al. (2002). "Expression of a sodium bicarbonate cotransporter in human parotid salivary glands". Arch. Oral Biol. 47 (1): 1–9. doi:10.1016/S0003-9969(01)00098-X. PMID 11743927.
Gross E, Hawkins K, Pushkin A, et al. (2002). "Phosphorylation of Ser982 in the sodium bicarbonate cotransporter kNBC1 shifts the HCO3−: Na+ stoichiometry from 3:1 to 2:1 in murine proximal tubule cells". J. Physiol. 537 (Pt 3): 659–65. doi:10.1113/jphysiol.2001.012956. PMC 2278987. PMID 11744745.
Gross E, Pushkin A, Abuladze N, et al. (2003). "Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp986, Asp988 and kNBC1-carbonic anhydrase II binding". J. Physiol. 544 (Pt 3): 679–85. doi:10.1113/jphysiol.2002.029777. PMC 2290621. PMID 12411514.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tatishchev S, Abuladze N, Pushkin A, et al. (2003). "Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation". Biochemistry. 42 (3): 755–65. doi:10.1021/bi026826q. PMID 12534288.
Gross E, Fedotoff O, Pushkin A, et al. (2004). "Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini". J. Physiol. 549 (Pt 3): 673–82. doi:10.1113/jphysiol.2003.042226. PMC 2342979. PMID 12730338.
Sun XC, Bonanno JA (2003). "Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium". Exp. Eye Res. 77 (3): 287–95. doi:10.1016/S0014-4835(03)00150-7. PMID 12907161.
Yamada H, Yamazaki S, Moriyama N, et al. (2003). "Localization of NBC-1 variants in human kidney and renal cell carcinoma". Biochem. Biophys. Res. Commun. 310 (4): 1213–8. doi:10.1016/j.bbrc.2003.09.147. PMID 14559244.
Alvarez BV, Loiselle FB, Supuran CT, et al. (2003). "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter". Biochemistry. 42 (42): 12321–9. doi:10.1021/bi0353124. PMID 14567693.
Becker HM, Deitmer JW (2004). "Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes". J. Biol. Chem. 279 (27): 28057–62. doi:10.1074/jbc.M402401200. PMID 15123668.
Pushkin A, Abuladze N, Gross E, et al. (2005). "Molecular mechanism of kNBC1—carbonic anhydrase II interaction in proximal tubule cells". J. Physiol. 559 (Pt 1): 55–65. doi:10.1113/jphysiol.2004.065110. PMC 1665076. PMID 15218065.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid9235899-1] Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M (Aug 1997). "Cloning and functional expression of a human kidney Na+:HCO3- cotransporter". J Biol Chem. 272 (31): 19111–4. doi:10.1074/jbc.272.31.19111. PMID 9235899.

[pmid9651366-2] Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, Kurtz I (Aug 1998). "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter". J Biol Chem. 273 (28): 17689–95. doi:10.1074/jbc.273.28.17689. PMID 9651366.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4".

[pmid20798035-4] Suzuki M, Van Paesschen W, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, De Jonghe P, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shiohara M, Braverman N, Al-Gazali L, Fujita T, Seki G (September 2010). "Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine". Proc. Natl. Acad. Sci. U.S.A. 107 (36): 15963–8. doi:10.1073/pnas.1008705107. PMC 2936614. PMID 20798035.

[pmid20197274-5] Zhu Q, Kao L, Azimov R, Newman D, Liu W, Pushkin A, Abuladze N, Kurtz I (April 2010). "Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis". J. Biol. Chem. 285 (18): 13416–26. doi:10.1074/jbc.M109.093286. PMC 2859501. PMID 20197274.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Electrogenic sodium bicarbonate cotransporter 1''' is a [[membrane transport protein]] that in humans is encoded by the ''SLC4A4'' [[gene]].<ref name="pmid9235899">{{cite journal | vauthors = Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M | title = Cloning and functional expression of a human kidney Na+:HCO3- cotransporter | journal = J Biol Chem | volume = 272 | issue = 31 | pages = 19111–4 |date=Aug 1997 | pmid = 9235899 | pmc =  | doi =10.1074/jbc.272.31.19111  }}</ref><ref name="pmid9651366">{{cite journal | vauthors = Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, Kurtz I | title = Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter | journal = J Biol Chem | volume = 273 | issue = 28 | pages = 17689–95 |date=Aug 1998 | pmid = 9651366 | pmc =  | doi =10.1074/jbc.273.28.17689  }}</ref><ref name="entrez"/>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 4, sodium bicarbonate cotransporter, member 4
- | HGNCid = 11030
- | Symbol = SLC4A4
- | AltSymbols =; DKFZp781H1314; HNBC1; KNBC; NBC1; NBC2; SLC4A5; hhNMC; pNBC
- | OMIM = 603345
- | ECnumber =
- | Homologene = 55776
- | MGIid = 1927555
- | GeneAtlas_image1 = PBB_GE_SLC4A4_203908_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC4A4_210738_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_SLC4A4_210739_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0005452 |text = inorganic anion exchanger activity}} {{GNF_GO|id=GO:0008510 |text = sodium:bicarbonate symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006820 |text = anion transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8671
-    | Hs_Ensembl = ENSG00000080493
-    | Hs_RefseqProtein = NP_003750
-    | Hs_RefseqmRNA = NM_003759
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 72271867
-    | Hs_GenLoc_end = 72656663
-    | Hs_Uniprot = Q9Y6R1
-    | Mm_EntrezGene = 54403
-    | Mm_Ensembl = ENSMUSG00000060961
-    | Mm_RefseqmRNA = NM_018760
-    | Mm_RefseqProtein = NP_061230
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 90009311
-    | Mm_GenLoc_end = 90310338
-    | Mm_Uniprot = O88343
-  }}
-}}
-'''Solute carrier family 4, sodium bicarbonate cotransporter, member 4''', also known as '''SLC4A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+Sodium bicarbonate [[cotransporter]]s (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate [[Co-transport|cotransport]] is involved in bicarbonate secretion/absorption and [[intracellular pH]] regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text = Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = }}</ref>
-}}
-==See also==
+== Clinical significance ==
+NBCe1 may participate in regulation of brain [[extracellular space]] [[pH]]. Some mutations in NBCe1 have been associated with [[Familial hemiplegic migraine]].<ref name="pmid20798035">{{cite journal | vauthors = Suzuki M, Van Paesschen W, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, De Jonghe P, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shiohara M, Braverman N, Al-Gazali L, Fujita T, Seki G | title = Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 107 | issue = 36 | pages = 15963–8 |date=September 2010 | pmid = 20798035 | pmc = 2936614 | doi = 10.1073/pnas.1008705107 }}</ref> Other NBCe1 mutations disrupt kidney bicarbonate transport and cause [[proximal renal tubular acidosis]].<ref name="pmid20197274">{{cite journal | vauthors = Zhu Q, Kao L, Azimov R, Newman D, Liu W, Pushkin A, Abuladze N, Kurtz I | title = Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis | journal = J. Biol. Chem. | volume = 285 | issue = 18 | pages = 13416–26 |date=April 2010 | pmid = 20197274 | pmc = 2859501 | doi = 10.1074/jbc.M109.093286 }}</ref>
+==[[Splice variant]]s==
+NBCe1-A aka kNBC1 (mainly expressed in the kidney)
+NBCe1-B aka pNBC1 (expressed in the pancreas and elsewhere)
+NBCe1-C (expressed in the brain)
+== Distribution ==
+The renal SLC4A4 gene product NBCe1-A is specifically expressed in the basolateral membranes of proximal tubule epithelia.
+== See also ==
 * [[Solute carrier family]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Romero MF, Boron WF |title=Electrogenic Na+/HCO3- cotransporters: cloning and physiology. |journal=Annu. Rev. Physiol. |volume=61 |issue=  |pages= 699–723 |year= 1999 |pmid= 10099707 |doi= 10.1146/annurev.physiol.61.1.699 }}
-| citations =
+*{{cite journal  | vauthors=Soleimani M, Burnham CE |title=Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes. |journal=Kidney Int. |volume=57 |issue= 2 |pages= 371–84 |year= 2000 |pmid= 10652014 |doi= 10.1046/j.1523-1755.2000.00857.x }}
-*{{cite journal  | author=Romero MF, Boron WF |title=Electrogenic Na+/HCO3- cotransporters: cloning and physiology. |journal=Annu. Rev. Physiol. |volume=61 |issue=  |pages= 699-723 |year= 1999 |pmid= 10099707 |doi= 10.1146/annurev.physiol.61.1.699 }}
+*{{cite journal   |vauthors=Choi I, Romero MF, Khandoudi N, etal |title=Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC). |journal=Am. J. Physiol. |volume=276 |issue= 3 Pt 1 |pages= C576–84 |year= 1999 |pmid= 10069984 |doi=  }}
-*{{cite journal  | author=Soleimani M, Burnham CE |title=Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes. |journal=Kidney Int. |volume=57 |issue= 2 |pages= 371-84 |year= 2000 |pmid= 10652014 |doi= 10.1046/j.1523-1755.2000.00857.x }}
+*{{cite journal   |vauthors=Igarashi T, Inatomi J, Sekine T, etal |title=Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 264–6 |year= 1999 |pmid= 10545938 |doi= 10.1038/15440 }}
-*{{cite journal  | author=Burnham CE, Amlal H, Wang Z, ''et al.'' |title=Cloning and functional expression of a human kidney Na+:HCO3- cotransporter. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19111-4 |year= 1997 |pmid= 9235899 |doi=  }}
+*{{cite journal   |vauthors=Pushkin A, Yip KP, Clark I, etal |title=NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 2 |pages= F974–81 |year= 2000 |pmid= 10600945 |doi=  }}
-*{{cite journal  | author=Abuladze N, Lee I, Newman D, ''et al.'' |title=Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17689-95 |year= 1998 |pmid= 9651366 |doi=  }}
+*{{cite journal   |vauthors=Park K, Hurley PT, Roussa E, etal |title=Expression of a sodium bicarbonate cotransporter in human parotid salivary glands. |journal=Arch. Oral Biol. |volume=47 |issue= 1 |pages= 1–9 |year= 2002 |pmid= 11743927 |doi=10.1016/S0003-9969(01)00098-X  }}
-*{{cite journal  | author=Choi I, Romero MF, Khandoudi N, ''et al.'' |title=Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC). |journal=Am. J. Physiol. |volume=276 |issue= 3 Pt 1 |pages= C576-84 |year= 1999 |pmid= 10069984 |doi=  }}
+*{{cite journal   |vauthors=Gross E, Hawkins K, Pushkin A, etal |title=Phosphorylation of Ser982 in the sodium bicarbonate cotransporter kNBC1 shifts the HCO3−: Na+ stoichiometry from 3:1 to 2:1 in murine proximal tubule cells |journal=J. Physiol. |volume=537 |issue= Pt 3 |pages= 659–65 |year= 2002 |pmid= 11744745 |doi=10.1113/jphysiol.2001.012956  | pmc=2278987  }}
-*{{cite journal  | author=Igarashi T, Inatomi J, Sekine T, ''et al.'' |title=Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 264-6 |year= 1999 |pmid= 10545938 |doi= 10.1038/15440 }}
+*{{cite journal   |vauthors=Gross E, Pushkin A, Abuladze N, etal |title=Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp986, Asp988 and kNBC1-carbonic anhydrase II binding |journal=J. Physiol. |volume=544 |issue= Pt 3 |pages= 679–85 |year= 2003 |pmid= 12411514 |doi=10.1113/jphysiol.2002.029777  | pmc=2290621  }}
-*{{cite journal  | author=Pushkin A, Yip KP, Clark I, ''et al.'' |title=NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 2 |pages= F974-81 |year= 2000 |pmid= 10600945 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Park K, Hurley PT, Roussa E, ''et al.'' |title=Expression of a sodium bicarbonate cotransporter in human parotid salivary glands. |journal=Arch. Oral Biol. |volume=47 |issue= 1 |pages= 1-9 |year= 2002 |pmid= 11743927 |doi=  }}
+*{{cite journal   |vauthors=Tatishchev S, Abuladze N, Pushkin A, etal |title=Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation |journal=Biochemistry |volume=42 |issue= 3 |pages= 755–65 |year= 2003 |pmid= 12534288 |doi= 10.1021/bi026826q }}
-*{{cite journal  | author=Gross E, Hawkins K, Pushkin A, ''et al.'' |title=Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells. |journal=J. Physiol. (Lond.) |volume=537 |issue= Pt 3 |pages= 659-65 |year= 2002 |pmid= 11744745 |doi=  }}
+*{{cite journal   |vauthors=Gross E, Fedotoff O, Pushkin A, etal |title=Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini |journal=J. Physiol. |volume=549 |issue= Pt 3 |pages= 673–82 |year= 2004 |pmid= 12730338 |doi= 10.1113/jphysiol.2003.042226  | pmc=2342979 }}
-*{{cite journal  | author=Gross E, Pushkin A, Abuladze N, ''et al.'' |title=Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding. |journal=J. Physiol. (Lond.) |volume=544 |issue= Pt 3 |pages= 679-85 |year= 2003 |pmid= 12411514 |doi=  }}
+*{{cite journal  | vauthors=Sun XC, Bonanno JA |title=Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium |journal=Exp. Eye Res. |volume=77 |issue= 3 |pages= 287–95 |year= 2003 |pmid= 12907161 |doi=10.1016/S0014-4835(03)00150-7  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Yamada H, Yamazaki S, Moriyama N, etal |title=Localization of NBC-1 variants in human kidney and renal cell carcinoma |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1213–8 |year= 2003 |pmid= 14559244 |doi=10.1016/j.bbrc.2003.09.147  }}
-*{{cite journal  | author=Tatishchev S, Abuladze N, Pushkin A, ''et al.'' |title=Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation. |journal=Biochemistry |volume=42 |issue= 3 |pages= 755-65 |year= 2003 |pmid= 12534288 |doi= 10.1021/bi026826q }}
+*{{cite journal   |vauthors=Alvarez BV, Loiselle FB, Supuran CT, etal |title=Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter |journal=Biochemistry |volume=42 |issue= 42 |pages= 12321–9 |year= 2003 |pmid= 14567693 |doi= 10.1021/bi0353124 }}
-*{{cite journal  | author=Gross E, Fedotoff O, Pushkin A, ''et al.'' |title=Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. |journal=J. Physiol. (Lond.) |volume=549 |issue= Pt 3 |pages= 673-82 |year= 2004 |pmid= 12730338 |doi= 10.1113/jphysiol.2003.042226 }}
+*{{cite journal  | vauthors=Becker HM, Deitmer JW |title=Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28057–62 |year= 2004 |pmid= 15123668 |doi= 10.1074/jbc.M402401200 }}
-*{{cite journal  | author=Sun XC, Bonanno JA |title=Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium. |journal=Exp. Eye Res. |volume=77 |issue= 3 |pages= 287-95 |year= 2003 |pmid= 12907161 |doi=  }}
+*{{cite journal   |vauthors=Pushkin A, Abuladze N, Gross E, etal |title=Molecular mechanism of kNBC1—carbonic anhydrase II interaction in proximal tubule cells |journal=J. Physiol. |volume=559 |issue= Pt 1 |pages= 55–65 |year= 2005 |pmid= 15218065 |doi= 10.1113/jphysiol.2004.065110  | pmc=1665076 }}
-*{{cite journal  | author=Yamada H, Yamazaki S, Moriyama N, ''et al.'' |title=Localization of NBC-1 variants in human kidney and renal cell carcinoma. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1213-8 |year= 2003 |pmid= 14559244 |doi=  }}
-*{{cite journal  | author=Alvarez BV, Loiselle FB, Supuran CT, ''et al.'' |title=Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12321-9 |year= 2003 |pmid= 14567693 |doi= 10.1021/bi0353124 }}
-*{{cite journal  | author=Becker HM, Deitmer JW |title=Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28057-62 |year= 2004 |pmid= 15123668 |doi= 10.1074/jbc.M402401200 }}
-*{{cite journal  | author=Pushkin A, Abuladze N, Gross E, ''et al.'' |title=Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. |journal=J. Physiol. (Lond.) |volume=559 |issue= Pt 1 |pages= 55-65 |year= 2005 |pmid= 15218065 |doi= 10.1113/jphysiol.2004.065110 }}
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+[[Category:Solute carrier family]]
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-{{Membrane transport proteins}}
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-{{WikiDoc Sources}}

SLC4A4: Difference between revisions

Revision as of 06:34, 11 September 2017

Contents

Function

Clinical significance

Splice variants

Distribution

See also

References

Further reading

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