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{{Infobox_gene}}
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'''Cationic amino acid transporter 3''' is a [[protein]] that in humans is encoded by the ''SLC7A3'' [[gene]].<ref name="pmid11591158">{{cite journal | vauthors = Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI | title = Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues | journal = Biochemistry | volume = 40 | issue = 41 | pages = 12387–94 |date=Oct 2001 | pmid = 11591158 | pmc =  | doi =10.1021/bi011345c }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84889| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
| HGNCid = 11061
| Symbol = SLC7A3
| AltSymbols =; ATRC3; CAT-3; FLJ14541; MGC20687
| OMIM = 300443
| ECnumber = 
| Homologene = 56382
| MGIid = 1100521
| Function = {{GNF_GO|id=GO:0015181 |text = arginine transmembrane transporter activity}} {{GNF_GO|id=GO:0015189 |text = L-lysine transmembrane transporter activity}} {{GNF_GO|id=GO:0015326 |text = cationic amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015359 |text = amino acid transmembrane transporter activity}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0015809 |text = arginine transport}} {{GNF_GO|id=GO:0015819 |text = lysine transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84889
    | Hs_Ensembl = ENSG00000165349
    | Hs_RefseqProtein = NP_001041629
    | Hs_RefseqmRNA = NM_001048164
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 70062157
    | Hs_GenLoc_end = 70067700
    | Hs_Uniprot = Q8WY07
    | Mm_EntrezGene = 11989
    | Mm_Ensembl = ENSMUSG00000031297
    | Mm_RefseqmRNA = NM_007515
    | Mm_RefseqProtein = NP_031541
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 97281940
    | Mm_GenLoc_end = 97288093
    | Mm_Uniprot = Q3TMH5
  }}
}}
'''Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3''', also known as '''SLC7A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84889| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84889| accessdate = }}</ref>
| summary_text = SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84889| accessdate = }}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Hosokawa H, Sawamura T, Kobayashi S, ''et al.'' |title=Cloning and characterization of a brain-specific cationic amino acid transporter. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8717-22 |year= 1997 |pmid= 9079705 |doi=  }}
*{{cite journal   |vauthors=Hosokawa H, Sawamura T, Kobayashi S, etal |title=Cloning and characterization of a brain-specific cationic amino acid transporter. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8717–22 |year= 1997 |pmid= 9079705 |doi=10.1074/jbc.272.13.8717 }}
*{{cite journal  | author=Ito K, Groudine M |title=A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26780-6 |year= 1997 |pmid= 9334265 |doi=  }}
*{{cite journal  | vauthors=Ito K, Groudine M |title=A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26780–6 |year= 1997 |pmid= 9334265 |doi=10.1074/jbc.272.42.26780 }}
*{{cite journal | author=Hosokawa H, Ninomiya H, Sawamura T, ''et al.'' |title=Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain. |journal=Brain Res. |volume=838 |issue= 1-2 |pages= 158-65 |year= 1999 |pmid= 10446328 |doi= }}
*{{cite journal   |vauthors=Hosokawa H, Ninomiya H, Sawamura T, etal |title=Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain. |journal=Brain Res. |volume=838 |issue= 1-2 |pages= 158–65 |year= 1999 |pmid= 10446328 |doi=10.1016/S0006-8993(99)01686-8 }}
*{{cite journal  | author=Vékony N, Wolf S, Boissel JP, ''et al.'' |title=Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues. |journal=Biochemistry |volume=40 |issue= 41 |pages= 12387-94 |year= 2001 |pmid= 11591158 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gilles W, Vulcu SD, Liewald JF, etal |title=Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3. |journal=Biochim. Biophys. Acta |volume=1668 |issue= 2 |pages= 234–9 |year= 2005 |pmid= 15737334 |doi= 10.1016/j.bbamem.2004.12.011 }}
*{{cite journal | author=Gilles W, Vulcu SD, Liewald JF, ''et al.'' |title=Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3. |journal=Biochim. Biophys. Acta |volume=1668 |issue= 2 |pages= 234-9 |year= 2005 |pmid= 15737334 |doi= 10.1016/j.bbamem.2004.12.011 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Rotmann A, Vékony N, Gassner D, etal |title=Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane. |journal=Biochem. J. |volume=395 |issue= 1 |pages= 117–23 |year= 2006 |pmid= 16332251 |doi= 10.1042/BJ20051558 | pmc=1409692 }}
*{{cite journal | author=Rotmann A, Vékony N, Gassner D, ''et al.'' |title=Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane. |journal=Biochem. J. |volume=395 |issue= 1 |pages= 117-23 |year= 2006 |pmid= 16332251 |doi= 10.1042/BJ20051558 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
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Revision as of 06:36, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.[1][2]

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM][2]

See also

References

  1. ↑ Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues". Biochemistry. 40 (41): 12387–94. doi:10.1021/bi011345c. PMID 11591158.
  2. ↑ 2.0 2.1 "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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