UBE2B: Difference between revisions

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Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.^[1]^[2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.^[2]

Interactions

UBE2B has been shown to interact with RAD18.^[3]^[4]

References

↑ Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696.
↑ ^2.0 ^2.1 "Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)".
↑ Xin, H; Lin W; Sumanasekera W; Zhang Y; Wu X; Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. ENGLAND. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344.
↑ Tateishi, S; Sakuraba Y; Masuyama S; Inoue H; Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647. PMID 10884424.

Koken MH, Reynolds P, Jaspers-Dekker I, et al. (1991). "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 8865–9. doi:10.1073/pnas.88.20.8865. PMC 52611. PMID 1717990.
Woffendin C, Chen ZY, Staskus K, et al. (1991). "Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6". Biochim. Biophys. Acta. 1090 (1): 81–5. doi:10.1016/0167-4781(91)90039-o. PMID 1883845.
Schneider R, Eckerskorn C, Lottspeich F, Schweiger M (1990). "The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6". EMBO J. 9 (5): 1431–5. PMC 551831. PMID 2158443.
Koken MH, Hoogerbrugge JW, Jasper-Dekker I, et al. (1996). "Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification". Dev. Biol. 173 (1): 119–32. doi:10.1006/dbio.1996.0011. PMID 8575614.
Tateishi S, Sakuraba Y, Masuyama S, et al. (2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. PMC 16647. PMID 10884424.
Xin H, Lin W, Sumanasekera W, et al. (2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344.
Miura T, Klaus W, Ross A, et al. (2003). "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b". J. Biomol. NMR. 22 (1): 89–92. doi:10.1023/A:1013807519703. PMID 11885984.
Shekhar MP, Lyakhovich A, Visscher DW, et al. (2002). "Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation". Cancer Res. 62 (7): 2115–24. PMID 11929833.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kwon YT, Xia Z, An JY, et al. (2003). "Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway". Mol. Cell. Biol. 23 (22): 8255–71. doi:10.1128/MCB.23.22.8255-8271.2003. PMC 262401. PMID 14585983.
Lyakhovich A, Shekhar MP (2004). "RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response". Oncogene. 23 (17): 3097–106. doi:10.1038/sj.onc.1207449. PMID 14981545.
Watanabe K, Tateishi S, Kawasuji M, et al. (2005). "Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination". EMBO J. 23 (19): 3886–96. doi:10.1038/sj.emboj.7600383. PMC 522788. PMID 15359278.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Shekhar MP, Tait L, Gerard B (2007). "Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells". Mol. Cancer Res. 4 (10): 729–45. doi:10.1158/1541-7786.MCR-06-0136. PMID 17050667.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[pmid1559696-1] Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696.

[entrez-2] 2.0 ^2.1 "Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)".

[pmid10908344-3] Xin, H; Lin W; Sumanasekera W; Zhang Y; Wu X; Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. ENGLAND. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344.

[pmid10884424-4] Tateishi, S; Sakuraba Y; Masuyama S; Inoue H; Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647. PMID 10884424.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Ubiquitin-conjugating enzyme E2 B''' is a [[protein]] that in humans is encoded by the ''UBE2B'' [[gene]].<ref name="pmid1559696">{{cite journal |vauthors=Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH | title = Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31 | journal = Genomics | volume = 12 | issue = 3 | pages = 447–53 |date=May 1992 | pmid = 1559696 | pmc =  | doi =10.1016/0888-7543(92)90433-S  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = }}</ref>
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_UBE2B_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jas.
- | PDB = {{PDB2|1jas}}
- | Name = Ubiquitin-conjugating enzyme E2B (RAD6 homolog)
- | HGNCid = 12473
- | Symbol = UBE2B
- | AltSymbols =; UBC2; E2-17kDa; HHR6B; HR6B; RAD6B
- | OMIM = 179095
- | ECnumber =
- | Homologene = 37761
- | MGIid = 102944
- | GeneAtlas_image1 = PBB_GE_UBE2B_202334_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_UBE2B_202333_s_at_tn.png
-  | GeneAtlas_image3 = PBB_GE_UBE2B_202335_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
- | Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006301 |text = postreplication repair}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007288 |text = sperm axoneme assembly}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7320
-    | Hs_Ensembl = ENSG00000119048
-    | Hs_RefseqProtein = NP_003328
-    | Hs_RefseqmRNA = NM_003337
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 133734769
-    | Hs_GenLoc_end = 133755698
-    | Hs_Uniprot = P63146
-    | Mm_EntrezGene = 22210
-    | Mm_Ensembl = ENSMUSG00000020390
-    | Mm_RefseqmRNA = NM_009458
-    | Mm_RefseqProtein = NP_033484
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 51828985
-    | Mm_GenLoc_end = 51843810
-    | Mm_Uniprot = P63147
-  }}
-}}
-'''Ubiquitin-conjugating enzyme E2B (RAD6 homolog)''', also known as '''UBE2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.<ref name="entrez">{{cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = }}</ref>
+| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.<ref name="entrez"/>
 }}
+==Interactions==
+UBE2B has been shown to [[Protein-protein interaction|interact]] with [[RAD18]].<ref name=pmid10908344>{{cite journal |doi=10.1093/nar/28.14.2847 |last=Xin |first=H |authorlink= |author2=Lin W |author3=Sumanasekera W |author4=Zhang Y |author5=Wu X |author6=Wang Z  |date=July 2000  |title=The human RAD18 gene product interacts with HHR6A and HHR6B |journal=Nucleic Acids Res. |volume=28 |issue=14 |pages=2847–54 |publisher= |location = ENGLAND| issn = | pmid = 10908344 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=102657 }}</ref><ref name=pmid10884424>{{cite journal |doi=10.1073/pnas.97.14.7927 |last=Tateishi |first=S |authorlink= |author2=Sakuraba Y |author3=Masuyama S |author4=Inoue H |author5=Yamaizumi M  |date=July 2000  |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=14 |pages=7927–32 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10884424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16647 }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Koken MH, Smit EM, Jaspers-Dekker I, ''et al.'' |title=Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. |journal=Genomics |volume=12 |issue= 3 |pages= 447-53 |year= 1992 |pmid= 1559696 |doi=  }}
+*{{cite journal   |vauthors=Koken MH, Reynolds P, Jaspers-Dekker I, etal |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865–9 |year= 1991 |pmid= 1717990 |doi=10.1073/pnas.88.20.8865  | pmc=52611  }}
-*{{cite journal  | author=Koken MH, Reynolds P, Jaspers-Dekker I, ''et al.'' |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865-9 |year= 1991 |pmid= 1717990 |doi=  }}
+*{{cite journal   |vauthors=Woffendin C, Chen ZY, Staskus K, etal |title=Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6. |journal=Biochim. Biophys. Acta |volume=1090 |issue= 1 |pages= 81–5 |year= 1991 |pmid= 1883845 |doi=  10.1016/0167-4781(91)90039-o}}
-*{{cite journal  | author=Woffendin C, Chen ZY, Staskus K, ''et al.'' |title=Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6. |journal=Biochim. Biophys. Acta |volume=1090 |issue= 1 |pages= 81-5 |year= 1991 |pmid= 1883845 |doi=  }}
+*{{cite journal  |vauthors=Schneider R, Eckerskorn C, Lottspeich F, Schweiger M |title=The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. |journal=EMBO J. |volume=9 |issue= 5 |pages= 1431–5 |year= 1990 |pmid= 2158443 |doi=  | pmc=551831  }}
-*{{cite journal  | author=Schneider R, Eckerskorn C, Lottspeich F, Schweiger M |title=The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. |journal=EMBO J. |volume=9 |issue= 5 |pages= 1431-5 |year= 1990 |pmid= 2158443 |doi=  }}
+*{{cite journal   |vauthors=Koken MH, Hoogerbrugge JW, Jasper-Dekker I, etal |title=Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. |journal=Dev. Biol. |volume=173 |issue= 1 |pages= 119–32 |year= 1996 |pmid= 8575614 |doi=10.1006/dbio.1996.0011  }}
-*{{cite journal  | author=Koken MH, Hoogerbrugge JW, Jasper-Dekker I, ''et al.'' |title=Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. |journal=Dev. Biol. |volume=173 |issue= 1 |pages= 119-32 |year= 1996 |pmid= 8575614 |doi=  }}
+*{{cite journal   |vauthors=Tateishi S, Sakuraba Y, Masuyama S, etal |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927–32 |year= 2000 |pmid= 10884424 |doi=10.1073/pnas.97.14.7927  | pmc=16647  }}
-*{{cite journal  | author=Tateishi S, Sakuraba Y, Masuyama S, ''et al.'' |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927-32 |year= 2000 |pmid= 10884424 |doi=  }}
+*{{cite journal   |vauthors=Xin H, Lin W, Sumanasekera W, etal |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847–54 |year= 2000 |pmid= 10908344 |doi=10.1093/nar/28.14.2847  | pmc=102657  }}
-*{{cite journal  | author=Xin H, Lin W, Sumanasekera W, ''et al.'' |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847-54 |year= 2000 |pmid= 10908344 |doi=  }}
+*{{cite journal   |vauthors=Miura T, Klaus W, Ross A, etal |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89–92 |year= 2003 |pmid= 11885984 |doi=10.1023/A:1013807519703  }}
-*{{cite journal  | author=Miura T, Klaus W, Ross A, ''et al.'' |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89-92 |year= 2003 |pmid= 11885984 |doi=  }}
+*{{cite journal   |vauthors=Shekhar MP, Lyakhovich A, Visscher DW, etal |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115–24 |year= 2002 |pmid= 11929833 |doi=  }}
-*{{cite journal  | author=Shekhar MP, Lyakhovich A, Visscher DW, ''et al.'' |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115-24 |year= 2002 |pmid= 11929833 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Kwon YT, Xia Z, An JY, etal |title=Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8255–71 |year= 2003 |pmid= 14585983 |doi=10.1128/MCB.23.22.8255-8271.2003  | pmc=262401  }}
-*{{cite journal  | author=Kwon YT, Xia Z, An JY, ''et al.'' |title=Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8255-71 |year= 2003 |pmid= 14585983 |doi=  }}
+*{{cite journal  |vauthors=Lyakhovich A, Shekhar MP |title=RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. |journal=Oncogene |volume=23 |issue= 17 |pages= 3097–106 |year= 2004 |pmid= 14981545 |doi= 10.1038/sj.onc.1207449 }}
-*{{cite journal  | author=Lyakhovich A, Shekhar MP |title=RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. |journal=Oncogene |volume=23 |issue= 17 |pages= 3097-106 |year= 2004 |pmid= 14981545 |doi= 10.1038/sj.onc.1207449 }}
+*{{cite journal   |vauthors=Watanabe K, Tateishi S, Kawasuji M, etal |title=Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3886–96 |year= 2005 |pmid= 15359278 |doi= 10.1038/sj.emboj.7600383  | pmc=522788 }}
-*{{cite journal  | author=Watanabe K, Tateishi S, Kawasuji M, ''et al.'' |title=Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3886-96 |year= 2005 |pmid= 15359278 |doi= 10.1038/sj.emboj.7600383 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
-*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
+*{{cite journal  |vauthors=Shekhar MP, Tait L, Gerard B |title=Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. |journal=Mol. Cancer Res. |volume=4 |issue= 10 |pages= 729–45 |year= 2007 |pmid= 17050667 |doi= 10.1158/1541-7786.MCR-06-0136 }}
-*{{cite journal  | author=Shekhar MP, Tait L, Gerard B |title=Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. |journal=Mol. Cancer Res. |volume=4 |issue= 10 |pages= 729-45 |year= 2007 |pmid= 17050667 |doi= 10.1158/1541-7786.MCR-06-0136 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=7320}}
+{{Ubiquitin-conjugating enzymes}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-5-stub}}
-{{WikiDoc Sources}}

UBE2B: Difference between revisions

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