Follicular lymphoma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

Laboratory findings consistent with the diagnosis of follicular lymphoma includes

• Histological confirmation by centroblasts and centrocytes.
• Immunophenotyping using flow cytometry to detect immunophenotypes like CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1-, CD10-, BCL2- and BCL6+
• Immunohistochemistry for Ki-67,Aggressive clinical behavior is in association with low-grade follicular lymphoma with a high proliferation index. ( determined by Ki-67 immunostaining)
• Molecular genetic analysis for BCL2 rearrangement
• Cytogenetics or FISH for t(14;18)