Chondrosarcoma classification: Difference between revisions
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==Classification== | ==Classification== | ||
Chondrosarcoma is classified into six "subtypes" based on: | Chondrosarcoma is classified into six "subtypes" based on: | ||
(a) The topographical location of the tumor. | (a) The topographical location of the tumor. | ||
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*Dedifferentiated chondrosarcoma | *Dedifferentiated chondrosarcoma | ||
==Grading== | |||
Physicians grade chondrosarcoma using several criteria, but particularly on how abnormal the cancerous cells appear under the microscope and the growth rate of the tumors themselves, both of which are directly linked to the propensity of the cancer to invade locally, and to spread widely to distant organs and sites in the body (called [[metastasis]]). | Physicians grade chondrosarcoma using several criteria, but particularly on how abnormal the cancerous cells appear under the microscope and the growth rate of the tumors themselves, both of which are directly linked to the propensity of the cancer to invade locally, and to spread widely to distant organs and sites in the body (called [[metastasis]]). | ||
Revision as of 14:54, 31 August 2015
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Chondrosarcoma Microchapters |
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Chondrosarcoma classification On the Web |
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American Roentgen Ray Society Images of Chondrosarcoma classification |
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Risk calculators and risk factors for Chondrosarcoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Classification
Chondrosarcoma is classified into six "subtypes" based on: (a) The topographical location of the tumor. (b) The histological characteristics of the cancerous cartilage cells. (c) The makeup of the surrounding matrix material associated with the tumor.
- Chondrosarcoma NOS ("Not Otherwise Specified")
- Juxtacortical chondrosarcoma
- Myxoid chondrosarcoma
- Mesenchymal chondrosarcoma
- Clear cell chondrosarcoma
- Dedifferentiated chondrosarcoma
Grading
Physicians grade chondrosarcoma using several criteria, but particularly on how abnormal the cancerous cells appear under the microscope and the growth rate of the tumors themselves, both of which are directly linked to the propensity of the cancer to invade locally, and to spread widely to distant organs and sites in the body (called metastasis).
Grade 1
- Chondrosarcoma grows relatively slowly, has cells whose histological appearance is quite similar to cells of normal cartilage.
- Mostly chondroid matrix, little if any myxoid.
- Mild-to-moderate increase of cellularity +/- binucleated cells.
- Have much less aggressive invasive and metastatic properties.
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Grade 2
- Intermediate grade chondrosarcoma.
- Little chondroid matrix, Necrosis and more common prominent myxoid.
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Grades 3
- Grade 3 chondrosarcoma is increasingly faster-growing cancer, with more varied and abnormal-looking cells.
- Characterized by myxoid stroma, nuclear pleomorphism and mitoses.
- Absent chondroid matrix.
- These are much more likely to infiltrate surrounding tissues, lymph nodes, and organs.
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Grade 4
- Some, but not all, authorities and medical facilities assign a "Grade 4" to the most anaplastic, undifferentiated cartilage-derived tumors.