Chondrosarcoma classification: Difference between revisions

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*Clear cell chondrosarcoma
*Clear cell chondrosarcoma
*Dedifferentiated chondrosarcoma
*Dedifferentiated chondrosarcoma
==Grading==
Physicians grade chondrosarcoma using several criteria, but particularly on how abnormal the cancerous cells appear under the microscope and the growth rate of the tumors themselves, both of which are directly linked to the propensity of the cancer to invade locally, and to spread widely to distant organs and sites in the body (called [[metastasis]]).
====Grade 1====
*Chondrosarcoma grows relatively slowly, has cells whose [[histological]] appearance is quite similar to cells of normal cartilage.
*Mostly chondroid matrix, little if any myxoid.
*Mild-to-moderate increase of cellularity +/- binucleated cells.
*Have much less aggressive invasive and metastatic properties.
{| align
|-valign="top"
| [[Image:800px-Bone Chondrosarcoma Grade1 HP2 PA.JPG|thumb|350px|Grade 1 - Somewhat cellular cartilage with binucleation]]
|}
====Grade 2====
*Intermediate grade chondrosarcoma.
*Little chondroid matrix, Necrosis and more common prominent myxoid.
{| align
|-valign="top"
| [[Image:800px-Bone Chondrosarcoma Grade2 HP PA.jpg|thumb|350px|Grade 2 - Very cellular cartilage with obvious hyperchromasia and nuclear atypia]]
|}
====Grades 3====
*Grade 3 chondrosarcoma is increasingly faster-growing cancer, with more varied and abnormal-looking cells.
*Characterized by myxoid stroma, nuclear [[pleomorphism]] and [[mitoses]].
*Absent chondroid matrix.
*These are much more likely to infiltrate surrounding tissues, [[lymph nodes]], and organs.
{| align
|-valign="top"
| [[Image:800px-Bone Chondrosarcoma Grade3 HP PA.JPG|thumb|350px|Grade 3 - Even more cellular neoplastic cartilage with high grade nuclear atypia]]
|}
====Grade 4====
*Some, but not all, authorities and medical facilities assign a "Grade 4" to the most [[anaplastic]], undifferentiated cartilage-derived tumors.


==References==
==References==

Revision as of 15:03, 31 August 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chondrosarcoma may be classified into six subtypes based on topographical location of tumor, histological characteristics, makeup of surrounding matrix material.

Classification

Chondrosarcoma is classified into six "subtypes" based on: (a) The topographical location of the tumor. (b) The histological characteristics of the cancerous cartilage cells. (c) The makeup of the surrounding matrix material associated with the tumor.

  • Chondrosarcoma NOS ("Not Otherwise Specified")
  • Juxtacortical chondrosarcoma
  • Myxoid chondrosarcoma
  • Mesenchymal chondrosarcoma
  • Clear cell chondrosarcoma
  • Dedifferentiated chondrosarcoma

References


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