Chondrosarcoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Complications that can develop as a result of chondrosarcoma are metastasis and recurrence. The prognosis of chondrosarcoma is good with treatment. Chondrosarcoma is associated with a 5 year survival rate of 75%. The presence of grade 3 lesions are associated with a particularly poor prognosis.

Complications

• Chondrosarcoma may cause metastasis to other organs.
• Lung is the most common location for metastatic disease.
• Chondrosarcoma may recur and may need treatment with surgery, chemotherapy or radiation. Unlike other cancers, chondrosarcoma can return many years later. Follow up scans are extremely important for chondrosarcoma to make sure there has been no recurrence or metastasis.

Prognosis

• Generally, chondrosarcoma carries a good prognosis.
• Chondrosarcoma is associated with a 5 year survival rate of 75%.
• Depending upon the subtype, prognosis vary substantially:
  • Chondrosarcoma NOS: 70% 5 year survival.
  • Myxoid chondrosarcoma: 70% 5 year survival.
  • Mesenchymal chondrosarcoma: 50% 5 year survival.
  • Dedifferentiated chondrosarcoma: 10% 5 year survival.
• Prognosis varies with grade:
  • Grade 1: 90% 5 year survival.
  • Grade 3: 29% 5 year survival.
• Prognosis varies with location:
  • Long bones have a better prognosis than axial skeleton.

References

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