Peutz-Jeghers syndrome screening: Difference between revisions

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{{Peutz-Jeghers syndrome}}
{{Peutz-Jeghers syndrome}}


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{{CMG}} {{AE}} {{MJK}}


==Overview==
==Overview==
Screening for cancerous lesions by small intestine radiography, esophagogastroduodenoscopy, colonoscopy, pancreatic ultrasound, pelvic ultrasound, [[mammography]], and Papanicolaou (Pap) test is recommended among patients with Peutz-Jeghers syndrome.  
Screening for cancerous lesions by small intestine radiography, [[esophagogastroduodenoscopy]] (EGD), colonoscopy, pancreatic ultrasound, pelvic ultrasound, [[mammography]], and Papanicolaou (Pap) test are recommended among patients with Peutz-Jeghers syndrome.  
==Screening==
==Screening==
Screening includes [[Esophagogastroduodenoscopy|upper GI endoscopy]], [[enteroclysis]], and [[colonoscopy]] to check for the locations of the [[hamartomas]]. To check for cancerous lesions, [[endoscopic ultrasound]], testicular ultrasound and imaging studies of the liver and the pancreas are indicated because of the risk of pancreatic cancer as well as gallbladder polyps and cancer. These imaging studies may include [[ultrasonography]] as well as CT with pancreatic details or [[magnetic resonance cholangiopancreatography]] (MRCP).
Patients who are at risk of developing Peutz-Jeghers syndrome are  screened for the locations of the [[hamartomas]] by:
*[[Esophagogastroduodenoscopy|upper GI endoscopy]]
*[[Enteroclysis]]
*[[Colonoscopy]]


In addition, an annual physical examination that includes evaluation of the breasts, abdomen, pelvis, and testes should be done by a physician. An annual complete blood count to check for anemia should be done. If bleeding is found, removal of hemorrhagic or large polyps (>5 mm) by endoscopic polypectomy should be performed.
Screening for cancerous lesions include the following:
*Small intestine radiography (every 2 years)
*[[Esophagogastroduodenoscopy]] (every 2 years)
*[[Colonoscopy]] every 2 years
*Pancreatic ultrasound (annually)
*[[Endoscopic ultrasound]]
*[[Magnetic resonance cholangiopancreatography]] (MRCP)
*Abdominal CT
*Pelvic ultrasound (annually)
*Testicular ultrasound (annually)
*[[Mammography]] at ages 25, 30, 35, and 38 years, then every 2 years until age 50 years, then annually
*Cervical Papanicolaou (Pap) test (annually).
*Annual physical examination that includes evaluation of the breasts, abdomen, pelvis, and testes should be done by a physician
*Annual complete blood count to check for anemia should be done


Some suggestions for surveillance for cancer include the following:
Small intestine with small bowel radiography every 2 years,
Esophagogastroduodenoscopy and colonoscopy every 2 years,
Ultrasound of the pancreas yearly,
Ultrasound of the pelvis (women) and testes (men) yearly,
Mammography (women) at ages 25, 30, 35, and 38 years, then every 2 years until age 50 years, then annually, and
Papanicolaou (Pap) test every year.
 
Follow-up care should be supervised by a gastroenterologist familiar with Peutz-Jeghers syndrome. Genetic consultation and counseling as well as urological and gynecological consultations are required in the management of these patients.


== References ==
== References ==
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[[Category:Genetic disorders]]
[[Category:Genetic disorders]]
[[Category:Syndromes]]
[[Category:Syndromes]]
 
[[de:Peutz-Jeghers-Syndrom]]
[[fr:Syndrome de Peutz-Jeghers]]
[[it:Sindrome di Peutz-Jeghers]]
[[nl:Syndroom van Peutz-Jeghers]]
[[pl:Zespół Peutza-Jeghersa]]
[[tr:Peutz-Jeghers sendromu]]


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Revision as of 18:51, 9 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Screening for cancerous lesions by small intestine radiography, esophagogastroduodenoscopy (EGD), colonoscopy, pancreatic ultrasound, pelvic ultrasound, mammography, and Papanicolaou (Pap) test are recommended among patients with Peutz-Jeghers syndrome.

Screening

Patients who are at risk of developing Peutz-Jeghers syndrome are screened for the locations of the hamartomas by:


Screening for cancerous lesions include the following:

  • Small intestine radiography (every 2 years)
  • Esophagogastroduodenoscopy (every 2 years)
  • Colonoscopy every 2 years
  • Pancreatic ultrasound (annually)
  • Endoscopic ultrasound
  • Magnetic resonance cholangiopancreatography (MRCP)
  • Abdominal CT
  • Pelvic ultrasound (annually)
  • Testicular ultrasound (annually)
  • Mammography at ages 25, 30, 35, and 38 years, then every 2 years until age 50 years, then annually
  • Cervical Papanicolaou (Pap) test (annually).
  • Annual physical examination that includes evaluation of the breasts, abdomen, pelvis, and testes should be done by a physician
  • Annual complete blood count to check for anemia should be done


References

Template:Digestive system neoplasia


Template:WH Template:WS