Transitional cell carcinoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Gross Pathology=== | |||
===Microscopic Pathology=== | |||
* Non-invasive urothelial carcinoma<ref name="pmid10649257">{{cite journal| author=Cheng L, Cheville JC, Neumann RM, Bostwick DG| title=Flat intraepithelial lesions of the urinary bladder. | journal=Cancer | year= 2000 | volume= 88 | issue= 3 | pages= 625-31 | pmid=10649257 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10649257 }} </ref><ref name="pmid12861056">{{cite journal| author=McKenney JK, Amin MB, Young RH| title=Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases. | journal=Mod Pathol | year= 2003 | volume= 16 | issue= 7 | pages= 623-9 | pmid=12861056 | doi=10.1097/01.MP.0000073973.74228.1E | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12861056 }} </ref><ref name="pmid22520573">{{cite journal| author=Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B et al.| title=Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients. | journal=Urol Oncol | year= 2013 | volume= 31 | issue= 8 | pages= 1584-90 | pmid=22520573 | doi=10.1016/j.urolonc.2012.03.009 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22520573 }} </ref> | |||
:* Flat lesions | |||
::* On microscopic histopathological analysis, loss of [[cell]] polarity, [[nuclear]] crowding, and cytologic [[atypia]] are characteristic findings. | |||
:* [[Papillary]] lesions | |||
::* On microscopic histopathological analysis, fibrovascular stalks, umbrella cells, and [[eosinophilic]] cytoplasm are characteristic findings. | |||
* Invasive urothelial carcinoma | |||
:* On microscopic histopathological analysis, invasion beyond the [[basement membrane]] is the characteristic finding.<ref name="pmid21360040">{{cite journal| author=Pons F, Orsola A, Morote J, Bellmunt J| title=Variant forms of bladder cancer: basic considerations on treatment approaches. | journal=Curr Oncol Rep | year= 2011 | volume= 13 | issue= 3 | pages= 216-21 | pmid=21360040 | doi=10.1007/s11912-011-0161-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21360040 }} </ref> | |||
=== | |||
==References== | ==References== | ||
Revision as of 15:07, 11 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Gross Pathology
Microscopic Pathology
- Flat lesions
- Papillary lesions
- On microscopic histopathological analysis, fibrovascular stalks, umbrella cells, and eosinophilic cytoplasm are characteristic findings.
- Invasive urothelial carcinoma
- On microscopic histopathological analysis, invasion beyond the basement membrane is the characteristic finding.[4]
=
References
- ↑ Cheng L, Cheville JC, Neumann RM, Bostwick DG (2000). "Flat intraepithelial lesions of the urinary bladder". Cancer. 88 (3): 625–31. PMID 10649257.
- ↑ McKenney JK, Amin MB, Young RH (2003). "Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases". Mod Pathol. 16 (7): 623–9. doi:10.1097/01.MP.0000073973.74228.1E. PMID 12861056.
- ↑ Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B; et al. (2013). "Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients". Urol Oncol. 31 (8): 1584–90. doi:10.1016/j.urolonc.2012.03.009. PMID 22520573.
- ↑ Pons F, Orsola A, Morote J, Bellmunt J (2011). "Variant forms of bladder cancer: basic considerations on treatment approaches". Curr Oncol Rep. 13 (3): 216–21. doi:10.1007/s11912-011-0161-4. PMID 21360040.