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| ===Gross Pathology=== | | ===Gross Pathology=== |
| ===Microscopic Pathology=== | | ===Microscopic Pathology=== |
| * Non-invasive urothelial carcinoma<ref name="pmid10649257">{{cite journal| author=Cheng L, Cheville JC, Neumann RM, Bostwick DG| title=Flat intraepithelial lesions of the urinary bladder. | journal=Cancer | year= 2000 | volume= 88 | issue= 3 | pages= 625-31 | pmid=10649257 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10649257 }} </ref><ref name="pmid12861056">{{cite journal| author=McKenney JK, Amin MB, Young RH| title=Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases. | journal=Mod Pathol | year= 2003 | volume= 16 | issue= 7 | pages= 623-9 | pmid=12861056 | doi=10.1097/01.MP.0000073973.74228.1E | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12861056 }} </ref><ref name="pmid22520573">{{cite journal| author=Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B et al.| title=Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients. | journal=Urol Oncol | year= 2013 | volume= 31 | issue= 8 | pages= 1584-90 | pmid=22520573 | doi=10.1016/j.urolonc.2012.03.009 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22520573 }} </ref> | | Urothelial carcinomas have 2 main growth patterns: |
| :* Flat lesions
| | * Papillary urothelial carcinomas: Have slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity. |
| ::* On microscopic histopathological analysis, loss of [[cell]] polarity, [[nuclear]] crowding, and cytologic [[atypia]] are characteristic findings. | | * Flat urothelial carcinomas: Lay flat in the lining of the renal pelvis and ureter. They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity |
| :* [[Papillary]] lesions
| |
| ::* On microscopic histopathological analysis, fibrovascular stalks, umbrella cells, and [[eosinophilic]] cytoplasm are characteristic findings.
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| * Invasive urothelial carcinoma
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| :* On microscopic histopathological analysis, invasion beyond the [[basement membrane]] is the characteristic finding.<ref name="pmid21360040">{{cite journal| author=Pons F, Orsola A, Morote J, Bellmunt J| title=Variant forms of bladder cancer: basic considerations on treatment approaches. | journal=Curr Oncol Rep | year= 2011 | volume= 13 | issue= 3 | pages= 216-21 | pmid=21360040 | doi=10.1007/s11912-011-0161-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21360040 }} </ref>
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| ==References== | | ==References== |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Gross Pathology
Microscopic Pathology
Urothelial carcinomas have 2 main growth patterns:
- Papillary urothelial carcinomas: Have slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity.
- Flat urothelial carcinomas: Lay flat in the lining of the renal pelvis and ureter. They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity
References
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