Transitional cell carcinoma classification

Transitional cell carcinoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Transitional cell carcinoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Cystoscopy and Bladder Biopsy
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Transitional cell carcinoma classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Transitional cell carcinoma classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Transitional cell carcinoma classification
CDC on Transitional cell carcinoma classification
Transitional cell carcinoma classification in the news
Blogs on Transitional cell carcinoma classification
Directions to Hospitals Treating Transitional cell carcinoma
Risk calculators and risk factors for Transitional cell carcinoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

Based on the growth pattern, transitional cell tumors may be classified into two subtypes:

Type	Description
Papillary urothelial carcinoma	Have slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity
Non-papillary urothelial carcinomas	Sessile or nodular tumors They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity

WHO Classification

The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumors:

Transitional cell tumors

Infiltrating urothelial carcinoma with squamous differentiation with glandular differentiation with trophoblastic differentiation Nested Microcystic Micropapillary Lymphoepithelioma-like Lymphoma-like Plasmacytoid Sarcomatoid Giant cell Undifferentiated

Non-invasive urothelial carcinoma Urothelial carcinoma in situ High grade papillary urothelial carcinoma Low grade papillary urothelial carcinoma Non-invasive papillary urothelial neoplasm of low malignant potential Urothelial papilloma Inverted urothelial papilloma

Grading

According to the WHO grading criteria, there are two grades of transitional cell carcinoma based on the degree of cellular differentiation:

Grade	Description
Low grade	Tumors with the least degree of cellular anaplasia Rarely invades the muscular wall of the bladder or spreads to other parts of the body Often recurs in the after treatment
High grade	Tumors with the most severe degrees of cellular anaplasia Commonly recurs and also has a strong tendency to invade the muscular wall of the bladder and spread to other parts of the body. High grade transitional cell carcinoma is much more likely to result in death