Alzheimer's disease other diagnostic studies: Difference between revisions
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* Genotyping for Apolipoprotein E (APOE)† may be helpful in the diagnosis of Alzheimer's disease (AD), although it is not routinely recommended.<ref name="pmid7646655">{{cite journal| author=Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN et al.| title=Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. | journal=JAMA | year= 1995 | volume= 273 | issue= 16 | pages= 1274-8 | pmid=7646655 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7646655 }} </ref><ref name="pmid9468467">{{cite journal| author=Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD et al.| title=Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. | journal=N Engl J Med | year= 1998 | volume= 338 | issue= 8 | pages= 506-11 | pmid=9468467 | doi=10.1056/NEJM199802193380804 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9468467 }} </ref> Findings suggestive of Alzheimer's disease include: | * Genotyping for Apolipoprotein E (APOE)† may be helpful in the diagnosis of Alzheimer's disease (AD), although it is not routinely recommended.<ref name="pmid7646655">{{cite journal| author=Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN et al.| title=Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. | journal=JAMA | year= 1995 | volume= 273 | issue= 16 | pages= 1274-8 | pmid=7646655 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7646655 }} </ref><ref name="pmid9468467">{{cite journal| author=Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD et al.| title=Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. | journal=N Engl J Med | year= 1998 | volume= 338 | issue= 8 | pages= 506-11 | pmid=9468467 | doi=10.1056/NEJM199802193380804 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9468467 }} </ref> Findings suggestive of Alzheimer's disease include: | ||
** APOE ε-4 allele of APOE gene is positive | ** APOE ε-4 allele of APOE gene is positive | ||
** APOE ε-3 and APOE ε-2 | ** APOE ε-3 and APOE ε-2‡ are positive | ||
‡ although certain studies have shown the protective effect of APOE ε-2 on AD | |||
* Genotyping for the following may be helpful in the diagnosis of AD: | * Genotyping for the following may be helpful in the diagnosis of AD: | ||
Revision as of 13:27, 21 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There are no other diagnostic studies associated with [disease name].
OR
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].
Other Diagnostic Studies
Genetic testing
- Genotyping for Apolipoprotein E (APOE)† may be helpful in the diagnosis of Alzheimer's disease (AD), although it is not routinely recommended.[1][2] Findings suggestive of Alzheimer's disease include:
- APOE ε-4 allele of APOE gene is positive
- APOE ε-3 and APOE ε-2‡ are positive
‡ although certain studies have shown the protective effect of APOE ε-2 on AD
- Genotyping for the following may be helpful in the diagnosis of AD:
- Amyloid Precursor Protein (APP)†
- Presenilin (PSEN) 1 and 2 gene
† APP is also activated by APOE[3]
References
- ↑ Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN; et al. (1995). "Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals". JAMA. 273 (16): 1274–8. PMID 7646655.
- ↑ Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD; et al. (1998). "Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease". N Engl J Med. 338 (8): 506–11. doi:10.1056/NEJM199802193380804. PMID 9468467.
- ↑ Huang YA, Zhou B, Wernig M, Südhof TC (2017). "ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion". Cell. 168 (3): 427–441.e21. doi:10.1016/j.cell.2016.12.044. PMC 5310835. PMID 28111074.