Syndrome of inappropriate antidiuretic hormone differential diagnosis: Difference between revisions

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__NOTOC__
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{{Syndrome of inappropriate antidiuretic hormone}}
{{Syndrome of inappropriate antidiuretic hormone}}
{{CMG}}; {{AE}} {{Vbe}}
{{CMG}}; {{AE}}{{EG}}


==Overview==  
==Overview==  
[[SIADH| Syndrome of inappropriate antidiuretic hormone]] consists of [[hyponatremia]], inappropriately elevated urine [[osmolality]], excessive urine [[sodium]], and decreased serum [[osmolality]] in a [[euvolemic]] patient without [[edema]]. These findings should occur in the absence of [[diuretic]] treatment with normal [[cardiac]], [[renal]], [[adrenal]], [[hepatic]], and [[Thyroid|thyroid function]]. [[Hyponatremia]] occurs in about 30% of hospitalized patients and [[SIADH]] is the most frequent cause of [[hyponatremia]]. Differentiating SIADH from other causes of [[hyponatremia]] becomes essential to evaluate the treatment plan.
Syndrome of inappropriate antidiuretic hormone (SIADH) must be differentiated from other causes of [[hyponatremia]], such as [[cerebral salt wasting syndrome]], [[adrenal insufficiency]], [[hypopituitarism]], and [[psychogenic polydipsia]].
 
==Differentiating Syndrome of Inappropriate Antidiuretic Hormone from other Diseases==
==Differentiating Syndrome of inappropriate antidiuretic hormone from other Diseases==
[[SIADH]] must be differentiated from cerebral salt wasting, [[ adrenal insufficiency]], [[hypopituitarism]], [[hypothyroidism]], and [[psychogenic polydipsia]]<ref name="pmid27936532">{{cite journal |vauthors=Heidelbaugh JJ |title=Endocrinology Update: Hypopituitarism |journal=FP Essent |volume=451 |issue= |pages=25–30 |year=2016 |pmid=27936532 |doi= |url=}}</ref><ref name="pmid15241506">{{cite journal |vauthors=Hammer F, Arlt W |title=[Hypopituitarism] |language=German |journal=Internist (Berl) |volume=45 |issue=7 |pages=795–811; quiz 812–3 |year=2004 |pmid=15241506 |doi=10.1007/s00108-004-1216-5 |url=}}</ref><ref name="pmid25712898">{{cite journal |vauthors=de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E |title=The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia |journal=Endocr Connect |volume=4 |issue=2 |pages=86–91 |year=2015 |pmid=25712898 |pmc=4401105 |doi=10.1530/EC-14-0113 |url=}}</ref>
[[SIADH]] must be differentiated from cerebral salt wasting, [[ adrenal insufficiency]], [[hypopituitarism]], [[hypothyroidism]], and [[psychogenic polydipsia]]<ref name="pmid27936532">{{cite journal |vauthors=Heidelbaugh JJ |title=Endocrinology Update: Hypopituitarism |journal=FP Essent |volume=451 |issue= |pages=25–30 |year=2016 |pmid=27936532 |doi= |url=}}</ref><ref name="pmid15241506">{{cite journal |vauthors=Hammer F, Arlt W |title=[Hypopituitarism] |language=German |journal=Internist (Berl) |volume=45 |issue=7 |pages=795–811; quiz 812–3 |year=2004 |pmid=15241506 |doi=10.1007/s00108-004-1216-5 |url=}}</ref><ref name="pmid25712898">{{cite journal |vauthors=de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E |title=The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia |journal=Endocr Connect |volume=4 |issue=2 |pages=86–91 |year=2015 |pmid=25712898 |pmc=4401105 |doi=10.1530/EC-14-0113 |url=}}</ref>


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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Cerebral salt wasting syndrome]]
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Cerebral salt wasting syndrome]]
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
*[[Hypovolemia]]
*[[Hyponatremia]]
*[[Hyponatremia]]
*Urine [[sodium]] concentration > 40 mMol/l
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
*[[Hypovolemia]]
*Intracranial [[diseases]], such as:
*Intracranial [[diseases]], such as:
**[[Tumor]]
**[[Tumor]]
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Adrenal insufficiency]]
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Adrenal insufficiency]]
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
*[[Hypovolemia]]
*[[Hyponatremia]]
*[[Hyponatremia]]
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
*[[Weight loss]]
*[[Weight loss]]
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Hypopituitarism]]
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Hypopituitarism]]
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
*[[Hypovolemia]]
*[[Hyponatremia]]
*[[Hyponatremia]]
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Psychogenic polydipsia]]  
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Psychogenic polydipsia]]  
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
*[[Hypovolemia]]  
*[[Fluid]] overload
*[[Hyponatremia]]
*[[Hyponatremia]]
| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;"|
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{{Reflist|2}}
{{Reflist|2}}


[[Category:Needs content]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Neurology]]
[[Category:Neurology]]

Revision as of 19:50, 11 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Overview

Syndrome of inappropriate antidiuretic hormone (SIADH) must be differentiated from other causes of hyponatremia, such as cerebral salt wasting syndrome, adrenal insufficiency, hypopituitarism, and psychogenic polydipsia.

Differentiating Syndrome of Inappropriate Antidiuretic Hormone from other Diseases

SIADH must be differentiated from cerebral salt wasting, adrenal insufficiency, hypopituitarism, hypothyroidism, and psychogenic polydipsia[1][2][3]

Differential Diagnosis Similar Features Differentiating Features
SIADH

-

Cerebral salt wasting syndrome
Adrenal insufficiency
Hypopituitarism
Psychogenic polydipsia

References

  1. Heidelbaugh JJ (2016). "Endocrinology Update: Hypopituitarism". FP Essent. 451: 25–30. PMID 27936532.
  2. Hammer F, Arlt W (2004). "[Hypopituitarism]". Internist (Berl) (in German). 45 (7): 795–811, quiz 812–3. doi:10.1007/s00108-004-1216-5. PMID 15241506.
  3. de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E (2015). "The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia". Endocr Connect. 4 (2): 86–91. doi:10.1530/EC-14-0113. PMC 4401105. PMID 25712898.


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