Syndrome of inappropriate antidiuretic hormone laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
[[Laboratory]] findings which are helpful in diagnosing [[SIADH]] include | [[Laboratory]] findings which are helpful in diagnosing [[Syndrome of inappropriate antidiuretic hormone|Syndrome of inappropriate antidiuretic hormone (SIADH)]] include serum [[electrolytes]] (especially [[sodium]]), [[BUN|blood urea nitrogen (BUN)]], [[creatinine]], [[glucose]] levels, and [[osmolality]]. Laboratory findings in patients with [[SIADH]] may show [[hyponatremia]] ([[sodium]] <135 mEq/L) and low serum [[osmolality]] (< 280 mOsm/kg). Patients with [[SIADH]] have elevated urinary [[sodium]] level (> 20 mMol/L) and urine [[osmolality]] (generally > 100 mOsm/L). Patients with [[SIADH]] also have low [[BUN]], normal [[creatinine]], [[hypouricemia]], and [[hypoalbuminemia]]. | ||
[[BUN]], normal [[creatinine]], [[hypouricemia]] and [[hypoalbuminemia]] | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
[[Laboratory]] findings consistent with the [[diagnosis]] of [[SIADH]] are | [[Laboratory]] findings consistent with the [[diagnosis]] of [[SIADH]] are include:<ref name="pmid1245796">{{cite journal |vauthors=Shimamoto K, Murase T, Yamaji T |title=A heterologous radioimmunoassay for arginine vasopressin |journal=J. Lab. Clin. Med. |volume=87 |issue=2 |pages=338–44 |year=1976 |pmid=1245796 |doi= |url=}}</ref> | ||
*[[Hyponatremia]] (< 135 mEq/l) | |||
*[[Hyponatremia]](<135 | *[[Hypoosmolality]] (< 280 mOsm/kg) | ||
*[[Hypoosmolality]](< | |||
*Low [[BUN]] levels | *Low [[BUN]] levels | ||
*[[Hypoalbuminemia]] | *[[Hypoalbuminemia]] | ||
*[[Hypouricemia ]] | *[[Hypouricemia]] | ||
*Normal[[ | *Normal [[creatinine]] | ||
*Normal [[thyroid hormones]] | *Normal [[thyroid hormones]] | ||
*Normal[[ cortisol]] | *Normal [[cortisol]] | ||
*Increased [[GFR]] | *Increased [[GFR]] | ||
*Increased plasma [[ADH]] levels | *Increased plasma [[ADH]] levels | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:56, 11 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
Laboratory findings which are helpful in diagnosing Syndrome of inappropriate antidiuretic hormone (SIADH) include serum electrolytes (especially sodium), blood urea nitrogen (BUN), creatinine, glucose levels, and osmolality. Laboratory findings in patients with SIADH may show hyponatremia (sodium <135 mEq/L) and low serum osmolality (< 280 mOsm/kg). Patients with SIADH have elevated urinary sodium level (> 20 mMol/L) and urine osmolality (generally > 100 mOsm/L). Patients with SIADH also have low BUN, normal creatinine, hypouricemia, and hypoalbuminemia.
Laboratory Findings
Laboratory findings consistent with the diagnosis of SIADH are include:[1]
- Hyponatremia (< 135 mEq/l)
- Hypoosmolality (< 280 mOsm/kg)
- Low BUN levels
- Hypoalbuminemia
- Hypouricemia
- Normal creatinine
- Normal thyroid hormones
- Normal cortisol
- Increased GFR
- Increased plasma ADH levels