Syndrome of inappropriate antidiuretic hormone laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
[[Laboratory]] findings consistent with the [[diagnosis]] of [[SIADH]] include:<ref name="pmid1245796">{{cite journal |vauthors=Shimamoto K, Murase T, Yamaji T |title=A heterologous radioimmunoassay for arginine vasopressin |journal=J. Lab. Clin. Med. |volume=87 |issue=2 |pages=338–44 |year=1976 |pmid=1245796 |doi= |url=}}</ref><ref name="pmid26069838">{{cite journal |vauthors=Laville M, Burst V, Peri A, Verbalis JG |title=Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases |journal=Clin Kidney J |volume=6 |issue=Suppl 1 |pages=i1–i20 |year=2013 |pmid=26069838 |pmc=4438352 |doi=10.1093/ckj/sft113 |url=}}</ref><ref name="pmid20935451">{{cite journal |vauthors=Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P |title=Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |journal=J. Endocrinol. Invest. |volume=33 |issue=9 |pages=671–82 |year=2010 |pmid=20935451 |doi=10.1007/BF03346668 |url=}}</ref><ref name="pmid20935451">{{cite journal |vauthors=Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P |title=Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |journal=J. Endocrinol. Invest. |volume=33 |issue=9 |pages=671–82 |year=2010 |pmid=20935451 |doi=10.1007/BF03346668 |url=}}</ref><ref name="pmid25657991">{{cite journal |vauthors=Oh JY, Shin JI |title=Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences |journal=Front Pediatr |volume=2 |issue= |pages=146 |year=2014 |pmid=25657991 |pmc=4302789 |doi=10.3389/fped.2014.00146 |url=}}</ref> | [[Laboratory]] findings consistent with the [[diagnosis]] of [[SIADH]] include:<ref name="pmid1245796">{{cite journal |vauthors=Shimamoto K, Murase T, Yamaji T |title=A heterologous radioimmunoassay for arginine vasopressin |journal=J. Lab. Clin. Med. |volume=87 |issue=2 |pages=338–44 |year=1976 |pmid=1245796 |doi= |url=}}</ref><ref name="pmid26069838">{{cite journal |vauthors=Laville M, Burst V, Peri A, Verbalis JG |title=Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases |journal=Clin Kidney J |volume=6 |issue=Suppl 1 |pages=i1–i20 |year=2013 |pmid=26069838 |pmc=4438352 |doi=10.1093/ckj/sft113 |url=}}</ref><ref name="pmid20935451">{{cite journal |vauthors=Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P |title=Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |journal=J. Endocrinol. Invest. |volume=33 |issue=9 |pages=671–82 |year=2010 |pmid=20935451 |doi=10.1007/BF03346668 |url=}}</ref><ref name="pmid20935451">{{cite journal |vauthors=Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P |title=Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |journal=J. Endocrinol. Invest. |volume=33 |issue=9 |pages=671–82 |year=2010 |pmid=20935451 |doi=10.1007/BF03346668 |url=}}</ref><ref name="pmid25657991">{{cite journal |vauthors=Oh JY, Shin JI |title=Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences |journal=Front Pediatr |volume=2 |issue= |pages=146 |year=2014 |pmid=25657991 |pmc=4302789 |doi=10.3389/fped.2014.00146 |url=}}</ref><ref name="pmid2350904">{{cite journal |vauthors=Maesaka JK, Batuman V, Yudd M, Salem M, Sved AF, Venkatesan J |title=Hyponatremia and hypouricemia: differentiation from SIADH |journal=Clin. Nephrol. |volume=33 |issue=4 |pages=174–8 |year=1990 |pmid=2350904 |doi= |url=}}</ref> | ||
*[[Hyponatremia]] (< 135 mEq/l) | *[[Hyponatremia]] (< 135 mEq/l) | ||
*[[Hypoosmolality]] (< 280 mOsm/kg) | *[[Hypoosmolality]] (< 280 mOsm/kg) | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
Laboratory findings which are helpful in diagnosing syndrome of inappropriate antidiuretic hormone (SIADH) include serum electrolytes (especially sodium), blood urea nitrogen (BUN), creatinine, glucose levels, and osmolality. Laboratory findings in patients with SIADH may show hyponatremia (sodium <135 mEq/L) and low serum osmolality (< 280 mOsm/kg). Patients with SIADH have elevated urinary sodium level (> 20 mMol/L) and urine osmolality (generally > 100 mOsm/L). Patients with SIADH also have low BUN, normal creatinine, hypouricemia, and hypoalbuminemia.
Laboratory Findings
Laboratory findings consistent with the diagnosis of SIADH include:[1][2][3][3][4][5]
- Hyponatremia (< 135 mEq/l)
- Hypoosmolality (< 280 mOsm/kg)
- Low BUN levels
- Hypoalbuminemia
- Hypouricemia
- Normal creatinine
- Normal thyroid hormones
- Normal cortisol
- Increased GFR
- Increased plasma ADH levels
References
- ↑ Shimamoto K, Murase T, Yamaji T (1976). "A heterologous radioimmunoassay for arginine vasopressin". J. Lab. Clin. Med. 87 (2): 338–44. PMID 1245796.
- ↑ Laville M, Burst V, Peri A, Verbalis JG (2013). "Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases". Clin Kidney J. 6 (Suppl 1): i1–i20. doi:10.1093/ckj/sft113. PMC 4438352. PMID 26069838.
- ↑ 3.0 3.1 Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P (2010). "Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)". J. Endocrinol. Invest. 33 (9): 671–82. doi:10.1007/BF03346668. PMID 20935451.
- ↑ Oh JY, Shin JI (2014). "Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences". Front Pediatr. 2: 146. doi:10.3389/fped.2014.00146. PMC 4302789. PMID 25657991.
- ↑ Maesaka JK, Batuman V, Yudd M, Salem M, Sved AF, Venkatesan J (1990). "Hyponatremia and hypouricemia: differentiation from SIADH". Clin. Nephrol. 33 (4): 174–8. PMID 2350904.