PLK3: Difference between revisions

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Orthologs
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Latest revision as of 18:18, 7 September 2017

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.^[1]^[2]

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.^[1]

Interactions

PLK3 has been shown to interact with:

References

↑ ^1.0 ^1.1 "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)".
↑ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
↑ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
↑ ^4.0 ^4.1 Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661.
↑ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.

Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science. 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID 9278512.
Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997). "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions". J. Biol. Chem. 272 (45): 28646–51. doi:10.1074/jbc.272.45.28646. PMID 9353331.
Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297.
Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites". Genes Dev. 14 (3): 289–300. PMC 316358. PMID 10673501.
Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer. 27 (3): 332–6. doi:10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K. PMID 10679924.
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389–94. doi:10.1073/pnas.190030497. PMC 27034. PMID 10973490.
Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900.
Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833): 102–7. doi:10.1038/35075107. PMID 11333986.
Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.
Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene. 20 (46): 6784–93. doi:10.1038/sj.onc.1204883. PMID 11709713.
Ahn JY, Li X, Davis HL, Canman CE (2002). "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain". J. Biol. Chem. 277 (22): 19389–95. doi:10.1074/jbc.M200822200. PMID 11901158.
Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002). "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase". Mol. Cell. 9 (3): 515–25. doi:10.1016/S1097-2765(02)00473-2. PMID 11931760.
Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002). "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity". Mol. Cell. Biol. 22 (10): 3450–9. doi:10.1128/MCB.22.10.3450-3459.2002. PMC 133784. PMID 11971976.
Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661.
Tsvetkov L, Xu X, Li J, Stern DF (2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody". J. Biol. Chem. 278 (10): 8468–75. doi:10.1074/jbc.M211202200. PMID 12493754.
Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W (2003). "Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2". Cell Cycle. 1 (6): 424–9. doi:10.4161/cc.1.6.271. PMID 12548019.
Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation". Oncogene. 23 (15): 2658–63. doi:10.1038/sj.onc.1207425. PMID 14968113.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)".

[pmid8702627-2] Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.

[pmid10557092-3] Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.

[pmid12242661-4] 4.0 ^4.1 Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661.

[pmid11551930-5] Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Polo-like kinase 3 (Drosophila)''', also known as '''PLK3''', is an [[enzyme]] which in humans is encoded by the ''PLK3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1263| accessdate = }}</ref><ref name="pmid8702627">{{cite journal | vauthors = Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W | title = Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas | journal = J. Biol. Chem. | volume = 271 | issue = 32 | pages = 19402–8 | date = August 1996 | pmid = 8702627 | doi = 10.1074/jbc.271.32.19402 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8702627 }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Polo-like kinase 3 (Drosophila)
- | HGNCid = 2154
- | Symbol = PLK3
- | AltSymbols =; CNK; FNK; PRK
- | OMIM = 602913
- | ECnumber =
- | Homologene = 20865
- | MGIid = 109604
- | GeneAtlas_image1 = PBB_GE_PLK3_204958_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PLK3_215462_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component =
- | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1263
-    | Hs_Ensembl = ENSG00000173846
-    | Hs_RefseqProtein = NP_004064
-    | Hs_RefseqmRNA = NM_004073
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 45038723
-    | Hs_GenLoc_end = 45049479
-    | Hs_Uniprot = Q9H4B4
-    | Mm_EntrezGene = 12795
-    | Mm_Ensembl = ENSMUSG00000028680
-    | Mm_RefseqmRNA = NM_013807
-    | Mm_RefseqProtein = NP_038835
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 4
-    | Mm_GenLoc_start = 116626587
-    | Mm_GenLoc_end = 116631884
-    | Mm_Uniprot = Q3U0L5
-  }}
-}}
-'''Polo-like kinase 3 (Drosophila)''', also known as '''PLK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1263| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+Cytokine-inducible kinase is a putative serine/threonine kinase.  CNK contains both a catalytic domain and a putative regulatory domain.  It may play a role in regulation of [[cell cycle]] progression and [[tumorigenesis]].<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = Cytokine-inducible kinase is a putative serine/threonine kinase.  CNK contains both a catalytic domain and a putative regulatory domain.  It may play a role in regulation of cell cycle progression and tumorigenesis.<ref name="entrez">{{cite web | title = Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1263| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+PLK3 has been shown to [[Protein-protein interaction|interact]] with:
+* [[CDC25C]],<ref name = pmid10557092>{{cite journal | vauthors = Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W | title = The physical association and phosphorylation of Cdc25C protein phosphatase by Prk | journal = Oncogene | volume = 18 | issue = 44 | pages = 6029–36 | date = Oct 1999 | pmid = 10557092 | doi = 10.1038/sj.onc.1202983 }}</ref>
+* [[CHEK2]],<ref name = pmid12242661>{{cite journal | vauthors = Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ | title = Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways | journal = Oncogene | volume = 21 | issue = 43 | pages = 6633–40 | date = Sep 2002 | pmid = 12242661 | doi = 10.1038/sj.onc.1205850 }}</ref>  and
+* [[P53]].<ref name = pmid12242661/><ref name = pmid11551930>{{cite journal | vauthors = Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W | title = Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 43305–12 | date = Nov 2001 | pmid = 11551930 | doi = 10.1074/jbc.M106050200 }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W | title = Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas | journal = J. Biol. Chem. | volume = 271 | issue = 32 | pages = 19402–8 | year = 1996 | pmid = 8702627 | doi = 10.1074/jbc.271.32.19402 }}
-| citations =
+* {{cite journal | vauthors = Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H | title = Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 | journal = Science | volume = 277 | issue = 5331 | pages = 1501–5 | year = 1997 | pmid = 9278512 | doi = 10.1126/science.277.5331.1501 }}
-*{{cite journal  | author=Li B, Ouyang B, Pan H, ''et al.'' |title=Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. |journal=J. Biol. Chem. |volume=271 |issue= 32 |pages= 19402-8 |year= 1996 |pmid= 8702627 |doi=  }}
+* {{cite journal | vauthors = Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W | title = Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions | journal = J. Biol. Chem. | volume = 272 | issue = 45 | pages = 28646–51 | year = 1997 | pmid = 9353331 | doi = 10.1074/jbc.272.45.28646 }}
-*{{cite journal  | author=Peng CY, Graves PR, Thoma RS, ''et al.'' |title=Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. |journal=Science |volume=277 |issue= 5331 |pages= 1501-5 |year= 1997 |pmid= 9278512 |doi=  }}
+* {{cite journal | vauthors = Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D | title = The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity | journal = EMBO J. | volume = 18 | issue = 20 | pages = 5528–39 | year = 1999 | pmid = 10523297 | pmc = 1171621 | doi = 10.1093/emboj/18.20.5528 }}
-*{{cite journal  | author=Ouyang B, Pan H, Lu L, ''et al.'' |title=Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28646-51 |year= 1997 |pmid= 9353331 |doi=  }}
+* {{cite journal | vauthors = Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W | title = The physical association and phosphorylation of Cdc25C protein phosphatase by Prk | journal = Oncogene | volume = 18 | issue = 44 | pages = 6029–36 | year = 1999 | pmid = 10557092 | doi = 10.1038/sj.onc.1202983 }}
-*{{cite journal  | author=Kauselmann G, Weiler M, Wulff P, ''et al.'' |title=The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5528-39 |year= 1999 |pmid= 10523297 |doi= 10.1093/emboj/18.20.5528 }}
+* {{cite journal | vauthors = Shieh SY, Ahn J, Tamai K, Taya Y, Prives C | title = The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites | journal = Genes Dev. | volume = 14 | issue = 3 | pages = 289–300 | year = 2000 | pmid = 10673501 | pmc = 316358 | doi =  }}
-*{{cite journal  | author=Ouyang B, Li W, Pan H, ''et al.'' |title=The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. |journal=Oncogene |volume=18 |issue= 44 |pages= 6029-36 |year= 1999 |pmid= 10557092 |doi= 10.1038/sj.onc.1202983 }}
+* {{cite journal | vauthors = Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P | title = PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer | journal = Genes Chromosomes Cancer | volume = 27 | issue = 3 | pages = 332–6 | year = 2000 | pmid = 10679924 | doi = 10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K }}
-*{{cite journal  | author=Shieh SY, Ahn J, Tamai K, ''et al.'' |title=The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. |journal=Genes Dev. |volume=14 |issue= 3 |pages= 289-300 |year= 2000 |pmid= 10673501 |doi=  }}
+* {{cite journal | vauthors = Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ | title = Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 19 | pages = 10389–94 | year = 2000 | pmid = 10973490 | pmc = 27034 | doi = 10.1073/pnas.190030497 }}
-*{{cite journal  | author=Dai W, Li Y, Ouyang B, ''et al.'' |title=PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer. |journal=Genes Chromosomes Cancer |volume=27 |issue= 3 |pages= 332-6 |year= 2000 |pmid= 10679924 |doi=  }}
+* {{cite journal | vauthors = Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K | title = Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages | journal = Oncogene | volume = 19 | issue = 42 | pages = 4832–9 | year = 2000 | pmid = 11039900 | doi = 10.1038/sj.onc.1203845 }}
-*{{cite journal  | author=Matsuoka S, Rotman G, Ogawa A, ''et al.'' |title=Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10389-94 |year= 2000 |pmid= 10973490 |doi= 10.1073/pnas.190030497 }}
+* {{cite journal | vauthors = Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ | title = Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase | journal = Nature | volume = 411 | issue = 6833 | pages = 102–7 | year = 2001 | pmid = 11333986 | doi = 10.1038/35075107 }}
-*{{cite journal  | author=Holtrich U, Wolf G, Yuan J, ''et al.'' |title=Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. |journal=Oncogene |volume=19 |issue= 42 |pages= 4832-9 |year= 2000 |pmid= 11039900 |doi= 10.1038/sj.onc.1203845 }}
+* {{cite journal | vauthors = Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W | title = Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 43305–12 | year = 2001 | pmid = 11551930 | doi = 10.1074/jbc.M106050200 }}
-*{{cite journal  | author=Bulavin DV, Higashimoto Y, Popoff IJ, ''et al.'' |title=Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. |journal=Nature |volume=411 |issue= 6833 |pages= 102-7 |year= 2001 |pmid= 11333986 |doi= 10.1038/35075107 }}
+* {{cite journal | vauthors = Latonen L, Taya Y, Laiho M | title = UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts | journal = Oncogene | volume = 20 | issue = 46 | pages = 6784–93 | year = 2001 | pmid = 11709713 | doi = 10.1038/sj.onc.1204883 }}
-*{{cite journal  | author=Xie S, Wu H, Wang Q, ''et al.'' |title=Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43305-12 |year= 2001 |pmid= 11551930 |doi= 10.1074/jbc.M106050200 }}
+* {{cite journal | vauthors = Ahn JY, Li X, Davis HL, Canman CE | title = Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19389–95 | year = 2002 | pmid = 11901158 | doi = 10.1074/jbc.M200822200 }}
-*{{cite journal  | author=Latonen L, Taya Y, Laiho M |title=UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. |journal=Oncogene |volume=20 |issue= 46 |pages= 6784-93 |year= 2001 |pmid= 11709713 |doi= 10.1038/sj.onc.1204883 }}
+* {{cite journal | vauthors = Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM | title = The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 515–25 | year = 2002 | pmid = 11931760 | doi = 10.1016/S1097-2765(02)00473-2 }}
-*{{cite journal  | author=Ahn JY, Li X, Davis HL, Canman CE |title=Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19389-95 |year= 2002 |pmid= 11901158 |doi= 10.1074/jbc.M200822200 }}
+* {{cite journal | vauthors = Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W | title = Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity | journal = Mol. Cell. Biol. | volume = 22 | issue = 10 | pages = 3450–9 | year = 2002 | pmid = 11971976 | pmc = 133784 | doi = 10.1128/MCB.22.10.3450-3459.2002 }}
-*{{cite journal  | author=Sumara I, Vorlaufer E, Stukenberg PT, ''et al.'' |title=The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 515-25 |year= 2002 |pmid= 11931760 |doi=  }}
+* {{cite journal | vauthors = Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ | title = Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways | journal = Oncogene | volume = 21 | issue = 43 | pages = 6633–40 | year = 2002 | pmid = 12242661 | doi = 10.1038/sj.onc.1205850 }}
-*{{cite journal  | author=Wang Q, Xie S, Chen J, ''et al.'' |title=Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3450-9 |year= 2002 |pmid= 11971976 |doi=  }}
+* {{cite journal | vauthors = Tsvetkov L, Xu X, Li J, Stern DF | title = Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8468–75 | year = 2003 | pmid = 12493754 | doi = 10.1074/jbc.M211202200 }}
-*{{cite journal  | author=Bahassi el M, Conn CW, Myer DL, ''et al.'' |title=Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. |journal=Oncogene |volume=21 |issue= 43 |pages= 6633-40 |year= 2002 |pmid= 12242661 |doi= 10.1038/sj.onc.1205850 }}
+* {{cite journal | vauthors = Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W | title = Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2 | journal = Cell Cycle | volume = 1 | issue = 6 | pages = 424–9 | year = 2003 | pmid = 12548019 | doi = 10.4161/cc.1.6.271 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ | title = Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation | journal = Oncogene | volume = 23 | issue = 15 | pages = 2658–63 | year = 2004 | pmid = 14968113 | doi = 10.1038/sj.onc.1207425 }}
-*{{cite journal  | author=Tsvetkov L, Xu X, Li J, Stern DF |title=Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8468-75 |year= 2003 |pmid= 12493754 |doi= 10.1074/jbc.M211202200 }}
-*{{cite journal  | author=Xie S, Wu H, Wang Q, ''et al.'' |title=Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2. |journal=Cell Cycle |volume=1 |issue= 6 |pages= 424-9 |year= 2003 |pmid= 12548019 |doi=  }}
-*{{cite journal  | author=Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ |title=Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. |journal=Oncogene |volume=23 |issue= 15 |pages= 2658-63 |year= 2004 |pmid= 14968113 |doi= 10.1038/sj.onc.1207425 }}
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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

PLK3: Difference between revisions

Latest revision as of 18:18, 7 September 2017

Contents

Function

Interactions

References

Further reading

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