EIF4G3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 4 gamma 3''' is a [[protein]] that in humans is encoded by the ''EIF4G3'' [[gene]].<ref name="pmid9418880">{{cite journal | vauthors = Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N | title = A novel functional human eukaryotic translation initiation factor 4G | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 334–42  | date = Jan 1998 | pmid = 9418880 | pmc = 121501 | doi =  10.1128/mcb.18.1.334}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8672| accessdate = }}</ref> The gene encodes a protein that functions in [[translation (genetics)|translation]] by aiding the assembly of the [[ribosome]] onto the [[messenger RNA]] template.<ref>{{cite journal | vauthors = Gingras AC, Raught B, Sonenberg N | title = eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation | journal = Annu. Rev. Biochem. | volume = 68 | issue =  | pages = 913–63 | year = 1999 | pmid = 10872469 | doi = 10.1146/annurev.biochem.68.1.913 }}</ref> Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to [[eukaryotic translation initiation factor 4 gamma]], the second [[isoform]] [[EIF4G2]] is not an active translation initiation factor.<ref>{{cite journal | vauthors = Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N | title = A novel functional human eukaryotic translation initiation factor 4G | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 334–42 | year = 1998 | pmid = 9418880 | pmc = 121501 | doi = 10.1128/mcb.18.1.334}}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_EIF4G3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hu3.
| PDB = {{PDB2|1hu3}}
| Name = Eukaryotic translation initiation factor 4 gamma, 3
| HGNCid = 3298
| Symbol = EIF4G3
| AltSymbols =; eIF4GII
| OMIM = 603929
| ECnumber = 
| Homologene = 2789
| MGIid = 1923935
| GeneAtlas_image1 = PBB_GE_EIF4G3_201935_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF4G3_201936_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000339 |text = RNA cap binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}
| Process = {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8672
    | Hs_Ensembl = ENSG00000075151
    | Hs_RefseqProtein = NP_003751
    | Hs_RefseqmRNA = NM_003760
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 21005563
    | Hs_GenLoc_end = 21375930
    | Hs_Uniprot = O43432
    | Mm_EntrezGene = 230861
    | Mm_Ensembl = ENSMUSG00000028760
    | Mm_RefseqmRNA = XM_924437
    | Mm_RefseqProtein = XP_929530
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 137265546
    | Mm_GenLoc_end = 137478564
    | Mm_Uniprot = Q6DI78
  }}
}}
'''Eukaryotic translation initiation factor 4 gamma, 3''', also known as '''EIF4G3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8672| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
EIF4G3 has been shown to [[Protein-protein interaction|interact]] with [[PABPC1]].<ref name=pmid9857202>{{cite journal | vauthors = Imataka H, Gradi A, Sonenberg N | title = A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation | journal = EMBO J. | volume = 17 | issue = 24 | pages = 7480–9 | date = Dec 1998 | pmid = 9857202 | pmc = 1171091 | doi = 10.1093/emboj/17.24.7480 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Gingras AC, Raught B, Sonenberg N |title=eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. |journal=Annu. Rev. Biochem. |volume=68 |issue=  |pages= 913-63 |year= 2000 |pmid= 10872469 |doi= 10.1146/annurev.biochem.68.1.913 }}
* {{cite journal | vauthors = Imataka H, Gradi A, Sonenberg N | title = A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation | journal = EMBO J. | volume = 17 | issue = 24 | pages = 7480–9 | year = 1998 | pmid = 9857202 | pmc = 1171091 | doi = 10.1093/emboj/17.24.7480 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N | title = Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E | journal = EMBO J. | volume = 18 | issue = 1 | pages = 270–9 | year = 1999 | pmid = 9878069 | pmc = 1171121 | doi = 10.1093/emboj/18.1.270 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA | title = Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 1871–80 | year = 1999 | pmid = 10022874 | pmc = 83980 | doi =  }}
*{{cite journal  | author=Gradi A, Imataka H, Svitkin YV, ''et al.'' |title=A novel functional human eukaryotic translation initiation factor 4G. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 334-42 |year= 1998 |pmid= 9418880 |doi=  }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 7 | pages = 3491–6 | year = 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=Imataka H, Gradi A, Sonenberg N |title=A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7480-9 |year= 1999 |pmid= 9857202 |doi= 10.1093/emboj/17.24.7480 }}
* {{cite journal | vauthors = Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK | title = A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery | journal = Mol. Cell | volume = 7 | issue = 1 | pages = 193–203 | year = 2001 | pmid = 11172724 | doi = 10.1016/S1097-2765(01)00167-8 }}
*{{cite journal | author=Pyronnet S, Imataka H, Gingras AC, ''et al.'' |title=Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. |journal=EMBO J. |volume=18 |issue= 1 |pages= 270-9 |year= 1999 |pmid= 9878069 |doi= 10.1093/emboj/18.1.270 }}
* {{cite journal | vauthors = Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T, Sonenberg N | title = Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different | journal = J. Virol. | volume = 77 | issue = 8 | pages = 5026–9 | year = 2003 | pmid = 12663812 | pmc = 152112 | doi = 10.1128/JVI.77.8.5026-5029.2003 }}
*{{cite journal | author=Waskiewicz AJ, Johnson JC, Penn B, ''et al.'' |title=Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1871-80 |year= 1999 |pmid= 10022874 |doi=  }}
* {{cite journal | vauthors = Miura T, Shiratori Y, Shimma N | title = Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII | journal = J. Biomol. NMR | volume = 27 | issue = 3 | pages = 279–80 | year = 2003 | pmid = 12975586 | doi = 10.1023/A:1025442322316 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
* {{cite journal | vauthors = Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM | title = Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I | journal = J. Biol. Chem. | volume = 278 | issue = 49 | pages = 48570–9 | year = 2003 | pmid = 14507913 | doi = 10.1074/jbc.M308781200 }}
*{{cite journal | author=Marcotrigiano J, Lomakin IB, Sonenberg N, ''et al.'' |title=A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. |journal=Mol. Cell |volume=7 |issue= 1 |pages= 193-203 |year= 2001 |pmid= 11172724 |doi= }}
* {{cite journal | vauthors = Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T, Belsham GJ | title = Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro | journal = J. Virol. | volume = 78 | issue = 7 | pages = 3271–8 | year = 2004 | pmid = 15016848 | pmc = 371048 | doi = 10.1128/JVI.78.7.3271-3278.2004 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lejeune F, Ranganathan AC, Maquat LE | title = eIF4G is required for the pioneer round of translation in mammalian cells | journal = Nat. Struct. Mol. Biol. | volume = 11 | issue = 10 | pages = 992–1000 | year = 2004 | pmid = 15361857 | doi = 10.1038/nsmb824 }}
*{{cite journal | author=Gradi A, Svitkin YV, Sommergruber W, ''et al.'' |title=Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. |journal=J. Virol. |volume=77 |issue= 8 |pages= 5026-9 |year= 2003 |pmid= 12663812 |doi= }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Miura T, Shiratori Y, Shimma N |title=Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII. |journal=J. Biomol. NMR |volume=27 |issue= 3 |pages= 279-80 |year= 2004 |pmid= 12975586 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Qin H, Raught B, Sonenberg N, ''et al.'' |title=Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 48570-9 |year= 2004 |pmid= 14507913 |doi= 10.1074/jbc.M308781200 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gradi A, Foeger N, Strong R, ''et al.'' |title=Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. |journal=J. Virol. |volume=78 |issue= 7 |pages= 3271-8 |year= 2004 |pmid= 15016848 |doi= }}
*{{cite journal | author=Lejeune F, Ranganathan AC, Maquat LE |title=eIF4G is required for the pioneer round of translation in mammalian cells. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 992-1000 |year= 2004 |pmid= 15361857 |doi= 10.1038/nsmb824 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8672}}
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{{gene-1-stub}}

Latest revision as of 15:58, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.[1][2] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.[3] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.[4]

Interactions

EIF4G3 has been shown to interact with PABPC1.[5]

References

  1. ↑ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  2. ↑ "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".
  3. ↑ Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
  4. ↑ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  5. ↑ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.

Further reading


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