CDC42BPA: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Revision as of 09:26, 30 August 2017

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.^[1]

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

External links

Human CDC42BPA genome location and CDC42BPA gene details page in the UCSC Genome Browser.

Zhao Y, Loyer P, Li H, et al. (1997). "Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases". J. Biol. Chem. 272 (15): 10013–20. doi:10.1074/jbc.272.15.10013. PMID 9092543.
Leung T, Chen XQ, Tan I, et al. (1998). "Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization". Mol. Cell. Biol. 18 (1): 130–40. doi:10.1128/mcb.18.1.130. PMC 121465. PMID 9418861.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Moncrieff CL, Bailey ME, Morrison N, Johnson KJ (1999). "Cloning and chromosomal localization of human Cdc42-binding protein kinase beta". Genomics. 57 (2): 297–300. doi:10.1006/geno.1999.5769. PMID 10198171.
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936.
Ohashi K, Nagata K, Maekawa M, et al. (2000). "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop". J. Biol. Chem. 275 (5): 3577–82. doi:10.1074/jbc.275.5.3577. PMID 10652353.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Nakamura N, Oshiro N, Fukata Y, et al. (2000). "Phosphorylation of ERM proteins at filopodia induced by Cdc42". Genes Cells. 5 (7): 571–81. doi:10.1046/j.1365-2443.2000.00348.x. PMID 10947843.
Lam LT, Pham YC, Nguyen TM, Morris GE (2000). "Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart". Hum. Mol. Genet. 9 (14): 2167–73. doi:10.1093/hmg/9.14.2167. PMID 10958655.
Tan I, Seow KT, Lim L, Leung T (2001). "Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha". Mol. Cell. Biol. 21 (8): 2767–78. doi:10.1128/MCB.21.8.2767-2778.2001. PMC 86907. PMID 11283256.
Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065.
Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
Dong JM, Leung T, Manser E, Lim L (2003). "Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation". Eur. J. Cell Biol. 81 (4): 231–42. doi:10.1078/0171-9335-00238. PMID 12018391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tan I, Cheong A, Lim L, Leung T (2003). "Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity". Gene. 304: 107–15. doi:10.1016/S0378-1119(02)01185-X. PMID 12568720.
Wilkinson S, Paterson HF, Marshall CJ (2005). "Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion". Nat. Cell Biol. 7 (3): 255–61. doi:10.1038/ncb1230. PMID 15723050.
Cmejla R, Petrak J, Cmejlova J (2006). "A novel iron responsive element in the 3'UTR of human MRCKalpha". Biochem. Biophys. Res. Commun. 341 (1): 158–66. doi:10.1016/j.bbrc.2005.12.155. PMID 16412980.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lefort K, Mandinova A, Ostano P, et al. (2007). "Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases". Genes Dev. 21 (5): 562–77. doi:10.1101/gad.1484707. PMC 1820898. PMID 17344417.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

[1]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Serine/threonine-protein kinase MRCK alpha''' is an [[enzyme]] that in humans is encoded by the ''CDC42BPA'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8476| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = CDC42 binding protein kinase alpha (DMPK-like)
- | HGNCid = 1737
- | Symbol = CDC42BPA
- | AltSymbols =; DKFZp686L1738; DKFZp686P1738; FLJ23347; KIAA0451; MRCK; MRCKA; PK428
- | OMIM = 603412
- | ECnumber =
- | Homologene = 55765
- | MGIid = 2441841
- | GeneAtlas_image1 = PBB_GE_CDC42BPA_203794_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CDC42BPA_213595_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_CDC42BPA_214464_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005083 |text = small GTPase regulator activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0031252 |text = leading edge}}
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0031532 |text = actin cytoskeleton reorganization}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8476
-    | Hs_Ensembl = ENSG00000143776
-    | Hs_RefseqProtein = NP_003598
-    | Hs_RefseqmRNA = NM_003607
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 225244189
-    | Hs_GenLoc_end = 225572798
-    | Hs_Uniprot = Q5VT25
-    | Mm_EntrezGene = 226751
-    | Mm_Ensembl = ENSMUSG00000026490
-    | Mm_RefseqmRNA = XM_900254
-    | Mm_RefseqProtein = XP_905347
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 181836036
-    | Mm_GenLoc_end = 181998838
-    | Mm_Uniprot =
-  }}
-}}
-'''CDC42 binding protein kinase alpha (DMPK-like)''', also known as '''CDC42BPA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8476| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.<ref name="entrez">{{cite web | title = Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8476| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CDC42BPA}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Zhao Y, Loyer P, Li H, ''et al.'' |title=Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10013-20 |year= 1997 |pmid= 9092543 |doi=  }}
+*{{cite journal  | vauthors=Zhao Y, Loyer P, Li H |title=Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10013–20 |year= 1997 |pmid= 9092543 |doi=10.1074/jbc.272.15.10013  |display-authors=etal}}
-*{{cite journal  | author=Leung T, Chen XQ, Tan I, ''et al.'' |title=Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 130-40 |year= 1998 |pmid= 9418861 |doi=  }}
+*{{cite journal  | vauthors=Leung T, Chen XQ, Tan I |title=Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 130–40 |year= 1998 |pmid= 9418861 |doi=  10.1128/mcb.18.1.130| pmc=121465  |display-authors=etal}}
-*{{cite journal  | author=Seki N, Ohira M, Nagase T, ''et al.'' |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345-9 |year= 1998 |pmid= 9455484 |doi=  }}
+*{{cite journal  | vauthors=Seki N, Ohira M, Nagase T |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=10.1093/dnares/4.5.345  |display-authors=etal}}
-*{{cite journal  | author=Moncrieff CL, Bailey ME, Morrison N, Johnson KJ |title=Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. |journal=Genomics |volume=57 |issue= 2 |pages= 297-300 |year= 1999 |pmid= 10198171 |doi= 10.1006/geno.1999.5769 }}
+*{{cite journal  | vauthors=Moncrieff CL, Bailey ME, Morrison N, Johnson KJ |title=Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. |journal=Genomics |volume=57 |issue= 2 |pages= 297–300 |year= 1999 |pmid= 10198171 |doi= 10.1006/geno.1999.5769 }}
-*{{cite journal  | author=Edwards DC, Sanders LC, Bokoch GM, Gill GN |title=Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. |journal=Nat. Cell Biol. |volume=1 |issue= 5 |pages= 253-9 |year= 1999 |pmid= 10559936 |doi= 10.1038/12963 }}
+*{{cite journal  | vauthors=Edwards DC, Sanders LC, Bokoch GM, Gill GN |title=Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. |journal=Nat. Cell Biol. |volume=1 |issue= 5 |pages= 253–9 |year= 1999 |pmid= 10559936 |doi= 10.1038/12963 }}
-*{{cite journal  | author=Ohashi K, Nagata K, Maekawa M, ''et al.'' |title=Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3577-82 |year= 2000 |pmid= 10652353 |doi=  }}
+*{{cite journal  | vauthors=Ohashi K, Nagata K, Maekawa M |title=Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3577–82 |year= 2000 |pmid= 10652353 |doi=10.1074/jbc.275.5.3577  |display-authors=etal}}
-*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
+*{{cite journal  | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  |display-authors=etal}}
-*{{cite journal  | author=Nakamura N, Oshiro N, Fukata Y, ''et al.'' |title=Phosphorylation of ERM proteins at filopodia induced by Cdc42. |journal=Genes Cells |volume=5 |issue= 7 |pages= 571-81 |year= 2000 |pmid= 10947843 |doi=  }}
+*{{cite journal  | vauthors=Nakamura N, Oshiro N, Fukata Y |title=Phosphorylation of ERM proteins at filopodia induced by Cdc42. |journal=Genes Cells |volume=5 |issue= 7 |pages= 571–81 |year= 2000 |pmid= 10947843 |doi=10.1046/j.1365-2443.2000.00348.x  |display-authors=etal}}
-*{{cite journal  | author=Lam LT, Pham YC, Nguyen TM, Morris GE |title=Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. |journal=Hum. Mol. Genet. |volume=9 |issue= 14 |pages= 2167-73 |year= 2000 |pmid= 10958655 |doi=  }}
+*{{cite journal  | vauthors=Lam LT, Pham YC, Nguyen TM, Morris GE |title=Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. |journal=Hum. Mol. Genet. |volume=9 |issue= 14 |pages= 2167–73 |year= 2000 |pmid= 10958655 |doi=10.1093/hmg/9.14.2167  }}
-*{{cite journal  | author=Tan I, Seow KT, Lim L, Leung T |title=Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=Mol. Cell. Biol. |volume=21 |issue= 8 |pages= 2767-78 |year= 2001 |pmid= 11283256 |doi= 10.1128/MCB.21.8.2767-2778.2001 }}
+*{{cite journal  | vauthors=Tan I, Seow KT, Lim L, Leung T |title=Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=Mol. Cell. Biol. |volume=21 |issue= 8 |pages= 2767–78 |year= 2001 |pmid= 11283256 |doi= 10.1128/MCB.21.8.2767-2778.2001  | pmc=86907 }}
-*{{cite journal  | author=Sumi T, Matsumoto K, Shibuya A, Nakamura T |title=Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 23092-6 |year= 2001 |pmid= 11340065 |doi= 10.1074/jbc.C100196200 }}
+*{{cite journal  | vauthors=Sumi T, Matsumoto K, Shibuya A, Nakamura T |title=Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 23092–6 |year= 2001 |pmid= 11340065 |doi= 10.1074/jbc.C100196200 }}
-*{{cite journal  | author=Lemercier C, Brocard MP, Puvion-Dutilleul F, ''et al.'' |title=Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22045-52 |year= 2002 |pmid= 11929873 |doi= 10.1074/jbc.M201736200 }}
+*{{cite journal  | vauthors=Lemercier C, Brocard MP, Puvion-Dutilleul F |title=Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22045–52 |year= 2002 |pmid= 11929873 |doi= 10.1074/jbc.M201736200 |display-authors=etal}}
-*{{cite journal  | author=Dong JM, Leung T, Manser E, Lim L |title=Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation. |journal=Eur. J. Cell Biol. |volume=81 |issue= 4 |pages= 231-42 |year= 2003 |pmid= 12018391 |doi=  }}
+*{{cite journal  | vauthors=Dong JM, Leung T, Manser E, Lim L |title=Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation. |journal=Eur. J. Cell Biol. |volume=81 |issue= 4 |pages= 231–42 |year= 2003 |pmid= 12018391 |doi=10.1078/0171-9335-00238  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Tan I, Cheong A, Lim L, Leung T |title=Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. |journal=Gene |volume=304 |issue=  |pages= 107-15 |year= 2003 |pmid= 12568720 |doi=  }}
+*{{cite journal  | vauthors=Tan I, Cheong A, Lim L, Leung T |title=Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. |journal=Gene |volume=304 |issue=  |pages= 107–15 |year= 2003 |pmid= 12568720 |doi=10.1016/S0378-1119(02)01185-X  }}
-*{{cite journal  | author=Wilkinson S, Paterson HF, Marshall CJ |title=Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. |journal=Nat. Cell Biol. |volume=7 |issue= 3 |pages= 255-61 |year= 2005 |pmid= 15723050 |doi= 10.1038/ncb1230 }}
+*{{cite journal  | vauthors=Wilkinson S, Paterson HF, Marshall CJ |title=Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. |journal=Nat. Cell Biol. |volume=7 |issue= 3 |pages= 255–61 |year= 2005 |pmid= 15723050 |doi= 10.1038/ncb1230 }}
-*{{cite journal  | author=Cmejla R, Petrak J, Cmejlova J |title=A novel iron responsive element in the 3'UTR of human MRCKalpha. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 158-66 |year= 2006 |pmid= 16412980 |doi= 10.1016/j.bbrc.2005.12.155 }}
+*{{cite journal  | vauthors=Cmejla R, Petrak J, Cmejlova J |title=A novel iron responsive element in the 3'UTR of human MRCKalpha. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 158–66 |year= 2006 |pmid= 16412980 |doi= 10.1016/j.bbrc.2005.12.155 }}
-*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
+*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
-*{{cite journal  | author=Lefort K, Mandinova A, Ostano P, ''et al.'' |title=Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. |journal=Genes Dev. |volume=21 |issue= 5 |pages= 562-77 |year= 2007 |pmid= 17344417 |doi= 10.1101/gad.1484707 }}
+*{{cite journal  | vauthors=Lefort K, Mandinova A, Ostano P |title=Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. |journal=Genes Dev. |volume=21 |issue= 5 |pages= 562–77 |year= 2007 |pmid= 17344417 |doi= 10.1101/gad.1484707  | pmc=1820898 |display-authors=etal}}
 }}
 {{refend}}
-{{protein-stub}}
+{{Serine/threonine-specific protein kinases}}
-{{WikiDoc Sources}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-1-stub}}

CDC42BPA: Difference between revisions

Revision as of 09:26, 30 August 2017

References

External links

Further reading

Navigation menu