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''HU-1 redirects here.  For the helicopter, see [[UH-1 Iroquois]].
{{redirect|HU-1|the helicopter|UH-1 Iroquois}}
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{{Infobox_gene}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
'''Ribosomal protein S6 kinase alpha-1''' is an [[enzyme]] that in humans is encoded by the ''RPS6KA1'' [[gene]].<ref name="pmid8141249">{{cite journal | vauthors = Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M | title = Human rsk isoforms: cloning and characterization of tissue-specific expression | journal = The American Journal of Physiology | volume = 266 | issue = 2 Pt 1 | pages = C351-9 | date = Feb 1994 | pmid = 8141249 | pmc = | doi = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 1
| HGNCid = 10430
| Symbol = RPS6KA1
| AltSymbols =; HU-1; MAPKAPK1A; RSK; RSK1; S6K-alpha 1
| OMIM = 601684
| ECnumber = 
| Homologene = 55703
| MGIid = 104558
| GeneAtlas_image1 = PBB_GE_RPS6KA1_203379_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6195
    | Hs_Ensembl = ENSG00000117676
    | Hs_RefseqProtein = NP_001006666
    | Hs_RefseqmRNA = NM_001006665
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 26728836
    | Hs_GenLoc_end = 26774108
    | Hs_Uniprot = Q15418
    | Mm_EntrezGene = 20111
    | Mm_Ensembl = ENSMUSG00000003644
    | Mm_RefseqmRNA = NM_009097
    | Mm_RefseqProtein = NP_033123
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 133119370
    | Mm_GenLoc_end = 133159860
    | Mm_Uniprot = Q3TIM6
  }}
}}
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 1''', also known as '''RPS6KA1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the RSK (ribosomal S6 kinase) family of [[serine/threonine kinases]]. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase ([[MAPK]]) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6195| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6195| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
RPS6KA1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[IκBα]],<ref name = pmid9214631>{{cite journal | vauthors = Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A | title = IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase | journal = The EMBO Journal | volume = 16 | issue = 11 | pages = 3133–44 | date = Jun 1997 | pmid = 9214631 | pmc = 1169932 | doi = 10.1093/emboj/16.11.3133 }}</ref>
* [[MAPK1]],<ref name = pmid12832467>{{cite journal | vauthors = Roux PP, Richards SA, Blenis J | title = Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4796–804 | date = Jul 2003 | pmid = 12832467 | pmc = 162206 | doi =  10.1128/mcb.23.14.4796-4804.2003}}</ref><ref name = pmid12594221>{{cite journal | vauthors = Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ | title = Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 14926–35 | date = Apr 2003 | pmid = 12594221 | doi = 10.1074/jbc.M300485200 }}</ref><ref name = pmid9915826>{{cite journal | vauthors = Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW | title = Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 2893–8 | date = Jan 1999 | pmid = 9915826 | doi =  10.1074/jbc.274.5.2893}}</ref>
* [[TOB1]]<ref name = pmid11260258>{{cite journal | vauthors = Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T | title = A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob | journal = Genes to Cells | volume = 6 | issue = 2 | pages = 131–8 | date = Feb 2001 | pmid = 11260258 | doi =  10.1046/j.1365-2443.2001.00406.x}}</ref>
* [[TSC2]],<ref name = pmid15342917>{{cite journal | vauthors = Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J | title = Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 37 | pages = 13489–94 | date = Sep 2004 | pmid = 15342917 | pmc = 518784 | doi = 10.1073/pnas.0405659101 }}</ref><ref name = pmid15757502>{{cite journal | vauthors = Rolfe M, McLeod LE, Pratt PF, Proud CG | title = Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) | journal = The Biochemical Journal | volume = 388 | issue = Pt 3 | pages = 973–84 | date = Jun 2005 | pmid = 15757502 | pmc = 1183479 | doi = 10.1042/BJ20041888 }}</ref> and
* [[YWHAB]].<ref name = pmid12618428>{{cite journal | vauthors = Cavet ME, Lehoux S, Berk BC | title = 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 18376–83 | date = May 2003 | pmid = 12618428 | doi = 10.1074/jbc.M208475200 }}</ref>
{{Div col end}}
 
== See also ==
* [[Ribosomal s6 kinase]]
* [[Ribosomal s6 kinase]]


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{Refbegin | 2}}
| citations =
* {{cite journal | vauthors = Chen RH, Sarnecki C, Blenis J | title = Nuclear localization and regulation of erk- and rsk-encoded protein kinases | journal = Molecular and Cellular Biology | volume = 12 | issue = 3 | pages = 915–27 | date = Mar 1992 | pmid = 1545823 | pmc = 369523 | doi =  10.1128/mcb.12.3.915}}
*{{cite journal | author=Chen RH, Sarnecki C, Blenis J |title=Nuclear localization and regulation of erk- and rsk-encoded protein kinases. |journal=Mol. Cell. Biol. |volume=12 |issue= 3 |pages= 915-27 |year= 1992 |pmid= 1545823 |doi=  }}
* {{cite journal | vauthors = Tratner I, Ofir R, Verma IM | title = Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential | journal = Molecular and Cellular Biology | volume = 12 | issue = 3 | pages = 998–1006 | date = Mar 1992 | pmid = 1545828 | pmc = 369532 | doi =  10.1128/mcb.12.3.998}}
*{{cite journal | author=Tratner I, Ofir R, Verma IM |title=Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential. |journal=Mol. Cell. Biol. |volume=12 |issue= 3 |pages= 998-1006 |year= 1992 |pmid= 1545828 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Chen RH, Abate C, Blenis J | title = Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 23 | pages = 10952–6 | date = Dec 1993 | pmid = 8248197 | pmc = 47899 | doi = 10.1073/pnas.90.23.10952 }}
*{{cite journal | author=Moller DE, Xia CH, Tang W, ''et al.'' |title=Human rsk isoforms: cloning and characterization of tissue-specific expression. |journal=Am. J. Physiol. |volume=266 |issue= 2 Pt 1 |pages= C351-9 |year= 1994 |pmid= 8141249 |doi= }}
* {{cite journal | vauthors = Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME | title = A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity | journal = Molecular and Cellular Biology | volume = 13 | issue = 10 | pages = 6260–73 | date = Oct 1993 | pmid = 8413226 | pmc = 364685 | doi =  10.1128/mcb.13.10.6260}}
*{{cite journal | author=Chen RH, Abate C, Blenis J |title=Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 10952-6 |year= 1994 |pmid= 8248197 |doi=  }}
* {{cite journal | vauthors = Chen ZJ, Parent L, Maniatis T | title = Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity | journal = Cell | volume = 84 | issue = 6 | pages = 853–62 | date = Mar 1996 | pmid = 8601309 | doi = 10.1016/S0092-8674(00)81064-8 }}
*{{cite journal | author=Rivera VM, Miranti CK, Misra RP, ''et al.'' |title=A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6260-73 |year= 1993 |pmid= 8413226 |doi= }}
* {{cite journal | vauthors = Barge RM, de Koning JP, Pouwels K, Dong F, Löwenberg B, Touw IP | title = Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route | journal = Blood | volume = 87 | issue = 6 | pages = 2148–53 | date = Mar 1996 | pmid = 8630373 | doi =  }}
*{{cite journal | author=Chen ZJ, Parent L, Maniatis T |title=Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. |journal=Cell |volume=84 |issue= 6 |pages= 853-62 |year= 1996 |pmid= 8601309 |doi=  }}
* {{cite journal | vauthors = Wong EV, Schaefer AW, Landreth G, Lemmon V | title = Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 18217–23 | date = Jul 1996 | pmid = 8663493 | doi = 10.1074/jbc.271.30.18217 }}
*{{cite journal | author=Barge RM, de Koning JP, Pouwels K, ''et al.'' |title=Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route. |journal=Blood |volume=87 |issue= 6 |pages= 2148-53 |year= 1996 |pmid= 8630373 |doi= }}
* {{cite journal | vauthors = Xing J, Ginty DD, Greenberg ME | title = Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase | journal = Science | volume = 273 | issue = 5277 | pages = 959–63 | date = Aug 1996 | pmid = 8688081 | doi = 10.1126/science.273.5277.959 }}
*{{cite journal | author=Wong EV, Schaefer AW, Landreth G, Lemmon V |title=Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18217-23 |year= 1996 |pmid= 8663493 |doi= }}
* {{cite journal | vauthors = Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR | title = The signal-dependent coactivator CBP is a nuclear target for pp90RSK | journal = Cell | volume = 86 | issue = 3 | pages = 465–74 | date = Aug 1996 | pmid = 8756728 | doi = 10.1016/S0092-8674(00)80119-1 }}
*{{cite journal | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959-63 |year= 1996 |pmid= 8688081 |doi= }}
* {{cite journal | vauthors = Zhao Y, Bjorbaek C, Moller DE | title = Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 29773–9 | date = Nov 1996 | pmid = 8939914 | doi = 10.1074/jbc.271.47.29773 }}
*{{cite journal | author=Nakajima T, Fukamizu A, Takahashi J, ''et al.'' |title=The signal-dependent coactivator CBP is a nuclear target for pp90RSK. |journal=Cell |volume=86 |issue= 3 |pages= 465-74 |year= 1996 |pmid= 8756728 |doi= }}
* {{cite journal | vauthors = Zaheer A, Lim R | title = Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA | journal = The Journal of Biological Chemistry | volume = 272 | issue = 8 | pages = 5183–6 | date = Feb 1997 | pmid = 9030586 | doi = 10.1074/jbc.272.8.5183 }}
*{{cite journal | author=Zhao Y, Bjorbaek C, Moller DE |title=Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. |journal=J. Biol. Chem. |volume=271 |issue= 47 |pages= 29773-9 |year= 1997 |pmid= 8939914 |doi= }}
* {{cite journal | vauthors = Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A | title = IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase | journal = The EMBO Journal | volume = 16 | issue = 11 | pages = 3133–44 | date = Jun 1997 | pmid = 9214631 | pmc = 1169932 | doi = 10.1093/emboj/16.11.3133 }}
*{{cite journal | author=Zaheer A, Lim R |title=Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA. |journal=J. Biol. Chem. |volume=272 |issue= 8 |pages= 5183-6 |year= 1997 |pmid= 9030586 |doi= }}
* {{cite journal | vauthors = Li HL, Forman MS, Kurosaki T, Puré E | title = Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 29 | pages = 18200–8 | date = Jul 1997 | pmid = 9218456 | doi = 10.1074/jbc.272.29.18200 }}
*{{cite journal | author=Schouten GJ, Vertegaal AC, Whiteside ST, ''et al.'' |title=IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3133-44 |year= 1997 |pmid= 9214631 |doi= 10.1093/emboj/16.11.3133 }}
* {{cite journal | vauthors = Chang YW, Traugh JA | title = Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 45 | pages = 28252–7 | date = Nov 1997 | pmid = 9353277 | doi = 10.1074/jbc.272.45.28252 }}
*{{cite journal | author=Li HL, Forman MS, Kurosaki T, Puré E |title=Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells. |journal=J. Biol. Chem. |volume=272 |issue= 29 |pages= 18200-8 |year= 1997 |pmid= 9218456 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Chang YW, Traugh JA |title=Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28252-7 |year= 1997 |pmid= 9353277 |doi= }}
* {{cite journal | vauthors = del Peso L, González-García M, Page C, Herrera R, Nuñez G | title = Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt | journal = Science | volume = 278 | issue = 5338 | pages = 687–9 | date = Oct 1997 | pmid = 9381178 | doi = 10.1126/science.278.5338.687 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P | title = Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1496–505 | date = Jan 1998 | pmid = 9430688 | doi = 10.1074/jbc.273.3.1496 }}
*{{cite journal | author=del Peso L, González-García M, Page C, ''et al.'' |title=Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. |journal=Science |volume=278 |issue= 5338 |pages= 687-9 |year= 1997 |pmid= 9381178 |doi= }}
* {{cite journal | vauthors = Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA | title = pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167 | journal = Molecular and Cellular Biology | volume = 18 | issue = 4 | pages = 1978–84 | date = Apr 1998 | pmid = 9528769 | pmc = 121427 | doi =  10.1128/mcb.18.4.1978}}
*{{cite journal | author=Dalby KN, Morrice N, Caudwell FB, ''et al.'' |title=Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1496-505 |year= 1998 |pmid= 9430688 |doi=  }}
{{Refend}}
*{{cite journal  | author=Joel PB, Smith J, Sturgill TW, ''et al.'' |title=pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 1978-84 |year= 1998 |pmid= 9528769 |doi=  }}
 
}}
{{Serine/threonine-specific protein kinases}}
{{refend}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}


{{protein-stub}}
[[Category:EC 2.7.11]]
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Latest revision as of 09:28, 10 September 2017

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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RefSeq (mRNA)

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Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.[1]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Interactions

RPS6KA1 has been shown to interact with:

See also

References

  1. ↑ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Feb 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology. 266 (2 Pt 1): C351–9. PMID 8141249.
  2. ↑ "Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1".
  3. ↑ Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A (Jun 1997). "IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase". The EMBO Journal. 16 (11): 3133–44. doi:10.1093/emboj/16.11.3133. PMC 1169932. PMID 9214631.
  4. ↑ Roux PP, Richards SA, Blenis J (Jul 2003). "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity". Molecular and Cellular Biology. 23 (14): 4796–804. doi:10.1128/mcb.23.14.4796-4804.2003. PMC 162206. PMID 12832467.
  5. ↑ Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ (Apr 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". The Journal of Biological Chemistry. 278 (17): 14926–35. doi:10.1074/jbc.M300485200. PMID 12594221.
  6. ↑ Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (Jan 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". The Journal of Biological Chemistry. 274 (5): 2893–8. doi:10.1074/jbc.274.5.2893. PMID 9915826.
  7. ↑ Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T (Feb 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131–8. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258.
  8. ↑ Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J (Sep 2004). "Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13489–94. doi:10.1073/pnas.0405659101. PMC 518784. PMID 15342917.
  9. ↑ Rolfe M, McLeod LE, Pratt PF, Proud CG (Jun 2005). "Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)". The Biochemical Journal. 388 (Pt 3): 973–84. doi:10.1042/BJ20041888. PMC 1183479. PMID 15757502.
  10. ↑ Cavet ME, Lehoux S, Berk BC (May 2003). "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity". The Journal of Biological Chemistry. 278 (20): 18376–83. doi:10.1074/jbc.M208475200. PMID 12618428.

Further reading

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