Tropomyosin 3: Difference between revisions

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{{Infobox_gene}}
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'''Tropomyosin alpha-3 chain''' is a [[protein]] that in humans is encoded by the ''TPM3'' [[gene]].<ref name="pmid1829807">{{cite journal |vauthors=Morris CM, Hao QL, Heisterkamp N, Fitzgerald PH, Groffen J | title = Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24 | journal = Oncogene | volume = 6 | issue = 6 | pages = 1093–5 |date=Aug 1991 | pmid = 1829807 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TPM3 tropomyosin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7170| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_TPM3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mv4.
| PDB = {{PDB2|1mv4}}, {{PDB2|2g9j}}, {{PDB2|2tma}}
| Name = Tropomyosin 3
| HGNCid = 12012
| Symbol = TPM3
| AltSymbols =; NEM1; TRK; FLJ41118; MGC14582; MGC3261; MGC72094; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TPMsk3; hscp30
| OMIM = 191030
| ECnumber = 
| Homologene = 77475
| MGIid =
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003779 |text = actin binding}}
  | Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005862 |text = muscle thin filament tropomyosin}}
  | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006937 |text = regulation of muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7170
    | Hs_Ensembl = ENSG00000143549
    | Hs_RefseqProtein = NP_001036816
    | Hs_RefseqmRNA = NM_001043351
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 152395457
    | Hs_GenLoc_end = 152431233
    | Hs_Uniprot = P06753
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Tropomyosin 3''', also known as '''TPM3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TPM3 tropomyosin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7170| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =
| summary_text = This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TPM3 tropomyosin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7170| accessdate = }}</ref>
| summary_text = This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=nem  GeneReviews/NCBI/NIH/UW entry on Nemaline Myopathy]
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Lees-Miller JP, Helfman DM |title=The molecular basis for tropomyosin isoform diversity. |journal=Bioessays |volume=13 |issue= 9 |pages= 429-37 |year= 1992 |pmid= 1796905 |doi= 10.1002/bies.950130902 }}
*{{cite journal  |vauthors=Lees-Miller JP, Helfman DM |title=The molecular basis for tropomyosin isoform diversity. |journal=BioEssays |volume=13 |issue= 9 |pages= 429–37 |year= 1992 |pmid= 1796905 |doi= 10.1002/bies.950130902 }}
*{{cite journal  | author=Pittenger MF, Kazzaz JA, Helfman DM |title=Functional properties of non-muscle tropomyosin isoforms. |journal=Curr. Opin. Cell Biol. |volume=6 |issue= 1 |pages= 96-104 |year= 1994 |pmid= 8167032 |doi=  }}
*{{cite journal  |vauthors=Pittenger MF, Kazzaz JA, Helfman DM |title=Functional properties of non-muscle tropomyosin isoforms. |journal=Curr. Opin. Cell Biol. |volume=6 |issue= 1 |pages= 96–104 |year= 1994 |pmid= 8167032 |doi=10.1016/0955-0674(94)90122-8 }}
*{{cite journal  | author=Gunning P, Weinberger R, Jeffrey P |title=Actin and tropomyosin isoforms in morphogenesis. |journal=Anat. Embryol. |volume=195 |issue= 4 |pages= 311-5 |year= 1997 |pmid= 9108196 |doi=  }}
*{{cite journal  |vauthors=Gunning P, Weinberger R, Jeffrey P |title=Actin and tropomyosin isoforms in morphogenesis. |journal=Anat. Embryol. |volume=195 |issue= 4 |pages= 311–5 |year= 1997 |pmid= 9108196 |doi=10.1007/s004290050050 }}
*{{cite journal  | author=Gunning PW, Schevzov G, Kee AJ, Hardeman EC |title=Tropomyosin isoforms: divining rods for actin cytoskeleton function. |journal=Trends Cell Biol. |volume=15 |issue= 6 |pages= 333-41 |year= 2006 |pmid= 15953552 |doi= 10.1016/j.tcb.2005.04.007 }}
*{{cite journal  |vauthors=Gunning PW, Schevzov G, Kee AJ, Hardeman EC |title=Tropomyosin isoforms: divining rods for actin cytoskeleton function. |journal=Trends Cell Biol. |volume=15 |issue= 6 |pages= 333–41 |year= 2006 |pmid= 15953552 |doi= 10.1016/j.tcb.2005.04.007 }}
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi=  }}
*{{cite journal   |vauthors=Rasmussen HH, van Damme J, Puype M, etal |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 }}
*{{cite journal  | author=Höner B, Shoeman RL, Traub P |title=Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease. |journal=Cell Biol. Int. Rep. |volume=16 |issue= 7 |pages= 603-12 |year= 1992 |pmid= 1516138 |doi= }}
*{{cite journal  |vauthors=Höner B, Shoeman RL, Traub P |title=Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease. |journal=Cell Biol. Int. Rep. |volume=16 |issue= 7 |pages= 603–12 |year= 1992 |pmid= 1516138 |doi=10.1016/S0309-1651(06)80002-0 }}
*{{cite journal  | author=Morris CM, Hao QL, Heisterkamp N, ''et al.'' |title=Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24. |journal=Oncogene |volume=6 |issue= 6 |pages= 1093-5 |year= 1991 |pmid= 1829807 |doi= }}
*{{cite journal  |vauthors=Winder SJ, Walsh MP |title=Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation. |journal=J. Biol. Chem. |volume=265 |issue= 17 |pages= 10148–55 |year= 1990 |pmid= 2161834 |doi=  }}
*{{cite journal  | author=Winder SJ, Walsh MP |title=Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation. |journal=J. Biol. Chem. |volume=265 |issue= 17 |pages= 10148-55 |year= 1990 |pmid= 2161834 |doi=  }}
*{{cite journal  |vauthors=Takahashi K, Hiwada K, Kokubu T |title=Vascular smooth muscle calponin. A novel troponin T-like protein. |journal=Hypertension |volume=11 |issue= 6 Pt 2 |pages= 620–6 |year= 1988 |pmid= 2455687 |doi=  10.1161/01.hyp.11.6.620}}
*{{cite journal  | author=Takahashi K, Hiwada K, Kokubu T |title=Vascular smooth muscle calponin. A novel troponin T-like protein. |journal=Hypertension |volume=11 |issue= 6 Pt 2 |pages= 620-6 |year= 1988 |pmid= 2455687 |doi=  }}
*{{cite journal  |vauthors=Coulier F, Martin-Zanca D, Ernst M, Barbacid M |title=Mechanism of activation of the human trk oncogene. |journal=Mol. Cell. Biol. |volume=9 |issue= 1 |pages= 15–23 |year= 1989 |pmid= 2538716 |doi= | pmc=362140 }}
*{{cite journal  | author=Coulier F, Martin-Zanca D, Ernst M, Barbacid M |title=Mechanism of activation of the human trk oncogene. |journal=Mol. Cell. Biol. |volume=9 |issue= 1 |pages= 15-23 |year= 1989 |pmid= 2538716 |doi=  }}
*{{cite journal  |vauthors=Martin-Zanca D, Hughes SH, Barbacid M |title=A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. |journal=Nature |volume=319 |issue= 6056 |pages= 743–8 |year= 1986 |pmid= 2869410 |doi= 10.1038/319743a0 }}
*{{cite journal  | author=Martin-Zanca D, Hughes SH, Barbacid M |title=A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. |journal=Nature |volume=319 |issue= 6056 |pages= 743-8 |year= 1986 |pmid= 2869410 |doi= 10.1038/319743a0 }}
*{{cite journal  |vauthors=Reinach FC, MacLeod AR |title=Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk oncogene. |journal=Nature |volume=322 |issue= 6080 |pages= 648–50 |year= 1986 |pmid= 3018581 |doi= 10.1038/322648a0 }}
*{{cite journal  | author=Reinach FC, MacLeod AR |title=Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk oncogene. |journal=Nature |volume=322 |issue= 6080 |pages= 648-50 |year= 1986 |pmid= 3018581 |doi= 10.1038/322648a0 }}
*{{cite journal  |vauthors=MacLeod AR, Houlker C, Reinach FC, Talbot K |title=The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin. |journal=Nucleic Acids Res. |volume=14 |issue= 21 |pages= 8413–26 |year= 1987 |pmid= 3024106 |doi=10.1093/nar/14.21.8413  | pmc=311868 }}
*{{cite journal  | author=MacLeod AR, Houlker C, Reinach FC, Talbot K |title=The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin. |journal=Nucleic Acids Res. |volume=14 |issue= 21 |pages= 8413-26 |year= 1987 |pmid= 3024106 |doi=  }}
*{{cite journal  |vauthors=Clayton L, Reinach FC, Chumbley GM, MacLeod AR |title=Organization of the hTMnm gene. Implications for the evolution of muscle and non-muscle tropomyosins. |journal=J. Mol. Biol. |volume=201 |issue= 3 |pages= 507–15 |year= 1988 |pmid= 3418707 |doi=10.1016/0022-2836(88)90633-X }}
*{{cite journal  | author=Clayton L, Reinach FC, Chumbley GM, MacLeod AR |title=Organization of the hTMnm gene. Implications for the evolution of muscle and non-muscle tropomyosins. |journal=J. Mol. Biol. |volume=201 |issue= 3 |pages= 507-15 |year= 1988 |pmid= 3418707 |doi=  }}
*{{cite journal   |vauthors=MacLeod AR, Houlker C, Reinach FC, etal |title=A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 23 |pages= 7835–9 |year= 1986 |pmid= 3865200 |doi=10.1073/pnas.82.23.7835  | pmc=390864 }}
*{{cite journal | author=MacLeod AR, Houlker C, Reinach FC, ''et al.'' |title=A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 23 |pages= 7835-9 |year= 1986 |pmid= 3865200 |doi=  }}
*{{cite journal   |vauthors=Butti MG, Bongarzone I, Ferraresi G, etal |title=A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. |journal=Genomics |volume=28 |issue= 1 |pages= 15–24 |year= 1995 |pmid= 7590742 |doi= 10.1006/geno.1995.1100 }}
*{{cite journal | author=Butti MG, Bongarzone I, Ferraresi G, ''et al.'' |title=A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. |journal=Genomics |volume=28 |issue= 1 |pages= 15-24 |year= 1995 |pmid= 7590742 |doi= 10.1006/geno.1995.1100 }}
*{{cite journal   |vauthors=Laing NG, Wilton SD, Akkari PA, etal |title=A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. |journal=Nat. Genet. |volume=10 |issue= 2 |pages= 249 |year= 1995 |pmid= 7663526 |doi= 10.1038/ng0695-249 }}
*{{cite journal | author=Laing NG, Wilton SD, Akkari PA, ''et al.'' |title=A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. |journal=Nat. Genet. |volume=10 |issue= 2 |pages= 249 |year= 1995 |pmid= 7663526 |doi= 10.1038/ng0695-249 }}
*{{cite journal   |vauthors=Laing NG, Wilton SD, Akkari PA, etal |title=A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. |journal=Nat. Genet. |volume=9 |issue= 1 |pages= 75–9 |year= 1995 |pmid= 7704029 |doi= 10.1038/ng0195-75 }}
*{{cite journal | author=Laing NG, Wilton SD, Akkari PA, ''et al.'' |title=A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. |journal=Nat. Genet. |volume=9 |issue= 1 |pages= 75-9 |year= 1995 |pmid= 7704029 |doi= 10.1038/ng0195-75 }}
*{{cite journal   |vauthors=Wilton SD, Eyre H, Akkari PA, etal |title=Assignment of the human a-tropomyosin gene TPM3 to 1q22→q23 by fluorescence in situ hybridisation. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1–2 |pages= 122–4 |year= 1994 |pmid= 7956350 |doi=10.1159/000133905 }}
*{{cite journal | author=Wilton SD, Eyre H, Akkari PA, ''et al.'' |title=Assignment of the human a-tropomyosin gene TPM3 to 1q22-->q23 by fluorescence in situ hybridisation. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 122-4 |year= 1994 |pmid= 7956350 |doi=  }}
}}
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{{refend}}
{{refend}}
{{PDB Gallery|geneid=7170}}
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{{Cytoskeletal Proteins}}


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Revision as of 06:53, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.[1][2]

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Morris CM, Hao QL, Heisterkamp N, Fitzgerald PH, Groffen J (Aug 1991). "Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24". Oncogene. 6 (6): 1093–5. PMID 1829807.
  2. ↑ 2.0 2.1 "Entrez Gene: TPM3 tropomyosin 3".

External links

Further reading



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