EIF4E2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 4E type 2''' is a [[protein]] that in humans is encoded by the ''EIF4E2'' [[gene]].<ref name="pmid9653160">{{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 14 | pages = 8175–80  | date = Aug 1998 | pmid = 9653160 | pmc = 20949 | doi = 10.1073/pnas.95.14.8175 }}</ref><ref name="pmid9582349">{{cite journal | vauthors = Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N | title = Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein | journal = J. Biol. Chem. | volume = 273 | issue = 21 | pages = 13104–9  | date = Jun 1998 | pmid = 9582349 | pmc =  | doi = 10.1074/jbc.273.21.13104 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9470| accessdate = }}</ref> It belongs to the [[eukaryotic translation initiation factor 4E family]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_EIF4E2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jgb.
| PDB = {{PDB2|2jgb}}, {{PDB2|2jgc}}
| Name = Eukaryotic translation initiation factor 4E family member 2
| HGNCid = 3293
| Symbol = EIF4E2
| AltSymbols =; 4E-LP; 4EHP; EIF4EL3; IF4e
| OMIM = 605895
| ECnumber = 
| Homologene = 31268
| MGIid = 1914440
| GeneAtlas_image1 = PBB_GE_EIF4E2_213571_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF4E2_209393_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000339 |text = RNA cap binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}} {{GNF_GO|id=GO:0006417 |text = regulation of translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9470
    | Hs_Ensembl = ENSG00000135930
    | Hs_RefseqProtein = NP_004837
    | Hs_RefseqmRNA = NM_004846
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 233123601
    | Hs_GenLoc_end = 233156593
    | Hs_Uniprot = O60573
    | Mm_EntrezGene = 26987
    | Mm_Ensembl = ENSMUSG00000026254
    | Mm_RefseqmRNA = NM_001039169
    | Mm_RefseqProtein = NP_001034258
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 89045085
    | Mm_GenLoc_end = 89071659
    | Mm_Uniprot = Q0P688
  }}
}}
'''Eukaryotic translation initiation factor 4E family member 2''', also known as '''EIF4E2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9470| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
EIF4E2 has been shown to [[Protein-protein interaction|interact]] with [[ARIH1]].<ref name=pmid14623119>{{cite journal | vauthors = Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA | title = Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP | journal = FEBS Lett. | volume = 554 | issue = 3 | pages = 501–4  | date = Nov 2003 | pmid = 14623119 | doi = 10.1016/S0014-5793(03)01235-3 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | year = 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
| citations =
* {{cite journal | vauthors = Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA | title = Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP | journal = FEBS Lett. | volume = 554 | issue = 3 | pages = 501–4 | year = 2003 | pmid = 14623119 | doi = 10.1016/S0014-5793(03)01235-3 }}
*{{cite journal | author=Rom E, Kim HC, Gingras AC, ''et al.'' |title=Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13104-9 |year= 1998 |pmid= 9582349 |doi=  }}
* {{cite journal | vauthors = Tee AR, Tee JA, Blenis J | title = Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1 | journal = FEBS Lett. | volume = 564 | issue = 1-2 | pages = 58–62 | year = 2004 | pmid = 15094042 | doi = 10.1016/S0014-5793(04)00313-8 }}
*{{cite journal  | author=Mao M, Fu G, Wu JS, ''et al.'' |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175-80 |year= 1998 |pmid= 9653160 |doi=  }}
* {{cite journal | vauthors = Joshi B, Cameron A, Jagus R | title = Characterization of mammalian eIF4E-family members | journal = Eur. J. Biochem. | volume = 271 | issue = 11 | pages = 2189–203 | year = 2004 | pmid = 15153109 | doi = 10.1111/j.1432-1033.2004.04149.x }}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Okumura F, Zou W, Zhang DE | title = ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP | journal = Genes Dev. | volume = 21 | issue = 3 | pages = 255–60 | year = 2007 | pmid = 17289916 | pmc = 1785121 | doi = 10.1101/gad.1521607 }}
*{{cite journal | author=Tan NG, Ardley HC, Scott GB, ''et al.'' |title=Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. |journal=FEBS Lett. |volume=554 |issue= 3 |pages= 501-4 |year= 2003 |pmid= 14623119 |doi= }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD | title = Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms | journal = J. Mol. Biol. | volume = 368 | issue = 3 | pages = 691–705 | year = 2007 | pmid = 17368478 | doi = 10.1016/j.jmb.2007.02.019 }}
*{{cite journal | author=Tee AR, Tee JA, Blenis J |title=Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. |journal=FEBS Lett. |volume=564 |issue= 1-2 |pages= 58-62 |year= 2004 |pmid= 15094042 |doi= 10.1016/S0014-5793(04)00313-8 }}
* {{cite journal | vauthors = Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E | title = Weak binding affinity of human 4EHP for mRNA cap analogs | journal = RNA | volume = 13 | issue = 5 | pages = 691–7 | year = 2007 | pmid = 17369309 | pmc = 1852817 | doi = 10.1261/rna.453107 }}
*{{cite journal | author=Joshi B, Cameron A, Jagus R |title=Characterization of mammalian eIF4E-family members. |journal=Eur. J. Biochem. |volume=271 |issue= 11 |pages= 2189-203 |year= 2004 |pmid= 15153109 |doi= 10.1111/j.1432-1033.2004.04149.x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Okumura F, Zou W, Zhang DE |title=ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. |journal=Genes Dev. |volume=21 |issue= 3 |pages= 255-60 |year= 2007 |pmid= 17289916 |doi= 10.1101/gad.1521607 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Rosettani P, Knapp S, Vismara MG, ''et al.'' |title=Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. |journal=J. Mol. Biol. |volume=368 |issue= 3 |pages= 691-705 |year= 2007 |pmid= 17368478 |doi= 10.1016/j.jmb.2007.02.019 }}
*{{cite journal | author=Zuberek J, Kubacka D, Jablonowska A, ''et al.'' |title=Weak binding affinity of human 4EHP for mRNA cap analogs. |journal=RNA |volume=13 |issue= 5 |pages= 691-7 |year= 2007 |pmid= 17369309 |doi= 10.1261/rna.453107 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9470}}
{{WikiDoc Sources}}
{{Initiation factors}}
 
 
{{gene-2-stub}}

Latest revision as of 02:31, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.[1][2][3] It belongs to the eukaryotic translation initiation factor 4E family.

Interactions

EIF4E2 has been shown to interact with ARIH1.[4]

References

  1. ↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  2. ↑ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N (Jun 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". J. Biol. Chem. 273 (21): 13104–9. doi:10.1074/jbc.273.21.13104. PMID 9582349.
  3. ↑ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".
  4. ↑ Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (Nov 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119.

Further reading


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