CAMK1: Difference between revisions

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Revision as of 09:10, 30 August 2017

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.^[1]^[2]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.^[2]

References

↑ Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.
↑ ^2.0 ^2.1 "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. PMID 1375933.
Yokokura H, Picciotto MR, Nairn AC, Hidaka H (1995). "The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains". J. Biol. Chem. 270 (40): 23851–9. doi:10.1074/jbc.270.40.23851. PMID 7559563.
Liu F, Thompson MA, Wagner S, et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. 268 (9): 6714–20. PMID 8384217.
Chin D, Winkler KE, Means AR (1998). "Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I". J. Biol. Chem. 272 (50): 31235–40. doi:10.1074/jbc.272.50.31235. PMID 9395448.
Hsu LS, Tsou AP, Chi CW, et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci. 5 (2): 141–9. doi:10.1007/bf02258368. PMID 9662074.
Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase". J. Biol. Chem. 274 (15): 10086–93. doi:10.1074/jbc.274.15.10086. PMID 10187789.
Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
Hosaka M, Hammer RE, Südhof TC (1999). "A phospho-switch controls the dynamic association of synapsins with synaptic vesicles". Neuron. 24 (2): 377–87. doi:10.1016/S0896-6273(00)80851-X. PMID 10571231.
Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature. 408 (6808): 106–11. doi:10.1038/35040593. PMID 11081517.
McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMC 18930. PMID 11114197.
Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
Condon JC, Pezzi V, Drummond BM, et al. (2002). "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase". Endocrinology. 143 (9): 3651–7. doi:10.1210/en.2001-211359. PMID 12193581.
Sakurada K, Kato H, Nagumo H, et al. (2003). "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin". J. Biol. Chem. 277 (47): 45473–9. doi:10.1074/jbc.M206673200. PMID 12237306.
Clapperton JA, Martin SR, Smerdon SJ, et al. (2003). "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism". Biochemistry. 41 (50): 14669–79. doi:10.1021/bi026660t. PMID 12475216.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.

External links

Human CAMK1 genome location and CAMK1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid7641687-1] Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Calcium/calmodulin-dependent protein kinase type 1''' is an [[enzyme]] that in humans is encoded by the ''CAMK1'' [[gene]].<ref name="pmid7641687">{{cite journal | vauthors = Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR | title = Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase | journal = EMBO J | volume = 14 | issue = 15 | pages = 3679–86 |date=Sep 1995 | pmid = 7641687 | pmc = 394442 | doi =  }}</ref><ref name="entrez"/>
-| require_manual_inspection = no
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_CAMK1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a06.
- | PDB = {{PDB2|1a06}}
- | Name = Calcium/calmodulin-dependent protein kinase I
- | HGNCid = 1459
- | Symbol = CAMK1
- | AltSymbols =; CAMKI; MGC120317; MGC120318
- | OMIM = 604998
- | ECnumber =
- | Homologene = 74503
- | MGIid = 1098535
- | GeneAtlas_image1 = PBB_GE_CAMK1_204392_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004685 |text = calmodulin-dependent protein kinase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8536
-    | Hs_Ensembl = ENSG00000134072
-    | Hs_RefseqProtein = NP_003647
-    | Hs_RefseqmRNA = NM_003656
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 9774032
-    | Hs_GenLoc_end = 9786661
-    | Hs_Uniprot = Q14012
-    | Mm_EntrezGene = 52163
-    | Mm_Ensembl = ENSMUSG00000030272
-    | Mm_RefseqmRNA = NM_133926
-    | Mm_RefseqProtein = NP_598687
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 113299901
-    | Mm_GenLoc_end = 113309699
-    | Mm_Uniprot = Q3TDH8
-  }}
-}}
-'''Calcium/calmodulin-dependent protein kinase I''', also known as '''CAMK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536| accessdate = }}</ref>
+| summary_text = Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536| accessdate = }}</ref>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976-81 |year= 1992 |pmid= 1375933 |doi=  }}
+*{{cite journal  | vauthors=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |pmid= 1375933 |doi=  }}
-*{{cite journal  | author=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851-9 |year= 1995 |pmid= 7559563 |doi=  }}
+*{{cite journal  | vauthors=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851–9 |year= 1995 |pmid= 7559563 |doi=10.1074/jbc.270.40.23851  }}
-*{{cite journal  | author=Haribabu B, Hook SS, Selbert MA, ''et al.'' |title=Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. |journal=EMBO J. |volume=14 |issue= 15 |pages= 3679-86 |year= 1995 |pmid= 7641687 |doi=  }}
+*{{cite journal  | vauthors=Liu F, Thompson MA, Wagner S |title=Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6714–20 |year= 1993 |pmid= 8384217 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Liu F, Thompson MA, Wagner S, ''et al.'' |title=Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6714-20 |year= 1993 |pmid= 8384217 |doi=  }}
+*{{cite journal  | vauthors=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235–40 |year= 1998 |pmid= 9395448 |doi=10.1074/jbc.272.50.31235  }}
-*{{cite journal  | author=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235-40 |year= 1998 |pmid= 9395448 |doi=  }}
+*{{cite journal  | vauthors=Hsu LS, Tsou AP, Chi CW |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141–9 |year= 1998 |pmid= 9662074 |doi=  10.1007/bf02258368|display-authors=etal}}
-*{{cite journal  | author=Hsu LS, Tsou AP, Chi CW, ''et al.'' |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141-9 |year= 1998 |pmid= 9662074 |doi=  }}
+*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=10.1074/jbc.273.34.21473  }}
-*{{cite journal  | author=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473-81 |year= 1998 |pmid= 9705275 |doi=  }}
+*{{cite journal  | vauthors=Anderson KA, Means RL, Huang QH |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880–9 |year= 1998 |pmid= 9822657 |doi=10.1074/jbc.273.48.31880  |display-authors=etal}}
-*{{cite journal  | author=Anderson KA, Means RL, Huang QH, ''et al.'' |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880-9 |year= 1998 |pmid= 9822657 |doi=  }}
+*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086–93 |year= 1999 |pmid= 10187789 |doi=10.1074/jbc.274.15.10086  }}
-*{{cite journal  | author=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086-93 |year= 1999 |pmid= 10187789 |doi=  }}
+*{{cite journal  | vauthors=Hayashi Y, Nishio M, Naito Y |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597–602 |year= 1999 |pmid= 10400690 |doi=10.1074/jbc.274.29.20597  |display-authors=etal}}
-*{{cite journal  | author=Hayashi Y, Nishio M, Naito Y, ''et al.'' |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597-602 |year= 1999 |pmid= 10400690 |doi=  }}
+*{{cite journal  | vauthors=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles |journal=Neuron |volume=24 |issue= 2 |pages= 377–87 |year= 1999 |pmid= 10571231 |doi=10.1016/S0896-6273(00)80851-X  }}
-*{{cite journal  | author=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. |journal=Neuron |volume=24 |issue= 2 |pages= 377-87 |year= 1999 |pmid= 10571231 |doi=  }}
+*{{cite journal  | vauthors=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 }}
-*{{cite journal  | author=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139-43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 }}
+*{{cite journal  | vauthors=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593 }}
-*{{cite journal  | author=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. |journal=Nature |volume=408 |issue= 6808 |pages= 106-11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593 }}
+*{{cite journal  | vauthors=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497  | pmc=18930 }}
-*{{cite journal  | author=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400-5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497 }}
+*{{cite journal  | vauthors=Hsu LS, Chen GD, Lee LS |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 |display-authors=etal}}
-*{{cite journal  | author=Hsu LS, Chen GD, Lee LS, ''et al.'' |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113-23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 }}
+*{{cite journal  | vauthors=Condon JC, Pezzi V, Drummond BM |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651–7 |year= 2002 |pmid= 12193581 |doi=10.1210/en.2001-211359  |display-authors=etal}}
-*{{cite journal  | author=Condon JC, Pezzi V, Drummond BM, ''et al.'' |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651-7 |year= 2002 |pmid= 12193581 |doi=  }}
+*{{cite journal  | vauthors=Sakurada K, Kato H, Nagumo H |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473–9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200 |display-authors=etal}}
-*{{cite journal  | author=Sakurada K, Kato H, Nagumo H, ''et al.'' |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473-9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200 }}
+*{{cite journal  | vauthors=Clapperton JA, Martin SR, Smerdon SJ |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669–79 |year= 2003 |pmid= 12475216 |doi=10.1021/bi026660t  |display-authors=etal}}
-*{{cite journal  | author=Clapperton JA, Martin SR, Smerdon SJ, ''et al.'' |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669-79 |year= 2003 |pmid= 12475216 |doi=  }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Izmailova E, Bertley FM, Huang Q |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 |display-authors=etal}}
-*{{cite journal  | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* {{UCSC gene info|CAMK1}}
+{{PDB Gallery|geneid=8536}}
+{{Serine/threonine-specific protein kinases}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:EC 2.7.11]]
+{{gene-3-stub}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

CAMK1: Difference between revisions

Revision as of 09:10, 30 August 2017

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